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The effect of salt administration on the renal protein-bound sulfhydryl concentration in the rat

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Summary

The oral administration of ammonium chloride, sodium bicarbonate or hypertonic sodium chloride to rats caused a decrease in renal cellular protein-bound sulfhydryl (PBSH). A similar effect can be produced by dehydration or the injection of vasopressin. Isotonic saline administration did not produce these PBSH changes or did ammonium chloride or hypertonic sodium chloride produce PBSH changes in hypophysectomized rats. It is thus likely that these salts produced a discharge of antidiuretic hormone via the supraoptico-hypophysial system which in turn produced the PBSH changes described.

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Authors and Affiliations

  1. Upstate Medical Center, Department of Pharmacology, State University of New York, Syracuse, N.Y.

    Alfred Farah

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  1. Alfred Farah
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Additional information

Dedicated to Professor Otto Krayer on his 65th birthday.

This investigation was supported by United States Public Health Service grant A-2232(C3) from the National Institute of Arthritis and Metabolic Diseases.

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Farah, A. The effect of salt administration on the renal protein-bound sulfhydryl concentration in the rat. Naunyn - Schmiedebergs Arch 248, 1–8 (1964). https://doi.org/10.1007/BF00247054

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  • DOI: https://doi.org/10.1007/BF00247054

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