In vitro and in vivo effects of ferric citrate on 67Ga-citrate uptake by DS sarcoma tumors


Ferric citrate inhibited in vitro and in vivo uptake of 67Ga-citrate by DS sarcoma cells. In vitro, gallium micked iron and the uptake of both cations was inhibited by transferrin. In vivo, muscle and tumor tissues were the most affected by simultaneous injection of cold ferric citrate. The different behavior of tumor tissue and blood suggests different binding site characteristics in each case.

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Anghileri, L.J., Thouvenot, P., Brunotte, F. et al. In vitro and in vivo effects of ferric citrate on 67Ga-citrate uptake by DS sarcoma tumors. Eur J Nucl Med 7, 266–268 (1982).

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  • Public Health
  • Iron
  • Citrate
  • Sarcoma
  • Tumor Tissue