Zusammenfassung
Schilddrüsen und Trachea PTU-behandelter Meerschweinchen reagieren nach Absetzen einer 3- bis 50 tägigen Behandlung mit 100 mg/kg Natriumperchlorat pro Tag mit einer signifikanten Erhöhung der Anreicherung von Jodid-131. Diese Erhöhung tritt bei der Schilddrüse schon nach dreitägiger, bei der Trachea erst nach 20 tägiger Behandlung auf. Diese Unterschiede und verschiedene Deutungsmöglichkeiten des Perchlorateffektes werden diskutiert.
Summary
Male guinea-pigs, received daily injections of 100 mg/kg NaClO4 for 3 to 50 days. PTU-blocked thyroids and tracheal segments of these animals have a significantly elevated iodine accumulation after stopping the perchlorate treatment as compared with untreated controlls.
Whereas in the thyroid this effect appeared first after 3 days treatment, in the treachea there was needed at least 20 days of treatment with perchlorate to produce this effect. This difference and the possible mechanism of perchlorate action are subject of the discussion.
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Hackenthal, E., Allmann, A. & Morgenstern, I. Die Jodidaufnahme der Schilddrüse und der Trachea des Meerschweinchens während und nach chronischer Perchloratbehandlung. Naunyn - Schmiedebergs Arch 252, 368–378 (1966). https://doi.org/10.1007/BF00246751
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DOI: https://doi.org/10.1007/BF00246751