Abstract
The functionality of various zinc complexes of amino acid derivatives as a zinc radiopharmaceutical for pancreas PCT imaging was tested using 65Zn, which has a long half-life, and 62Zn, which has a short half-life. Because of the favorable results obtained in previous in vitro panceas section studies, the ability of those Zn complexes to retain their integrity in the presence of blood serum or in living organisms was screened using Sephadex column chromatography and mice biodistribution studies. A relationship between the structure and stability of Zn complexes played a determining role on the in vivo availability of Zn for the pancreas or liver. Among the Zn complexes tested, the tetra-coordinated structure of the Zn-EDDA complex at an equimolar ratio showed proper accumulation in the pancreas, inducing an appropriate pancreas PCT image in the dog with the positron emitter 62Zn-EDDA administered at 1 mg Zn/kg body weight.
Similar content being viewed by others
References
Atkins HL, Yano Y (1979) Pancreas uptake of zinc thioglucose. Int J Nucl Med Biol 6:54–57
Bradshaw RA, Ericsson LH, Walsh KA, Neurath H (1969) The amino acid sequence of bovine carboxypeptidase A. Proc Natl Acad ScI USA 63:1389–1394
Fujibayashi Y, Saji H, Yomoda I, Torizuka K, Yokoyama A. (1986) A new approach for pancreas seeking 62Zn-radiopharmaceutical. I. Eur J Nucl Med (in press)
Gitlitz PH, Sunderman FW, Hohnadel DC (1974) Ion-exchange chromatography of amino acids in sweat collected from healthy subjects during sauna bathing. Clin Chem 20:1305–1312
Greenlaw RH, Strain WH, Callear TE, Dubilier LD, Strin SC (1962) Experimental studies for scintillation scanning of the pancreas. J Nucl Med 3:47–50
Huber AM, Gershoff SN (1973) Effect of zinc deficiency in rats on insulin release from the pancreas. J Nutr 103:1739–1744
Martell AE, Smith RM (1974) In: Critical stability constants. Plenum Press, New York
Meschan I, Quinn JL, Witcofski RL, Hosick TA (1959) The utilization of radioactive zinc and manganese in an effort to visualize the pancreas. Radiology 73:62–70
Risch VR (1978) Radiopharmaceuticals in pancreatic imaging. In: Heindel ND, Burns HD, Honda T, Brady LW (eds) The chemistry of radiopharmaceuticals. Masson, New York, pp 53–73
Senda M, Tamaki N, Yonekura Y, Tanada S, Nishimura K, Murata K, Fujita T, Konishi J, Torizuka K, Tanaka E, Takami K, Ishimatsu K (1984) Performance characteristics of the newly developed whole-body multiple positron computed tomograph. J Nucl Med 25:107
Ueda N, Nakamoto S, Tanaka Y, Hazue M, Fujibayashi Y, Yokoyama A (1983) Production of Zn-62 and development of Zn-62/Cu-62 generator system. J Nucl Med 24:P124
Yano Y, Budinger TF (1977) Cyclotron-produced Zn-62: its possible use in prostate and pancreas scanning as a Zn-62 amino acid chelate. J Nucl Med 18:815–821
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fuijbayashi, Y., Saji, H., Yomoda, I. et al. A new approach toward a pancreas-seeking zinc radiopharmaceutical. Eur J Nucl Med 11, 488–493 (1986). https://doi.org/10.1007/BF00252795
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00252795