Skip to main content
Log in

‘Variant’ angina: Evidence for small vessel coronary artery spasm?

  • Case Report
  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

A unique case of ‘variant’ angina pectoris has been observed in a patient with normal coronary arteries and typical chest pain appearing spontaneously at rest, and repeatedly provoked by ergonovine maleate (0.1 mg iv) associated with large transmural perfusion defects on 201Tl-imaging (after ergonovine) and a marked increase in T wave voltage despite no demonstrable spasm of a major coronary artery after the same doses of ergonovine. While saline solution could not provoke chest pain and treatment with a beta-blocking agent increased the frequency of ischemic attacks, a calcium antagonist therapy reduced and eventually eliminated the attacks. Thus, this case provides evidence for yet another aspect of a ‘variant’ form of angina pectoris: small vessel coronary artery spasm.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Berman ND, McLaughlin PR, Huckell VF, Mahon WA, Morch JE, Adelmann AG (1976) Prinzmetal's Angina with coronary artery spasm. Angiographic, pharmacologic, metabolic and radionuclide perfusion studies. Am J Med 60:727–732

    Google Scholar 

  2. Braunwald E (1978) Coranary spasm and acute myocardial infarction — new possibility for treatment and prevention. Editorial. N Engl J Med 299:1301–1303

    Google Scholar 

  3. Burkart F (1977) Rehabilitation nach Herzinfarkt. Praxis 66:92–102

    Google Scholar 

  4. Cipriano PR, Guthaeur DF, Orlick AE, Ricci DR, Wexler L, Silverman JF (1979) The effects of ergonovine maleate on coronary arterial size. Circulation 59:82–89

    Google Scholar 

  5. Curry RC, Pepine CJ, Sabom MB, Conti CR (1979) Similarities of exercise-induced and spontaneous attacks of variant angina. Circulation 59:307–312

    Google Scholar 

  6. Curry EC, Pepine CJ, Sabom MB, Feldmann RL, Christie LG, Conti RC (1977) Effects of ergonovine in patients with and without coronary artery disease. Circulation 56:803–809

    Google Scholar 

  7. Gerson MC, Noble RJ, Wann LS, Faris JV, Morris SN (1979) Noninvasive documentation of Prinzmetal's angina. Am J Cardiol 43:329–334

    Google Scholar 

  8. Heupler FA, Proudfit WL, Razavi M, Shirey EK, Greenstreet R, Sheldon WK (1978) Ergonovine maleate provocative test for coronary arterial spasm. Am J Cardiol 41:631–640

    Google Scholar 

  9. Maseri A, Parodi O, Severi S, Pesola A (1976) Transient transmural reduction of myocardial blood flow, demonstrated by thallium-201 scintigraphy, as a cause of variant angina. Circulation 54:280–288

    Google Scholar 

  10. Maseri A, Severi S, de Nes M, L'Abbate A, Chierchia S Morzilli M, Ballestra AM, Parodi O, Biagini A, Distante A (1978) ‘Variant’ agina: one aspect of a continuous spectrum of vasospastic myocardial ischemia. Am J Cardiol 42:1019–1035

    Google Scholar 

  11. McLaughlin PR, Doherty PW, Martin RP, Goris ML, Harrison DC (1977) Myocardial imaging in a patient with reproducible variant angina. Am J Cardiol 39:126–129

    Google Scholar 

  12. Meller J, Pichard A, Dack S (1976) Coronary arterial spasm in Prinzmetal's angina: a proved hypothesis. Am J Cardiol 37:938–940

    Google Scholar 

  13. Nelson C, Nowak B, Childs H, Weinrauch BL, Forwand S (1977) Provocative testing for coronary arterial spasm: rational, risk and clinical illustrations. Am J Cardiol 40:624–629

    Google Scholar 

  14. Oliva RB, Potts DE, Pluss RG (1973) Coronary arterial spasm in Prinzmetal angina: documentation by coronary arteriography. N Engl J Med 288:745–751

    Google Scholar 

  15. Pfisterer M, Burkart F (1975) Test zur Bestimmung der körperlichen Leistungsfähigkeit drei Wochen nach Myokardinfarkt. Z Kardiol 64:1143–1153

    Google Scholar 

  16. Prinzmetal M, Kennamer R, Merliss R, Wada T, Bor N (1959) Angina pectoris. 1. A variant form of angina pectoris. Am J Med 27:375–388

    Google Scholar 

  17. Ricci DR, Orlick AE, Cipriano PR, Guthauer DF, Harrison DC (1979) Altered adrenergic activity in coronary arterial spasm: insight into mechanism based on study of coronary hemodynamics and the electrocardiogram. Am J Cardiol 43:1073–1079

    Google Scholar 

  18. Schroeder JS, Bolen JL, Quint RA, Clark DA, Hayden WG, Higgins CB, Wexler L (1977) Provocation of coronary spasm with ergonovine maleate. Am J Cardiol 40:487–491

    Google Scholar 

  19. Wiener L, Kasparian H, Duca PR, Walinski P, Gottlieb RS, Hauchel F, Brest AN (1976) Spectrum of coronary arterial spasm. Clinical, angiographic and myocardial metabolic experience in 29 cases. Am J Cardiol 38:945–955

    Google Scholar 

  20. Yasue H, Nagao M, Omote S, Takizawa A, Miwa K, Tanaka S (1978) Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and tris-buffer infusion. Circulation 58:56–62

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pfisterer, M., Müller-Brand, J., Cueni, T. et al. ‘Variant’ angina: Evidence for small vessel coronary artery spasm?. Eur J Nucl Med 5, 529–533 (1980). https://doi.org/10.1007/BF00252044

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00252044

Keywords

Navigation