Summary
The plasma GIP response to an oral 50 g glucose tolerance test has been compared in eight non-obese human subjects after 12 and 36 h of fasting. Basal plasma GIP and basal plasma insulin concentrations were similar after 12 and 36 h of fasting. Basal blood glucose was lower after 36 h fasting than after 12 h fasting (P<0.0125). After 36 h fasting the oral glucose tolerance test stimulated higher blood glucose concentrations at 60, 90 and 120 min (p<0.0125) and higher plasma insulin concentrations at similar time points (p<0.05), but stimulated plasma GIP concentrations were similar after 12 and 36 h fasts. These findings show that the increased insulinotrophic effect of oral glucose after 36 h fasting in nonobese subjects is not due to an associated augmentation of the glucose-induced GIP response.
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Andrews, W.J., Henry, R.W., Alam, M.J. et al. Failure of fasting to influence the GIP response to oral glucose in non-obese human subjects. Diabetologia 25, 372–374 (1983). https://doi.org/10.1007/BF00253204
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DOI: https://doi.org/10.1007/BF00253204