Skip to main content

Advertisement

SpringerLink
Log in

Detection of malignant soft tissue tumors in bone imaging

  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

A total of 2530 consecutive bone scans were examined to evaluate the number and the type of soft tissue neoplasms detected with bone-seeking phosphonates. Sixty-eight primary or secondary soft tissue neoplasms of 63 patients accumulated 99mTc-methylene diphosphonate and 2 accumulated 99mTc-diphosphonate, and one metastasis was seen as a nonactive ‘cold’ focus in the urinary bladder. The localization of tumors was: 19 in the lung, 15 in the liver, 11 in the kidney, 10 in the peritoneal cavity or ascites, 5 in the large bowel, 4 in the vascular or lymphatic system, 3 in the connective tissue or muscles, 2 in the ovary, 1 in the urinary bladder, and 1 in the brain. Our results differ in many respects from those reported in the literature. The causes of the differences are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baker M, Siddiqui AR, Provisor A, Cohen MD (1983) Radiographic and scintigraphic skeletal imaging in patients with neuroblastoma: Concise communication. J Nucl Med 24:467–469

    Google Scholar 

  2. Baumert JE, Lantieri RL, Horning S, McDougall IR (1980) Liver metastases of breast carcinoma detected on 99mTc-methylene diphosphonate bone scan. AJR 134:389–391

    Google Scholar 

  3. Berg GR, Kalisher L, Osmond JO, Pendergrass HP, Potsaid MS (1973) 99mTc-diphosphonate concentration in primary breast carcinoma. Radiology 109:393–394

    Google Scholar 

  4. Birch SJ, Garvie NM, Ackery DM (1980) Splenic accumulation of technetium-99m methyl diphosphonate in non-Hodgkin's lymphoma. Br J Radiol 53:161–163

    Google Scholar 

  5. Brill DR (1981) Radionuclide imaging of nonneoplastic soft tissue disorders. Semin Nucl Med 11:277–288

    Google Scholar 

  6. Cannon JR Jr, Long RF, Berens SV (1978) Metastatic abdominal implants of endometrial carcinoma demonstrated on 99mTc-methylene diphosphonate bone scan. Clin Nucl Med 3:310–311

    Google Scholar 

  7. Chew FS, Hudson TM, Enneking WF (1981) Radionuclide imaging of soft tissue neoplasms. Semin Nucl Med 11:266–277

    Google Scholar 

  8. Clyne CAC, Perry PM, Gibson A, MacLeod MA (1978) 99Tcm-polyphosphate uptake by breast tumours. Br J Surg 65:773–774

    Google Scholar 

  9. Costello P, Gramm HF, Steinberg D (1977) Simultaneous occurrence of functional asplenia and splenic accumulation of diphosphonate in metastatic breast carcinoma. J Nucl Med 18:1237–1238

    Google Scholar 

  10. Debois JM (1981) Uptake of 99mTc-diphosphonate in liver metastasis of an ovarium carcinoma. Eur J Nucl Med 6:273–275

    Google Scholar 

  11. Dibos PE, Wagner HN (1978) Miscellaneous bone scan findings. In: Dibos PE, Wagner HN (eds) Atlas of nuclear medicine, Vol 4: Bone. WB Saunders, Philadelphia, pp 154–166

    Google Scholar 

  12. Edeling C-J (1976) Bone scintigraphy in children. Nuklearmedizin 15:228–232

    Google Scholar 

  13. Edeling C-J (1983) 99mTc-methylene diphosphonate uptake in a primary Wilms' tumor. Eur J Nucl Med 8:30

    Google Scholar 

  14. Garcia AC, Yeh SDJ, Benua RS (1977) Accumulation of bone seeking radionuclides in liver metastasis from colon carcinoma. Clin Nucl Med 2:265–269

    Google Scholar 

  15. Gates GF (1976) Ovarian carcinoma imaged by 99mTc-pyrophosphate: Case report. J Nucl Med 17:29–30

    Google Scholar 

  16. Gordon L, Schabel SI, Holland RD, Cooper JF (1981) 99mTc-methylene diphosphonate accumulation in ascitic fluid due to neoplasm. Radiology 139:699–702

    Google Scholar 

  17. Grames GM, Jansen C, Carlsen EN, Davidson TR (1975) Abnormal bone scan in intracranial lesions. Radiology 115:129–134

    Google Scholar 

  18. Guiberteau MJ, Potsaid MS, McKusick KA (1976) Accumulation of 99mTc-diphosphonate in four patients with hepatic neoplasm: Case reports. J Nucl Med 17:1060–1061

    Google Scholar 

  19. Hardy JG, Anderson GS, Newble GM (1976) Uptake of 99mTc-pyrophosphate by metastatic extragenital seminoma. J Nucl Med 17:1105–1106

    Google Scholar 

  20. Heisel MA, Miller JH, Reid BS, Siegel SE (1983) Radionuclide bone scan in neuroblastoma. Pediatrics 71:206–209

    Google Scholar 

  21. Horne T, Mogle P, Finsterbush A, Gordin M (1983) Increased uptake of 99mTc-MDP in calcified synovial sarcoma. Eur J Nucl Med 8:75–76

    Google Scholar 

  22. Hughes SPF, Benson MKD, Ell PJ, Britton KE (1977) Use of 99mTc-EHDP as scanning agent in detection of metastases from osteosarcoma. ROEFO 126:551–555

    Google Scholar 

  23. Jackman SJ, Maher FT, Hattery RR (1974) Detection of renal cell carcinoma with 99mTc-polyphosphate imaging of bone: Case report. Mayo Clin Proc 49:297–299

    Google Scholar 

  24. Khan O, Ward C, Meller ST, McCready VR, Husband JE (1983) Localisation of bone imaging agent within the liver and lymph nodes in medullary carcinoma of the thyroid. Nucl Med Commun 4:219–227

    Google Scholar 

  25. Kim EE, Domstad PA, Choy YC, Deland FH (1980) Accumulation of Tc-99m phosphonate complexes in metastatic lesions from colon and lung carcinomas. Eur J Nucl Med 5:299–301

    Google Scholar 

  26. Kirby JC, Bartow JH, Dresser TP, Winebright JW (1982) Accumulation of MDP in hepatic metastases from mucinous adenocarcinoma of the colon. Clin Nucl Med 7:25–27

    Google Scholar 

  27. Lentle BC, Burns PE, Dierich H, Jackson FI (1975) Bone scintiscanning in initial assessment of carcinoma of the breast. Surg Gynecol Obstet 141:43–47

    Google Scholar 

  28. Lowenthal IS, Tow DE, Chang Y (1975) Accumulation of 99mTc-pyrophosphate in two squamous cell carcinomas of the lung: Case report. J Nucl Med 16:1021–1024

    Google Scholar 

  29. Magill HL, Strang MS (1981) Paraspinal metastasis of Wilms' tumor visualized on bone imaging. J Nucl Med 22:481–482

    Google Scholar 

  30. Maher FT (1975) Evaluation of renal and urinary tract abnormalities noted on scintiscans: Retrospective study of 1,711 radionuclide skeletal surveys performed in an 18-month period. Mayo Clin Proc 50:370–378

    Google Scholar 

  31. McLaughlin AF (1975) Uptake of Tc-99m bone scanning agent by lungs with metastatic calcification. J Nucl Med 16:322–323

    Google Scholar 

  32. Oren VO, Uszler JM (1978) Liver metastasis of oat cell carcinoma of lung detected on 99mTc-diphosphonate bone scan. Clin Nucl Med 3:355–357

    Google Scholar 

  33. Ozarda AT, Haynie TP, Gutierrez CR (1983) Recurrent renal cell carcinoma following nephrectomy mimicking a normal kidney on bone scan. Eur J Nucl Med 8:148–149

    Google Scholar 

  34. Park CH, Glassman LM, Thompson NL, Mata JS (1973) Reliability of renal imaging obtained incidentally in polyphosphate-99mTc bone scanning. J Nucl Med 14:534–536

    Google Scholar 

  35. Pilbrow WJ (1979) The urinary tract image obtained during 99mTc bone scanning. Clin Radiol 30:71–77

    Google Scholar 

  36. Poulose KP, Reba RC, Eckelman WC, Goodyear M (1975) Extraosseous localization of 99mTc-Sn pyrophosphate. Br J Radiol 48:724–726

    Google Scholar 

  37. Que L, Wiseman J, Hales IB (1980) Small cell carcinoma of the lung: primary site and hepatic metastases both detected on Tc-99m-pyrophosphate bone scan. Clin Nucl Med 5:260–262

    Google Scholar 

  38. Raghavendra BN, McCauley DI, Passalaqua AM, Braunstein P (1977) Bone scanning in metastatic calcification to the lungs. Clin Nucl Med 2:272–273

    Google Scholar 

  39. Richards AG (1974) Metastatic calcification detected through scanning with 99mTc-polyphosphate. J Nucl Med 15:1057–1060

    Google Scholar 

  40. Rosenfield N, Treves S (1974) Osseous and extraosseus uptake of fluorine-18 and technetium-99m polyphosphate in children with neuroblastoma. Radiology 111:127–133

    Google Scholar 

  41. Rosenthall L (1978) 99mTc-methylene diphosphonate concentration in soft tissue malignant fibrous histiocytoma. Clin Nucl Med 3:58–61

    Google Scholar 

  42. Schultz MM, Morales JO, Fishbein PG, Steinberg AJ (1976) Bilateral breast uptake of 99mTc-polyphosphate in a patient with metastatic adenocarcinoma. Radiology 118:377–378

    Google Scholar 

  43. Sham R, Sain A, Silver L, Seery WH, Cole AT (1977) Localization of 99mTc-phosphate compounds in renal tumors. J Nucl Med 18:311–312

    Google Scholar 

  44. Siegel ME, Walker WJ Jr, Campbell JL (1975) Accumulation of 99mTc-diphosphonate in malignant pleural effusions: Detection and verification. J Nucl Med 16:883–885

    Google Scholar 

  45. Smith FW, Gilday DL, Ash JM, Reid RH (1980) Primary neuroblastoma uptake of technetium-99m-methylene diphosphonate. Radiology 137:501–504

    Google Scholar 

  46. Stevens JS, Clark EE (1977) Liver metastasis of colon adenocarcinoma demonstrated on 99mTc-pyrophosphate bone scan. Clin Nucl Med 2:270–272

    Google Scholar 

  47. Teplick JG, Haskin ME, Alavi A (1976) Calcified intraperitoneal metastases from ovarian carcinoma. AJR 127:1003–1006

    Google Scholar 

  48. Tonami N, Maeda T, Aburano T, Miyake H, Hisada K (1981) Marginal accumulation of 99mTc-methylene diphosphonate in liver metastasis, from stomach carcinoma. Eur J Nucl Med 6:43–45

    Google Scholar 

  49. Tu'meh SS, Polak JF, Kaplan WD (1983) Uptake of 99mTc-MDP by pseudomyxoma peritonei: A case report. Eur J Nucl Med 8:364–366

    Google Scholar 

  50. Vieras F, Boyd C (1975) Diagnostic of renal imaging incidental to bone scintigraphy with 99mTc-phosphate compounds. J Nucl Med 16:1109–1114

    Google Scholar 

  51. Wilkinson RH Jr, Gaede JT (1979) Concentration of Tc-99m methylenediphosphonate in hepatic metastases from squamous cell carcinoma. J Nucl Med 20:303–305

    Google Scholar 

  52. Winter PF (1976) Splenic accumulation of 99mTc-diphosphonate. J Nucl Med 17:850

    Google Scholar 

  53. Wynchank S (1982) 99mTc-methylene diphosphonate lung uptake in mixed small and large cell lymphoma. Eur J Nucl Med 7:47–48

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Päijät-Häme Central Hospital, SF-15850, Lahti 85, Finland

    M. Vorne M.D. & T. Saukko

Authors
  1. M. Vorne M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Saukko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vorne, M., Saukko, T. Detection of malignant soft tissue tumors in bone imaging. Eur J Nucl Med 9, 180–184 (1984). https://doi.org/10.1007/BF00251468

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00251468

Keywords

Search

Navigation