Summary
1. An experimental congestion edema was produced in rats by tying of both jugular veins. During 22 hours after the operation the animals were loaded three times with 5 ml./100 g body weight 0,9% saline per os. Each animal received 1000 mU/kg. Syntocinon s.c. one half hour before each fluid loading.
2. Oxytocin produced a diuretic and saluretic effect in intact animals and animals with tied jugular veins. The development of congestion edema was reduced 50% by oxytocin.
3. On the basis of experimental effects of oxytocin on man and experimental animals, it is possible and probable that oxytocin is involved in the regulation of adrenal cortical secretion.
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Horster, F.A. Die Wirkung von Oxytocin auf die renale Ausscheidung und auf die Ausbildung eines Stauungsödems bei der Ratte. Naunyn - Schmiedebergs Arch 240, 162–170 (1960). https://doi.org/10.1007/BF00246620
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DOI: https://doi.org/10.1007/BF00246620