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The biological fate of sulphur colloid

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Abstract

The in-vivo behaviour of sulphur colloid has been investigated using colloids labelled with 35S as well as 99mTc. The rates of clearance of 35S and 99mTc from the blood, the rates of accumulation in liver and bone and the distribution of the two radioisotopes in various organs are all markedly different. The results demonstrate that although technetium is rapidly removed from the blood stream and primarily accumulated in the liver the colloid particles themselves are broken down in vivo with the release of sulphur.

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References

  • Caster WO, Poncelet J, Simon AB, Armstrong WD (1956) Tissue weights of the rat. I. Normal values determined by dissection and chemical methods. Proc Soc Exp Biol Med 91: 122–126

    Google Scholar 

  • Chaudhuri TK, Evans TC, Chaudhuri TK (1973) Autoradiographic studies of distribution in the liver of 198Au and 99mTc-sulfur colloids. Radiology 109: 633–637

    Google Scholar 

  • Frier M, Griffiths PA, Ramsey A (1981) The physical and chemical characteristics of sulphur colloids. Eur J Nucl Med 6: 255–260

    Google Scholar 

  • Haney TA, Ascanio I, Gigliotti JA, Gusmano EA, Bruno GA (1971) Physical and biological properties of a 99mTc-sulfur colloid preparation containing disodium edetate. J Nucl Med 12: 64–68

    Google Scholar 

  • Harper PV, Lathrop KA, Richards P (1964) Tc99m as a radiocolloid. J Nucl Med 5: 382

    Google Scholar 

  • Karran SJ, Eagles CJ, Fleming JS, Ackery DM (1979) In vivo measurement of liver perfusion in the normal and partially hepatectomized rat using Tc-99m sulfur colloid. J Nucl Med 20: 26–31

    Google Scholar 

  • Rosenthall L, Kaye M (1976) Observations on the mechanism of of 99mTc-labelled phosphate complex uptake in metabolic bone disease. Semin Nucl Med 6: 59–67

    Google Scholar 

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Authors and Affiliations

  1. Nottingham General Hospital, Nottingham, England

    Malcolm Frier & Alison Ramsey

  2. St. Georges Hospital, Lincoln, England

    Peter Griffiths

Authors
  1. Malcolm Frier
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  2. Peter Griffiths
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  3. Alison Ramsey
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Frier, M., Griffiths, P. & Ramsey, A. The biological fate of sulphur colloid. Eur J Nucl Med 6, 371–374 (1981). https://doi.org/10.1007/BF00251340

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  • DOI: https://doi.org/10.1007/BF00251340

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