Summary
An implantable artificial endocrine pancreas consisting of a coiled single acrylic copolymer capillary surrounded by rat islets (1000/kg body weight) was implanted in 10 streptozotocin-alloxan diabetic dogs. About 5 h following implantation plasma glucose decreased from an initial mean value of 350 mg/dl to 150 mg/dl, and then to 100 mg/dl at 12 h. Plasma insulin increased to a mean of 39 mU/l (range 23–83 mU/l) at 5 h in the recipient animals. In addition a much improved plasma glucose disappearance rate (K = 1.9 ±0.3) with slightly delayed insulin responses was seen after intravenous glucose tolerance tests performed in 4 dogs at 7, 8, 10 and 18 h following implantation. These findings suggest that xenogeneic rat islets implanted as an artificial endocrine pancreas can improve glucose metabolism in the diabetic dog.
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Tze, W.J., Tai, J., Wong, F.C. et al. Studies with implantable artificial capillary units containing rat islets on diabetic dogs. Diabetologia 19, 541–545 (1980). https://doi.org/10.1007/BF00253182
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DOI: https://doi.org/10.1007/BF00253182