References
Ahmann, D. L., Hahn, R. G., Bisel, H. F. et al.: A phase II evaluation of ifosfamide (NSC-109724) treatment of disseminated breast cancer. Proc. Amer. Ass. Cancer Res. 15 (Abstr.), 182 (1974)
Anderson, T., McMenamin, M. G., Schein, P. S.: Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)D-glucopyranose, an antitumor agent with modified bone marrow toxicity. Cancer Res. 35, 761–765 (1975)
Baker, B. R., Ashton, W. T.: Irreversible enzyme inhibitors. 196 active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimetyl-s-triazeno and bearing a terminal phenyl sulfonate group. J. med. Chem. 15, 945–947 (1972)
Bhuyan, B. K., Scheidt, L. G., Fraser, T. J.: Cell cycle phase specificity of antitumor agents. Cancer Res. 32, 398–407 (1972)
Bjornsson, S., Henderson, E. S.: Phase I trial of crystalline antibiotic. Proc. Amer. Ass. Cancer Res. 16 (Abstr.) 268 (1975)
Blokhina, N. G. et al.: Results of treatment of malignant tumors with Ftorafur. Cancer 30, 390–392 (1972)
Bradner, W. T., Hutchison, D. J.: Neocarzinostain (NSC-69856): an antitumor antibiotic effective against leukemia L1210 in mice. Cancer Chemother. Rep. 50, 79–84 (1966)
Brian, P. W., Dawkins, A. W., Grove, J. F. et al.: Phytotoxic compounds produced by Fusarium equiseti. J. exp. Bot. 12, 1–12 (1961)
Bruckner, H. W., Cohen, C. J., Gusberg, S. B. et al.: Chemotherapy of ovarian cancer with adriamycin (ADM) and cisplatinum (DDP) (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 17, 287 (1976)
Cohen, M. H., Mittelman, A.: Initial clinical trials with isofosfamide. Proc. Amer. Ass. Cancer Res. 14 (Abstr.), 64 (1973)
Csanyi, E., Halisz, M.: Cross-resistance studies on 1,6-dibromo-dideoxy-D-mannitol (DBM)-resistant Yoshida s.c. sarcoma. Brit. J. Cancer 21, 353–357 (1967)
Cvitkovic, E., Wittes, R., Golbey, R. et al.: Primary combination chemotherapy (VAB II) for metastatic or unresectable germ cell tumors (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 16, 174 (1975)
Cvitkovic, E., Hayes, D., Golbey, R.: Primary combination chemotherapy (VAB II) for metastatic or unresectable germ cell tumors (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Sco. clin. Oncol. 17, 296 (1976)
Dawkins, A. W., Grove, J. F., Tidd, B. K.: Diacetoxyscirpenol and some related compounds. Chem. Commun. 2, 27 (1965)
Drewinko, B., Gottlieb, J. A.: Action of cis-dichlorodiammine-platinum (II) (NSC-119875) at the cellular level. Cancer Chemother. Rep. 59, 665–673 (1975)
Eagan, R. T., Frytak, S., Rubin, J.: Dianhydrogalactitol (DAG) vs. polychemotherapy in non-small cell lung cancer. Proc. Amr. Ass. Cancer Res. 17, 21 (1976a)
Eagan, R. T., Moertel, C. G., Hahn, R. G., Schutt, A. J.: Phase I study of a five-day intermittent schedule for DAG (NSC-132313). J. nat. Cancer Inst. 56 (1), 179–181 (1976)
Eckhardt, S., Sellei, C., Horvath, I. P., Institoris, L.: Effect of 1,6-dibromo-1,6-dideoxy-D-mannitol on chronic granulocytic leukemia. Cancer Chemother. Rep. 33, 57–61 (1963)
Eckhardt, S., Sellei, C., Institoris, L., Fenyes, G., Karika, S., Hartai, F.: Clinico-pharmacological investigations with myelobromol (DEM), pp. 267–271. III. Congr. Hung. Therap. Invest. Pharmacol., Budapest 1964
Eckhardt, S.: Clinical pharmacology of dibromohexitols. X. International Cancer Congress, Houston 1970
Einhorn, L., Donohue, J.: Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann. Intern. Med. 87, 293–298 (1977)
Flury, E., Mauli, R., Sigg, H. P.: The constitution of diacetoxyseirpenol. Chem. Commun. 2, 26 (1965)
Garibjanian, B., Kline, I., Vadlamudi, S., Golden, A.: Proc. Amer. Ass. Cancer Res. 15, 25 (1974)
Geran, R. I., Congleton, G. F., Dudeck, L. E., Abbott, B. J., Gargus, J. L.: A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. Cancer Chemother. Rep. 4, 53–87 (1974)
Gottlieb, J. A., Freireich, E. J., Bodey, G. P. et al.: Preliminary clinical evaluation of piperazinedione (P), a new crystalline antibiotic. Proc. Amer. Ass. Cancer Res. 16 (Abstr.), 86 (1975)
Griffin, T., Comis, R. L., Lokich, J. et al.: Neocarzinostatin: Phase I study. Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 18, 302 (1977)
Haas, C. D., Stephens, R. L., Hollister, M., Hoogstraten, B.: Phase I evaluation of dianhydrogalactitol (NSC-132313). Cancer treat. Rep. 60 (5) 611–614 (1976)
Haas, C., Goodwin, C., Leite, R. et al.: Phase I study of anguidine. Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 18, 296 (1977)
Hartman, G. et al.: The specific inhibition of the DNA-directed RNA synthesis by rifamycin
Hattori, T. et al.: Clinical experience with FT-207; with special reference to 5-fluorouracil. Jap. J. Cancer Clin. 19, 50–53 (1973)
Hayes, D., Cvitkovic, E., Golbey, R.: Amelioration of renal toxicity of high dose cis-platinum diammine dichloride (CPDD) by mannitol induced diuresis (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 17, 169 (1976)
Heere, L. J., Donnely, S. T.: Antitumor activity of hexamethylmelamine and imidazole carboxamide. Proc. Amer. Ass. Cancer Res. 12 (Abstr.), 101 (1971)
Hidvegi, E. J., Sebestyen, J., Szabo, L. D., Koteles, G. J., Institoris, L.: The effect of dibromodulcitol, diepoxydulcitol and various new cytostatic hexitil derivatives on the metabolic activities of nucleic acid and proteins. II. Biochem. Pharmacol. 25, 1705–1710 (1976)
Hidvegi, E., Lonai, P., Holland, J., Antoni, F., Institoris, L., Horvath, I. P.: The effect of mannitol myeleran and two new abromo hexitole on the metabolic activities of nucleic acids and proteins. I. Biochem. Pharmacol. 16, 2143–2153 (1967)
Higby, D. J., Wallace, H. J., Jr., Holland, J. F.: Cis-diammine-dichloroplatinum (NSC-119875): A phase I study. Cancer Chemother. Rep. 57, 459–463 (1973)
Higby, D. J., Wallace, H. J., Jr., Albert, D. et al.: Diamminodichloroplatinum in the chemotherapy of testicular tumors. J. Urol. 112, 100–104 (1974)
Higby, D. J., Wallace, H. J., Bekesi, J. G.: Reduction of cisdichlorodiammine platinum II (DDP) toxicity by penicillamine (Pn) compounds in animal models and humans (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 16, 131 (1975)
Hill, J. M., Loeb, E., MacLellan, A. et al.: Clinical studies of platinum coordination compounds in the treatment of various malignant diseases. Cancer Chemother. Rep. 59, 647–659 (1975)
Horvath, I. P., Institoris, L.: 11, Part II. Mechanisms of Action 17, 149–155 (1967)
Institoris, L., Horvath, I. P., Csanyi, E.: Influence of the chemical structure on the biological tendency of cytostatic compounds related to dibromonmannitol. I. Structure activity correlations. Arzneimittel-Forsch. 17, 145–149 (1967a)
Institoris, L., Horvath, I. P., Pethes, G., Eckhardt, S.: Mechanisms of action of cytostatic dibromohexitols. Cancer Chemother. Rep. 51, 261–270 (1967b)
Ishida, N., Miyazaki, K., Kumagai, K., Rikimabu, M.: Neocarzinostatin, an antitumor antibiotic of high molecular weight. Isolation, physiochemical properties and biological activities. J. Antibiot. (Tokyo) 18, 68–76 (1965)
Ishida, N., Ishii, K., Kitajima, K., Hiraki, K., Kikuchi, M.: Clinical evaluation of antitumor protein Neocarzinostatin. Proc. of the 8th Internat. Congr. of Chemother., Progr. in Chemother. 3, 927 (1975)
Ishii, K., Nakamura, K.: Cooperative studies on the pancreatic cancer by Neocarzinostatin. Cancer and Chemother. (Japan) 1, 433 (1974)
Kaiser, D. W., Thurston, J. T., Dudley, J. R., Schaefer, F. C., Hechenbleikner, L., Holm-Harsen, D.: Cyanuric chloride derivatives. II. Substituted melamines. J. Amer. chem. Soc. 73, 2984–2986 (1951)
Karev, N. I. et al.: Experience with Ftorafur treatment in breast cancer. Neoplasma 19, 347–350 (1972)
Kaufman, J. H., Mittelman, A.: Phase I study of inosine dialdehyde (diglycoaldehyde NSC 118994). Proc. Amer. Ass. Cancer Res. 16 (Abstr.), 51 (1975)
Kellner, B.: 1,6-dibrommo-1,6-dideoxy-dulcitol: A new antitumor agent. Nature (Lond.) 213, 402–403 (1967)
Kitajima, K.: The clinical evaluation of a new antileukemia agent, Neocarzinostatin. Acta Haemat. jap. 37, 767–772 (1974)
Kovach, J. S., Moertel, C. G., Schutt, A. J. et al.: Phase II study of cis-diamminedichloroplatinum (NSC-119875) in advanced carcinoma of the large bowel. Cancer Chemother. Rep. 57, 357–359 (1973)
Kumagai, K., Miyazaki, K.: The effect of carzinostatin on mouse ascitic leukemia SN-36. J. Antibiot. (Tokyo) 16, 55 (1963)
Kamagai, K., Ono, Y., Niskikawa, T., Ishida, N.: Cytological studies on the effect of Neocarzinostatin on HeLa cells. J. Antibiot. (Tokyo) 19, 69–74 (1966)
Kupchan, S. M. et al.: Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J. Amer. chem. Soc. 94, 1354–1356 (1972)
Lippman, A. J., Helson, C., Helson, L. et al.: Clinical trials of cis-diamminedichloroplatinum (NSC-119875). Cancer Chemother. Rep. 57, 191–200 (1973)
Loeb, E., Hill, J. M., MacLellan, A. et al.: Cis-platinum diamminodichloride in the treatment of squamous cell carcinoma and other malignant diseases. Wadley med. Bull. 5, 281–295 (1975)
Mansy, S., Rosenberg, B., Thomson, A. J.: Binding of cis-and trans-dichlorodiammineplatinum (II) to nucleosides. I. Location of the binding sites. J. Amer. chem. Soc. 95, 1633–1640 (1973)
Massaoka, T., Nakamura, H., Hasegawa, Y., Shibata, H., Tatsumi, N. et al.: Treatment of acute leukemia with Neocarzinostatin (NSC). Jap. J. clin. Hematol. 15, 1309–1319 (1974)
Meriren, D. V.: Belousova, A. K.: The mechanism of action of Ftorafur, a new antineoplastic agent. Vopr. Med. Khim. 18 (3), 253–293 (1972)
Merrin, C.: A new method to prevent toxicity with high doses of cis diammine platinum (therapeutic efficacy in previously treated widespread and recurrent testicular tumors) (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 17, 243 (1976)
Mizuno, S. et al.: Inhibition of DNA-dependent RNA polymerase reaction of Escherichia coli by an antimicrobial antibiotic, streptovaricin. Biochim. biophys. Acta (Amst.) 157, 322–332 (1968)
Munchausen, L. L.: The chemical and biological effects of cisdichlorodiammineplatinum (II), an antitumor agent, on DNA. Proc. nat. Acad. Sci. (Wash.) 71, 4519–4522 (1974)
Munchausen, L. L., Rahn, R. O.: Biologic and chemical effects of cis-dichlorodiammineplatinum (II) (NSC-119875) on DNA. Cancer Chemother. Rep. 59, 643–646 (1975)
Nemeth, L., Institoris, L., Somfai, S., Gal, F., Polyi, I., Sugar, J., Csuki, D., Szentirmey, Z., Kellner, B.: Pharmacologic and antitumor effects of 1,2:5,6-dianhydrogalactitol (NSC-132313). Cancer Chemother. Rep., Part I, 56, (5), 593–602 (1972)
Nishikawa, T., Kumagai, K., Kudo, A., Ishida, N.: Cytological study on the effect of Neocarzinostatin on sarcoma 180 in vivo. J. Antibiot. (Tokyo) 18, 223–227 (1965)
Nitschlke, R., Starling, K., Land, V. et al.: Cis-platinum (PDD) in childhood malignancies (abstract). Proc. Amer. Ass. Cancer Res., Proc. Amer. Soc. clin. Oncol. 17, 310 (1976)
Ohtsubo, K., Kaden, P., Mittermayer, C.: Polyribosomal breakdown in mouse fibroblasts (L-Cells) by fusarenon-X, a toxic principle isolated from Fusarium nivale. Biochim. biophys. Acta (Amst.) 287, 520–525 (1972)
Osieka, R., Bruntsch, U., Gailmeier, W. M. et al.: Cis-diaminodichloro-platin (II) in der Behandlung therapieresistenter maligner Hodenteratome. Dtsch. med. Wschr. 101, 191–195 (1976)
Otvos, L.: Stereochemistry of the reactions of biopolymers III alkylation of DNA with dibromodulcitol and analogous sugars. Chem. Abstr. 76, 109327 (g) (1972)
Piel, I. J., Perlia, C. P.: Phase II study of cis-dichlorodiammineplatinum (II) (NSC-119875) in combination with cyclophosphamide (NSC-26271) in the treatment of human malignancies. Cancer Chemother. Rep. 59, 995–999 (1975)
Piel, I. J., Meyer, D., Perlia, C. P. et al.: Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man. Cancer Chemother. Rep. 58, 871–875 (1974)
Plants yield chemicals active against tumors. Chem. Engl. News 58–59 (Feb. 28, 1972)
Pratt, C., Rivera, G., Shanks, E.: Phase I–II evaluation of piperazinedione in children with cancer. Proc. Amer. Ass. Cancer Res. 16 (Abstr.), 82 (1975)
Roberts, J. J., Pascoe, J. M.: Cross-linking of complementary strands of DNA in mammalian cells by antitumor platinum compounds (letter). Nature (Lond.) 235, 282–284 (1972)
Rodriguez, V., Gottlieb, J. A., Burgess, M. A. et al.: Clinical studies of Baker's antifol (BAF). Proc. Amer. Ass. Cancer Res. 16 (Abstr.), 83 (1975)
Rosenberg, B., Van Camp, L., Krigas, T.: Inhibition of cell division in Escherichia coli by electrolysis products a platinum electrode (letter). Nature (Lond.) 205, 698–699 (1965)
Rosenberg, B.: Platinum coordination complexes in cancer chemotherapy. Naturwissenschaften 60, 399–406 (1973)
Sarma, D., Rajalakshmi, S.: Studies on the interaction of Neocarzinostatin with rat liver DNA in vivo and in vitro. Biochem. Pharmacol. 25, 789–792 (1976)
Schein, P. et al.: DNA synthesis by human bone marrow after incubation with BCNU or chlorozotocin (DNCU, NSC-178248). Proc. Amer. Ass. Cancer Res. 16, 122 (1976)
Skeel, R., Rodriguez, V., Freireich, E. J. et al.: Clinical and pharmacological studies of the folate antagonist, triazinate (Baker's antifol, TZT). Proc. Amer. Ass. Cancer Res. 15 (Abstr.), 77 (1974)
Skeel, R., Cashmer, A., Bertino, J.: Pre-clinical trials of a new triazine antifolate, NSC 139105. Proc. Amer. Ass. Cancer Res. 14 (Abstr.), 52 (1973)
Stolinsky, D. C., Bateman, J. R.: Further experience with hexamethylmelamine (NSC-13875) in the treatment of carcinoma of the cervix. Cancer Chemother. Rep. 57, 497–499 (1973)
Stone, P. J., Kelman, A. D., Sinex, F. M.: Specific binding of anti-tumor drug cis-Pt (NH3)2CI2 to DNA rich in guanine and cytosine (letter). Nature (Lond.) 251, 736–737 (1974)
Takahaski, M., Toriyama, K., Maeda, H., Kikuchi, M., Kumagai, K., Ishida, N.: Clinical trials of a new antitumor polypeptide: Neocarzinostatin (NSC). Tohoku J. exp. Med. 98, 273–280 (1969)
Takita, H., Didolkar, M. S.: Effect of hexamethylmelamine (NSC-13875) on small cell carcinoma of the lung (Phase II study). Cancer Chemother. Rep. 58, 371–374 (1974)
Talley, R. W., O'Bryan, R. M., Gutterman, J. U. et al.: Clinical evaluation of toxic effects of cis-diamminedichloroplatinum (NSC-119875) — phase I clinical study. Cancer Chemother. Rep. 57, 465–471 (1973)
Tatsuno, T., Fujimoto, Y., Morita, Y.: Toxicological research on substances from Fusarium nivale III. The structure of nivalenol and its monacetate. Tetrahedron Lett. 2823 (1969)
Tobey, R. A.: A simple, rapid technique for determination of the effects of chemotherapeutic agents on mammalian cellcycle traverse. Cancer Res. 32, 309–316 (1972)
Tobey, R. A., Crissman, H. A.: Unique techniques for cell cycle analysis utilizing mithramycin and flow microfluorometry. Exp. Cell Res. 93, 235–239 (1975)
Tobey, R. A., Oka, M. S., Crissman, H. A.: Differential effects of two chemotherapeutic agents, streptozotocin and chlorozotocin, on the mammalian cell cycle. Europ. J. Cancer 11, 433–441 (1975)
Vaidivieso, M., Bodey, G. P., McKelvey, E. M. et al.: Proc. Amer. Ass. Cancer Res. 16, 86 (1975)
Vaitkevicius, V. K., Baker, L. H., Burolar, T. R. et al.: Chemotherapy og gastrointestinal adenocarcinoma in cancer chemotherapy — Fundamental concepts and recent advances. Year book medical publisher
Wampler, G. L., Mellette, S. J., Kumperminc, M., Regelson, W.: Hexamethylmelamine (NSC-13875) in the treatment of advanced cancer. Cancer Chemother. Rep. 56, 505–514 (1972)
Wasserman, T. H., Comis, R. L., Handlesman, H., Penta, J. S., Slavik, M., Soper, W. T., Carter, S. K.: Tabular analysis of the clinical chemotherapy in solid tumors. Cancer Chemother. Rep. 36, 399–499 (1975)
Wiltshaw, E., Kroner, T.: Phase II study of cis-dichlorodiammineplatinum (II) (NSC-119875) in advanced adenocarcinoma of the ovary. Cancer treat. Rep. 60, 55–60 (1976)
Wittes, R. E., Yagoda, A., Silvay, O. et al.: Chemotherapy of germ cell tumors of the testis. I. Induction of remissions with vinblastine, actinomycin D, and bleomycin. Cancer 37, 637–645 (1976)
Worzalla, J. F., Ramirez, G., Bryan, G. T.: N-demethylation of the antineoplastic agent hexamethylmelamine by rats and man. Cancer Res. 33, 2810–2815 (1973)
Worzalla, J. F., Kaiman, B. D., Johnson, B. M., Ramirez, G., Bryan, G. T.: Metabolism of hexamethylmelamine-ring C in rats and man. Cancer Res. 34, 2669–2674 (1974)
Worzalla, J. F., Kaiman, B. D., Johnson, B. M., Johnson, R. O., Bryan, G. T.: Biotransformations of a series of methylmelamine homologs of hexamethylmelamine. Proc. Amer. Ass. Cancer Res. 15 (Abstr.), 15 (1974)
Yang, S. S.: Rifamycin antibiotics: Inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts. J. nat. Cancer Inst. 49, 7–25 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carter, S.K. New drugs under clinical evaluation in the United States. Cancer Chemother. Pharmacol. 1, 15–24 (1978). https://doi.org/10.1007/BF00253142
Issue Date:
DOI: https://doi.org/10.1007/BF00253142