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Local blood flow in Walker 256 metastatic brain tumors

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Abstract

Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-odoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg−1 min−1 and the maximum range in an individual tumor extended over 150 ml hg−1 min−1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg−1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.

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Abbreviations

hg:

hectogram, 100 g.

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Author notes

  1. Ronald G Blasberg

    Present address: Nuclear Medicine Department, Clinical Center, National Institutes of Health, 20205, Bethesda, MD, USA

  2. William R Shapiro & Peter Molnar

    Present address: Department of Pathology, University Medical School of Debrecen, H-4012, POB 23, Debrecen, Hungary

  3. Joseph D Fenstermacher

    Present address: Department of Neurological Surgery, Health Sciences Center, State University of New York, T12-082, 11794, Stony Brook, Stony Brook, NY, USA

Authors and Affiliations

  1. Laboratory of Medicinal Chemistry and Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, NIH, Bldg. 37, Rm. 5A13, 20205, Bethesda, MD, USA

    Ronald G Blasberg, Peter Molnar & Joseph D Fenstermacher

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University, 10021, New York, NY, USA

    William R Shapiro

  3. Theoretical Statistics and Mathematics Branch, National Institute of Mental Health, NIH, 20205, Bethesda, MD, USA

    Clifford S Patlak

Authors
  1. Ronald G Blasberg
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  4. Clifford S Patlak
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  5. Joseph D Fenstermacher
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Blasberg, R.G., Shapiro, W.R., Molnar, P. et al. Local blood flow in Walker 256 metastatic brain tumors. J Neuro-Oncol 2, 195–204 (1984). https://doi.org/10.1007/BF00253271

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