Skip to main content
Log in

Modification of fatty acid composition of lipid accumulating yeasts with cyclopropene fatty acid desaturase inhibitors

  • Applied Microbiology
  • Published:
Applied Microbiology and Biotechnology Aims and scope Submit manuscript

Summary

The effect of cyclopropene fatty acids, sterculic and malvalic, on the lipids of yeasts grown under nitrogen limiting, lipid accumulating, conditions was studied. The ratio of stearic to oleic acid showed a dose response effect, with an increase in stearic acid content as the dose of cyclopropene fatty acid increased, and a corresponding reduction in oleic acid. Linoleic and linolenic acids were not affected to the same extent. These effects are shown for the yeasts Candida sp. 107, Trichosporon cutaneum, and Rhodosporidium toruloides.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Christie WW (1970) Cyclopropane and cyclopropene fatty acids. In: Topics in lipid chemistry, vol I. Edited by FD Gunstone. Logos Press, London

    Google Scholar 

  • Ferrante G, Ohno Y, Kates M (1983) Influence of temperature and growth phase on desaturase activity of the mesophilic yeast Candida lipolytica. Can J Biochem Cell Biol 61:171–177

    Google Scholar 

  • James AT, Harris P, Bezard J (1968) The inhibition of unsaturated fatty acid biosynthesis in plants by sterculic acid. Eur J Biochem 3:318–325

    Google Scholar 

  • Johnson AR, Pearson JA, Shenstone FS, Fogerty AC (1967) Inhibition of the desaturation of stearic to oleic acid by cyclopropene fatty acids. Nature 214:1244–1245

    Google Scholar 

  • McKeon TA, Stumpf PK (1982) Purification and characterisation of the stearoyl-acyl carrier protein desaturase and the Acyl-acyl carrier protein thioesterase from maturing seeds of safflower. J Biol Chem 257:12 141–12 147

    Google Scholar 

  • Ratledge C (1982) Microbial oils and fats. An assessment of their commercial potential. Prog Ind Microbiol 16:119–206

    Google Scholar 

  • Raju PK, Reiser R (1967) Inhibition of fatty acyl desaturase by cyclopropene fatty acids. J Biol Chem 242:379–384

    Google Scholar 

  • Reiser R, Parekh CK, Meinke WW (1963) The metabolism of cyclopropene fatty acids. In: Frazer AC (ed) Biological problems of lipids, vol I. Elsevier, New York

    Google Scholar 

  • Schneider EL, Loke SP, Hopkins DT (1968) Gas-liquid chromatographic analysis of cyclopropenoid fatty acids. J Am Oil Chem Soc 45:585–590

    Google Scholar 

  • Shenstone FS, Vickery JR, Johnson AR (1965) Studies on the chemistry and biological effects of cyclopropenoid compounds. J Agric Food Chem 13:410–414

    Google Scholar 

  • Yano I, Nicholls BW, Morris LJ, James AT (1972) The distribution of cyclopropane and cyclopropene fatty acids in higher plants (Malvaceae) Lipids 7:30–34

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moreton, R.S. Modification of fatty acid composition of lipid accumulating yeasts with cyclopropene fatty acid desaturase inhibitors. Appl Microbiol Biotechnol 22, 42–45 (1985). https://doi.org/10.1007/BF00252154

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00252154

Keywords

Navigation