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Role of brain acetylcholine in vasopressin release during osmotic stimulation and hemorrhage

Experimental Brain Research volume 75, pages 47–52 (1989)Cite this article

Summary

There is considerable evidence to suggest that there is a cholinergic link in the neural control of vasopressin release, but the precise role for this link has not been adequately demonstrated in the intact animal. We have, therefore, examined in conscious unrestrained rats the effects of central cholinergic blockade on the stimulation of vasopressin release by increased plasma osmotality (iv infusion of 2.5 M NaCl at 0.1 mg/kg body weight · min for 30 min) and by decreased blood volume (2 successive hemorrhages of 10% of blood volume each). The vasopressin responses to these stimuli were unaffected by either intracerebroventricular (icv) atropine (10 μg; muscarinic blockade) or icv hexamethonium (10 μg; nicotinic blockade) in doses which block the vasopressin responses to icv cholinergic agonists. The implications of these findings are discussed.

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Author notes

  1. D. P. Brooks

    Present address: Department of Pharmacology, Smith, Kline and French Laboratories, King of Prussia, Pennsylvania, USA

Affiliations

  1. Department of Physiology and Biophysics, University of Tennessee-Memphis, 38163, Memphis, TN, USA

    K. Iitake, L. Share, D. P. Brooks, J. T. Crofton & Y. Ouchi

Authors
  1. K. Iitake
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  2. L. Share
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  3. D. P. Brooks
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  4. J. T. Crofton
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  5. Y. Ouchi
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Additional information

On leave from the Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan

On leave from the Third Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan

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Iitake, K., Share, L., Brooks, D.P. et al. Role of brain acetylcholine in vasopressin release during osmotic stimulation and hemorrhage. Exp Brain Res 75, 47–52 (1989). https://doi.org/10.1007/BF00248529

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  • DOI: https://doi.org/10.1007/BF00248529

Key words

  • Vasopressin release
  • Brain muscarinic receptors
  • Brain nicotinic receptors
  • Increased plasma osmolality
  • Hemorrhage