Summary
A patient with a benign hepatic neoplasm developing after treatment with estrogenic hormones is described. After excision, the neoplastic tissue was analyzed for the presence of cycosol estrogen and progeterone binding proteins. The noeplasm was classified as focal nodular hyperplasia of the liver and was demonstrated to contain high-affinity cytosol estrogen and progesterone hormone receptors. The estrogen0binding affinity of the neoplasm was three times greater than that of normal liver.
Further investigation of cytosol hormone receptors in estrogen associated hepatic neoplasms will be required to define the role of these binding proteins in the possible etiology of certain liver tumors.
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Adlercreutz, H., Tenhunen, R.: Some aspects of the interaction between natural and synthetic female sex hormones and the liver. Amer. J. Med. 49, 630 (1970)
Editorial: Oral contraceptives and liver nodules. Lancet 1976 I, 843
Edmondson, H. A., Henderson, B., Benton, B.: Liver-cell adenomas associated with use of oral contraceptives. New Engl. J. Med. 294, 470 (1976)
Eisenfeld, A. J., Aten, R., Weinberger, M. et al.: Estrogen receptor in the mammalian liver. Science 191, 862 (1975)
Glassberg, A. B., Rosenbaum, E. H.: Oral contraceptives and malignant hepatoma. Lancet 1976 I, 479
Horwitz, K. B., McGuire, W. L., Pearson, O. H. et al.: Predicting response to endocrine therapy in human breast cancer: A hypothesis. Science 189, 726 (1976)
Jensen, E. V., DeSombre, E. R.: Mechanism of action of the female sex hormones. Ann. Rev. Biochem. 41, 203 (1972)
Lippman, M. E., Bolan, G., Huff, K. H.: The effects of glucocorticoids and progesterone on hormone responsive human breast cancer in long term tissue culture. Cancer Res. 36, 4602 (1976)
Lippman, M. E., Huff, K. H.: A demonstration of androgen and estrogen receptors in human breast cancer using a new protamine sulfate assay. Cancer 38, 868 (1976)
Lippman, M. E., Huff, K., Bolan, G.: Progesterone and glucocorticoid interactions with receptors in breast cancer cells in long term cultures. Ann. N.Y. Acad Sci. 286, 101 (1977)
Mays, E. T., Christopherson, W. M., Hahr, M. M. et al.: Hepatic changes in young women ingesting contraceptive steroids. J. Amer. med. Ass. 235, 730 (1976)
McGuire, W. L., Carbone, P. P., Vollmer, E. P.: Estrogen Receptor in Human Breast Cancer. New York: Raven Press 1975
Milgrom, E., Atger, M., Perrot, M. et al.: Progesterone in uterus and plasma. VI. Uterine progesterone receptors during the estrus cycle and implanation in the Guinea pig. Endocrinology 90, 1071 (1972)
O'Sullivan, J. P.: Oral contraceptives and liver tumors. Proc. roy. Soc. Med. 69, 351 (1976)
Scatchard, G.: The attrction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660 (1942)
Sorensen, T. I. A., Baden, H.: Benign hepatocellular tumors. Scand. J. Gastroent. 10, 113 (1975)
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This work was supported in part by contracts NCI # OD 3323863, and NCI # NOLCM 67110
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Macdonald, J.S., Lippman, M.E., Woolley, P.V. et al. Hepatic estrogen and progesterone receptors in an estrogen-associated hepatic neoplasm. Cancer Chemother. Pharmacol. 1, 135–138 (1978). https://doi.org/10.1007/BF00253113
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DOI: https://doi.org/10.1007/BF00253113