In vitro and in vivo effects of ferric citrate on 67Ga-citrate uptake by DS sarcoma tumors

Abstract

Ferric citrate inhibited in vitro and in vivo uptake of 67Ga-citrate by DS sarcoma cells. In vitro, gallium micked iron and the uptake of both cations was inhibited by transferrin. In vivo, muscle and tumor tissues were the most affected by simultaneous injection of cold ferric citrate. The different behavior of tumor tissue and blood suggests different binding site characteristics in each case.

This is a preview of subscription content, access via your institution.

References

  1. Anghileri LJ, Heidbreder M (1977) On the mechanism of accumulation of 67Ga by tumors. Oncology 34:74–77

    Google Scholar 

  2. Anghileri LJ, Robert J (1981) Radiogallium as a probe for magnesium-binding sites. 3rd International Symposium on Magnesium, Baden-Baden, West Germany, 22–28, August 1981

  3. Harris AW, Sephton RG (1977) Transferrin promotion of 67Ga and 59Fe uptake by cultured mouse myeloma cells. Cancer Res 37:3634–3638

    Google Scholar 

  4. Hegge FN, Mahler DJ, Larsen SM (1977) The incorporation of Ga-67 into ferritin fraction of rabbit hepatocytes in vivo. JNM 18:937–939

    Google Scholar 

  5. Hill JH, Merz T, Wagner HN Jr (1975) Iron-induced enhancement of 67Ga uptake in a model human leukocyte culture system. JNM 16:1183–1185

    Google Scholar 

  6. Hoffer PB, Miller-Catchpole R, Turner D (1979) Demonstration of lactoferrin in tumor tissue from two patients with positive gallium scans. JNM 20:424–427

    Google Scholar 

  7. Larsen SM, Rasey JS, Allen DR (1980) Common pathway for tumor cell uptake of gallium-67 and iron-59 via a transferrin receptor. J Natl Cancer Inst 64:41–53

    Google Scholar 

  8. Robert J, Thouvenot P, Anghileri LJ, Nicolas A (1981) Sc3+ effects on tumor cells uptake of 67Ga. 2nd International Symposium on Radiopharmacology, Chicago, USA, 8–12 September 1981

  9. Samezina K, Sakamura K, Orii H (1981) The role of ferritin in the in vivo localization of gallium-67. Int J Nucl Med Biol 8:94–95

    Google Scholar 

  10. Terner UK, Wong H (1979) 67Ga and 59Fe uptake in human melanoma cells. Int J Nucl Med Biol 6:23–28

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Anghileri, L.J., Thouvenot, P., Brunotte, F. et al. In vitro and in vivo effects of ferric citrate on 67Ga-citrate uptake by DS sarcoma tumors. Eur J Nucl Med 7, 266–268 (1982). https://doi.org/10.1007/BF00251478

Download citation

Keywords

  • Public Health
  • Iron
  • Citrate
  • Sarcoma
  • Tumor Tissue