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131I rose bengal: Its use in the evaluation of infantile jaundice


One-hundred ten 131I-rose bengal studies (RBI) were performed in infants suspected of having biliary atresia. Fecal RBI excretion of less than 10% was observed in 72 of 73 cases of extrahepatic biliary atresia, but also in 10 of 37 cases of intrahepatic cholestasis of various origins.

One-hundred twenty-two RBI tests were performed in children operated on for extrahepatic biliary atresia and 71 tests were performed between postsurgical weeks 3 and 8, and 51 tests were done later.

Prognostically, early tests show that fecal RBI excretion of more than 15% was observed in 2 of 34 cases who were later completely jaundice-free and in only 1 of 37 cases where no bile flow restoration occurred.

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  1. Becker FB, Hoeffler DF (1964) The radioactive Rose Bengal test. Its value in the diagnosis of extra-hepatic biliary atresia in young infants. Clin Pediatr 3: 714

    Google Scholar 

  2. Brent RL, Geppert LJ (1959) The use of radioactive Rose Bengal in the evaluation of infantile jaundice. Am J Dis Child 98: 720

    Google Scholar 

  3. Brent RL (1962) Persistent jaundice in infancy. J Pediat 61: 111

    Google Scholar 

  4. Desbuquois B, Tron Ph, Alagille D (1968) Etude de l'excretion fécale et urinaire du Rose Bengale marqué par l'iode radioactif au cours des ictères obstructifs du nouveau-né et du nourrisson. Arch Franç, Ped 25: 379–391

    Google Scholar 

  5. Eliot N, Odievre M, Hadchouel M, Hill C, Flamant R (1977) Analyse statistique des données cliniques biologiques et histologiques dans 288 observations de cholestase néonatale. Arch Franç Ped 34: CCXIII-CCXX

    Google Scholar 

  6. Geppert LJ, Brent RL (1957) Radioactive Rose Bengal: an aid in the differential diagnosis of the jaundiced infant. Am J Dis Child 94: 544

    Google Scholar 

  7. Ghadimi H, Sass-Kortsak A (1961) Evaluation of the radioactive Rose Bengal test for the differential diagnosis of obstructive jaundice in infant. N Engl J Med 265: 351

    Google Scholar 

  8. Hayden PW, Rudd Tho G, Christie DL (1979) Rose Bengal Sodium 131 studies in infants with suspected biliary atresia. Am J Dis Child 133: 834–837

    Google Scholar 

  9. Maksoud JG, Fisher Thom A, Kieffer K, Carvalho-Pinto VA (1971) Fecal excretion of Rose Bengal I131 in the diagnosis of obstructive jaundice in infancy with special reference to biliary atresia. Pediatrics 48: 966–969

    Google Scholar 

  10. Marzano E, Turia B (1965) Il comportamento della prova con rosa bengalo radioiodato nella diagnostica di alcune affezioni epatiche dell'età pediatrica: atresia delle vie biliari extraepatiche, colostasi intraepatiche, epatiti. Acta paediat Lat 18: 110

    Google Scholar 

  11. Neurman L (1960) On the distribution and kinetics of injected I131 Rose Bengal. Acta Medica Scandinavia, Suppl 354, Vol 167

  12. Norkyke RA, Blahd WH (1958) The differential diagnosis of biliary tract obstruction with radioactive rose bengal. J Lab Clin Med 51: 565

    Google Scholar 

  13. Poley JR, Alavpovic P, McConathy JW (1973) Diagnosis of extrahepatic biliary obstruction in infants by immunochemical detection of LP-X and modified 131I-Rose Bengal excretion test. J Lab and Clin Med 81: 325–341

    Google Scholar 

  14. Seltzer RA, Kereiakes JE, Saenger EL (1964) Radiation exposure from radioiodine compounds in pediatrics. Radiology 82: 486–490

    Google Scholar 

  15. Sharp HL, Krivit W, Lowman JT (1967) The diagnosis of complete extrahepatic obstruction by Rose Bengal I131 J Pediat 70: 46–53

    Google Scholar 

  16. Thaler MM (1976) Crytogenic liver disease in young infants. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 5, New York, pp 476–493

  17. Thaler MM (1975) Biliary excretory function and excretory patterns in infantile cryptogenic cholestasis. In: Goresky CA, Fisher MM, Jaundice. Plenum, New York, pp 313–324

    Google Scholar 

  18. Zueezer WW, Brown AL (1961) Neonatal jaundice, A review. Am J Dis Child 87: 101

    Google Scholar 

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Correspondence to J. Yvart.

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Yvart, J., Moati, F., Alvarez, F. et al. 131I rose bengal: Its use in the evaluation of infantile jaundice. Eur J Nucl Med 6, 355–359 (1981).

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  • Public Health
  • Nuclear Medicine
  • Cholestasis
  • Biliary Atresia
  • Bile Flow