Abstract
A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo. When injected intravenously into 12 patients with cancer of the thyroid on thyroxine-replacement therapy, 6 of the 12 patients had localization of the labelled antibody in tumour sites. These results were compared to 131I scans done on the same patients 1 month after stopping thyroxine. The biological half-life of the antibody in the blood was influenced by the levels of circulating thyroglobulin.
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Shepherd, P.S., Lazarus, C.R., Mistry, R.D. et al. Detection of thyroid tumour using a monoclonal 123I anti-human thyroglobulin antibody. Eur J Nucl Med 10, 291–295 (1985). https://doi.org/10.1007/BF00251298
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DOI: https://doi.org/10.1007/BF00251298