Abstract
Clinical needs for noninvasive radionuclide methods have often been an important stimulus to further progress in techniques. In disorders such as pulmonary thromboembolism, however, the correct interpretation can only be made with the help of a broad synoptic basis, formed by the treating physician, the X-ray, and the nuclear medicine specialist. This trivial statement has been of topical interest over the past 20 years in the history of ventilation-perfusion (V-P) scanning. Considerable achievements and promising results have undoubtedly been obtained in the examination of aerosol clearance (alveolar permeability and mucociliary transport), regional ventilation, workup for malignancy, identification of inflammation of the parenchyma in the absence of radiological signs, and in noninvasive diagnosis of pulmonary blood flow and volume. Future developments may be very expensive and require highly specialized equipment (PET, cyclotron, etc.), with no assurance that routine clinical application will be available in the near future.
References
Agnew JE, Lopez-Vidriero MT, Pavia D, Clarke SW (1986) Functional small airways defence in symptomless cigarette smokers. Thorax 41:524–530
Agnew JE, Pavia D, Clarke SW (1986) Mucus clearance from peripheral and central airways of asymptomatic cigarette smokers. Bull Eur Physiopathol Respir 22:263–267
Alderson PO, Lee H, Summer WR, Motazedi A, Wagner HN Jr (1979) Comparison of Xe-133 washout and single-breath imaging for the detection of ventilation abnormalities. J Nucl Med 20:917–922
Barron TF, Birnbaum NS, Shane LB (1985) Pneumocystis carinii pneumonia studies by gallium-67 scanning. Radiology 154:791–793
Bisson G, Drapeau G, Lamoureux G, Canton A, Rola-Pleszczynski M, Begin R (1983) Computer-based quantitative analysis of gallium-67 uptake in normal and diseased lungs. Chest 84:513–517
Budinger TF, McNeil BJ, Alderson PO (1982) Perspectives in nuclear medicine: pulmonary studies. J Nucl Med 23:60–65
Coates G, Dolovich M, Köhler D, Newhouse MT (1983) Rapidly changing appearance of deposited submicronic 99m Tc DTPA aerosol in smokers lungs. J Nucl Med 24:P113–114
Corr D, Dolovich M, McCormack D, Obminski G, Newhouse M (1980) The aerochamber: a new demand-inhalation device for delivery of aerosolized drugs. Am Rev Respir Dis 121:123
Davies H, Kitchman R, Gordon I, Helms P (1985) Regional ventilation in infancy. Reversal of adult pattern. N Engl J Med 313:1626–1628
Ewan PW, Jones HA, Rhodes ChG, Hughes JMB (1976) Detection of intrapulmonary hemorrhage with carbon monoxide uptake. N Engl J Med 295:1391–1396
Fischer J, Helbig I, Rühle KH, Matthys H (1979) Mukoziliäre Clearance bei Patienten mit Bronchialkarzinom. Atemwegs Lungenkr 5:267
Hull RD, Hirsh J, Carter CJ, Raskob GE, Gill GJ, Jay RM, Leclerc JR, David M, Coates G (1985) Diagnostic value of ventilation-perfusion lung scanning in patients with suspected pulmonary embolism. Chest 88:819–928
Kipper MS, Moser KM, Kortmann KM, Ashburn WL (1982) Long-term follow-up of patients with suspected pulmonary embolism and a normal lung scan: perfusion scans in embolic suspects. Chest 82:411–415
Köhn H, Klech H, Angelberger P, Strigl A, Zolle I, Kummer F, Mostbeck A (1985) Dry aerosol of monodisperse millimicrospheres for ventilation imaging: production, delivery system, and clinical results in comparison with 81m Krypton and 127 Xenon. Eur J Nucl Med 10:411–416
Kummer F, Havlik E, Ferlitsch A, Lutteroth HW, Höfer R (1978) Seitenspezifische Lungenreaktion auf inhalative Provokationsaerosole. Atemwegs Lungenkr 4:391–393
Lee ME, Biello DR, Kumar B, Siegel BA (1985) “Low-probability” ventilation-perfusion scintigrams: clinical outcomes in 99 patients. Radiology 156:497–500
Lindberg S (1986) Reflex-induced acceleration of mucociliar activity in rabbit after exposure to cigarette smoke. Bull Eur Physiopathol Respir 22:273–279
Marmor AT, Mijiritsky Y, Plich M, Frenkel A, Front D (1986) Improved radionuclide method for assessment of pulmonary artery pressure in COPD. Chest 89:64–69
McNeil BJ (1980) Ventilation-perfusion studies and the diagnosis of pulmonary embolism: concise communication. J Nucl Med 21:319–323
Mason GR, Uzler JM, Effros RM, Reid E (1983) Rapidly reversible alterations of pulmonary epithelial permeability induced by smoking. Chest 83:6–11
MasonGR, DuaneGB, EffrosRM, MenaI (1985) Rapid clearance of inhaled aerosols of technetium-99m DTPA in patients with Pneumocystis carinii pneumonia. J Nucl Med 26:P59
Okada RD, Pohost GM, Kirshenbaum HD, Kushner FG, Boucher CA, Block PC, Strauss W (1979) Radionuclide-determined change in pulmonary blood volume with exercise. N Engl J Med 301:569–576
Orphanidou D, Hughes JMB, Myers JM, Al-Suhali AR, Henderson B (1986) Tomography of regional ventilation and perfusion using krypton 81m in normal subjects and asthmatic patients. Thorax 41:542–551
Remolina C, Khan AU, Santiago TV, Edelmann NH (1981) Positional hypoxemia in unilateral lung disease. N Engl J Med 304:523–525
Riedel M, Stanek V, Widimsky J, Prerovsky I (1982) Longterm follow-up of patients with pulmonary thromboembolism (late prognosis and evolution of hemodynamic and respiratory data). Chest 81:151–158
Rinderknecht J, Shapiro L, Krauthammer M, Taplin G, Wassermann K, Uszler JM, Effros RM (1980) Accelerated clearance of small solutes from the lungs in interstitial lung disease. Am Rev Respir Dis 121:105–117
Rosen JM, Palestro ChJ, Markowitz D, Alderson PO (1986) Significance of single ventilation/perfusion mismatches in krypton-81m/technetium-99m lung scintigraphy. J Nucl Med 27:361–365
Saverymuttu SH, Phillips G, Peters AM, Lavender JP (1985) Indium-111 autologous leucocyte scanning in labor pneumonia and lung abscesses. Thorax 40:925–930
Shih WJ, Simmons G, Lee LY, DeLand FH, Coupal JJ, Domstad PA (1983) Diagnosis of pulmonary edema by In-111 chloride lung-heart imaging. J Nucl Med 24:P70–71
Sovijärvi AA, Pöyhönen L, Kellomäki L, Muittari A (1982) Effects of acute and long-term bronchodilator treatment on regional lung function in asthma assessed with krypton-81m and technetium-99m labeled macroaggregates. Thorax 37:516–520
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Kummer, F. Introduction — clinical aspects. Eur J Nucl Med 13 (Suppl 1), S2–S5 (1987). https://doi.org/10.1007/BF00253283
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DOI: https://doi.org/10.1007/BF00253283