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Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor

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Summary

Both interleukin 1α (IL-1α) and tumor necrosis factor α (TNFα) stimulated the production of interleukin 8 (IL-8) by synovial cells in time and dose dependent manners. Enhanced chemotactic activity of polymorphonuclear cells (PMN) in culture supernatants of synovial cells was neutralized with anti-IL-8 antibody, thus showing synovial cells to be capable of secreting IL-8 which may contribute to PMN accumulation in rheumatoid inflamed joints.

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Authors and Affiliations

  1. Department of Internal Medicine, Kitasato University School of Medicine, 1-15-1, Kitasato, 228, Sagamihara, Kanagawa, Japan

    K. Hirota, T. Akahoshi, H. Endo & H. Kondo

  2. Institute of Rheumatology, Tokyo Women's Medical College, 9-12 Wakamatsucho, Shinjuku-ku, Tokyo, Japan

    S. Kashiwazaki

Authors
  1. K. Hirota
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  2. T. Akahoshi
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  3. H. Endo
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  4. H. Kondo
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  5. S. Kashiwazaki
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Hirota, K., Akahoshi, T., Endo, H. et al. Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor. Rheumatol Int 12, 13–16 (1992). https://doi.org/10.1007/BF00246871

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  • DOI: https://doi.org/10.1007/BF00246871

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