Summary
Microtubules and 10 nm-filaments appear to be involved in the functions of the retinal pigment epithelium (RPE). The presence of microtubules in the RPE of light-adapted eyes, but not in dark-adapted eyes, suggests that they may be involved primarily in organelle movement. On the other hand, the random and constant presence of 10 nm-filaments within the basal portion of the PE implies a cytoskeletal role for these filaments.
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References
Basinger S, Hoffman R, Matthes M (1976) Photoreceptor shedding is initiated by light in the frog retina. Science 194:1074–1076.
Bernstein MH (1961) Functional architecture of the retinal epithelium. In: Smelser GK (ed) Structure of the Eye. Academic Press, New York, pp 139–150
Burnside B (1976) Possible roles of microtubules and actin filaments in retinal pigmented epithelium. Exp Eye Res 23:257–275
Cohen AI (1963) Vertebrate retinal cells and their organization. Biol Rev 38:427–459
Dowling JE, Gibbons IR (1962) The fine structure of the pigment epithelium in the albino rat. J Cell Biol 14:459–474
Edelman G (1976) Surface modulation in cell recognition and cell growth. Science 192:218–226
Friend DS, Farquhar MG (1967) Functions of coated vesicles during protein absorption in the rat vas deferens. J Cell Biol 35:357–376
Goldman RD, Milsted A, Schloss JA, Starger J, Yerna M-J (1979) Cytoplasmic fibers in mammalian cells: Cytoskeletal and contractile elements. Ann Rev Physiol 41:703–722
Heiniger H-J, Marshall JD (1979) Pinocytosis in L cells: Its dependence on membrane sterol and the cytoskeleton. Biol Int Rep 3:409–420
Hollyfield JG, Besharse JC, Rayborn ME (1976) The effect of light on the quantity of phagosomes in the pigment epithelium. Exp Eye Res 23:623–635
Ishikawa T, Yamada E (1970) The degradation of the photoreceptor outer segment within the pigment epithelial cell of rat retina. J Electron Microsc 19:85–91
Kushida H (1967) A new embedding method employing DER and EPON. J Electron Microsc 16:278–280
Lasansky A, deFisch FW (1965) Studies on the function of the pigment epithelium in relation to ionic movement between retina and choroid. In: Rohen JW (ed) The Structure of the Eye; II Symposium. Schattauer, Stuttgart, pp 139–144
LaVail MM (1976a) Rod outer segment disc shedding in relation to cyclic lighting. Exp Eye Res 23:277–280
LaVail MM (1976b) Rod outer segment disc shedding in rat retina: Relationship to cyclic lighting. Science 194:1071–1074
Malawista SE (1975) Microtubules and the mobilization of lysosomes in phagocytizing human leukocytes. Ann NY Acad Sci 253:738–749
Matsusaka T (1967) The intracytoplasmic channel in pigment epithelial cells of the chick retina. Z Zellforsch 81:100–113
Meyer DB, Hazlett LD, Susan SR (1973) The fine structure of the retina in the Japanese quail (Coturnix coturnix japonica). I. Pigment epithelium and its vascular barrier. Tissue Cell 5:489–500
Moyer FH (1969) Development, structure, and function of the retinal pigmented epithelium. In: Straatsma BR, Hall MO, Allen RA, Crescitelli F (eds) The Retina: Morphology, Function and Clinical Characteristics. Univ Calif Press, Berkeley and Los Angeles, pp 1–30
Murray RL, Dubin MW (1975) The occurrence of actinlike filaments in association with migrating pigment granules in frog retinal pigment epithelium. J Cell Biol 64:705–710
O'Day WT, Young RW (1978) Rhythmic daily shedding of outer segment membranes by visual cells in the goldfish. J Cell Biol 76:593–604
Porter KR, Yamada E (1960) Studies on the endoplasmic reticulum. V. Its form and differentiation in pigment epithelial cells of the frog retina. J Biophys Biochem Cytol 8:181–205
Silverstein SC, Steinman RM, Cohn ZA (1977) Endocytosis. Ann Rev Biochem 46:667–722
Spitznas M, Hogan MJ (1970) Outer segments of photoreceptors and the retinal pigment epithelium. Arch Ophthalmol NY 84:810–819
Takeuchi IK, Takeuchi YK (1979) Intermediate filaments in the retinal pigment epithelial cells of the goldfish. J Electron Microsc 28:134–137
Yamada E (1961) The fine structure of the pigment epithelium in the turtle eye. In: Smelser GK (ed) The structure of the eye. Academic Press, New York, pp 73–84
Young RW (1971) Shedding of discs from rod outer segments in the Rhesus monkey. J Ultrastruct Res 34:190–213
Young RW (1978a) The daily rhythm of shedding and degradation of rod and cone outer segment membranes in the chick retina. Invest Ophthalmol 17:105–117
Young RW (1978b) Visual cells, daily rhythms, and vision research. Vision Res 18:573–578
Young RW, Bok D (1969) Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol 42:392–403
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The authors thank their colleagues Pierre Couillard and Michel Anctil for helpful advice and criticism during the course of this study. Financial support was provided by the C.R.S.N.G. du Canada and the Ministère de l'Education du Québec (F.C.A.C.)
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Klyne, M.A., Ali, M.A. Microtubules and 10 nm-filaments in the retinal pigment epithelium during the diurnal light-dark-cycle. Cell Tissue Res. 214, 397–405 (1981). https://doi.org/10.1007/BF00249220
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DOI: https://doi.org/10.1007/BF00249220