Abstract
While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.
Similar content being viewed by others
References
Beierwaltes WH (1985) Horizons in radionuclide therapy: 1985 update. J Nucl Med 26:421–427
Bravo EL, Tarazi RC, Fouad FM, Vidt DG, Gifford RW (1981) Clonidine-suppression test. A useful aid in the diagnosis of pheochromocytoma. N Engl J Med 305:623–626
Cerny JC, Jackson CE, Talpos GB, Yott JB, Lee MW (1982) Pheochromocytoma in multiple endocrine neoplasia type II: an example of the two-hit theory of neoplasia. Surgery 92:849–852
Chong GC, Beahrs OH, Sizemore GW, Woolner LH (1975) Medullary carcinoma of the thyroid gland. Cancer 35:695–704
Endo K, Shiomi K, Kasagi K, Konishi J, Torizuka K, Nakao K, Tanimura H (1984) Imaging of medullary thyroid cancer with 131I-MIBG. Lancet II:233
Gottlieb JA, Hill CS (1974) Chemotherapy of thyroid cancer with adriamycin. Experience with 30 patients. N Engl J Med 290:193–197
hennessy JF, Wells SA Jr, Ontjes DA, Cooper CW (1973) A comparison of pentagastrin injection and calcium infusion as provocative agents for the detection of medullary carcinoma of the thyroid. J Clin Endocrinol Metab 39:487–495
Nakajo M, Shapiro B, Glowniak J, Sisson JC, Beierwaltes WH (1983) Inverse relationship between cardiac accumulation of meta-[131I] iodobenzylguanidine (I-131 MIBG) and circulating catecholamines in suspected pheochromocytoma. J Nucl Med 24:1127–1134
Knudson AG Jr (1971) Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820–823
Sipple JH (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31:163–166
Sisson JC, Frager MS, Valk TW, Gross MD, Swanson DP, Wieland DM, Tobes MC, Beierwaltes WH, Thompson NW (1981) Scintigraphic localization of pheochromocytoma. N Engl J Med 305:12–17
Tischler AS, Dichter MA, Biales B, Greene LA (1977) Neuroendocrine neoplasms and their cells of origin. N Engl J Med 296:919–924
Treuner J, Feine U, Neithammer D, Muller-Schaumburg W, Meinke I, Eibach E, Dopfer R, Klingebiel T, Grumbach S (1984) Scintigraphic imaging of neuroblastoma with [131I] iodobenzylguanidine. Lancet I:333–334
Valk TW, Frager MS, Gross MD, Sisson JC, Wieland DM, Swanson DP, Mangner TJ, Beierwaltes WH (1981) Spectrum of pheochromocytoma in multiple endocrine neoplasia. A scintigraphic portrayal using 131I-metaiodobenzylguanidine. Ann Intern Med 94:762–767
Wolfe HJ, Melvin KEW, Gervi-Skinner SJ, Al Saadi AA, Juliar JF, Jackson CE, Tashjian AH Jr (1973) C-cell hyperplasia preceding medullary thyroid carcinoma. N Engl J Med 289:437–441
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Itoh, H., Sugie, K., Toyooka, S. et al. Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome. Eur J Nucl Med 11, 502–504 (1986). https://doi.org/10.1007/BF00252798
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00252798