Abstract
Our approach to a study of structure-function relationships in phospholipases A2 is based upon the hypothesis that these enzymes are related by divergent evolutionary processes. Accordingly, characterization of such enzymes, which exhibit structural and functional variations, must be reconciled with a common theme that ultimately relates to mechanism. Our focus in the present communication concerns studies on the bee venom enzyme and a new class of phospholipases A2 that is unique in having a lysine in place of the aspartic acid at position 49.
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This article was presented during the proceedings of the International Conference on Macromolecular Structure and Function, held at the National Defence Medical College, Tokorozawa, Japan, December 1985.
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Maraganore, J.M., Poorman, R.A. & Heinrikson, R.L. Phospholipases A2: Variations on a structural theme and their implications as to mechanism. J Protein Chem 6, 173–189 (1987). https://doi.org/10.1007/BF00247765
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DOI: https://doi.org/10.1007/BF00247765