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Zur Wirkung insecticider chlorierter Kohlenwasserstoffe auf das Zentralnervensystem von Ratten

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Summary

DDT, gamexane, dieldrin and toxaphene were studied for their activity on the nervous system in the rat. Gamexane increases the glutamine brain content markedly and it is suggested that the anticonvulsive effect of gamexane against metrazole may be related to the increase in glutamine. DDT slightly increases brain glutamine content giving also weaker protection against metrazole convulsions. Dieldrin slightly increased glutamic acid and toxaphene almost caused no change in glutamic acid, glutamine, γ-amino butyric acid or glutathione.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Freien Universität Berlin, Germany

    A. Ghazal

  2. Pharmacology Department, Faculty of Pharmacy, Alexandria, Egypt

    A. Ghazal

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  1. A. Ghazal
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Stipendiat der Alexander von Humboldt-Stiftung.

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Ghazal, A. Zur Wirkung insecticider chlorierter Kohlenwasserstoffe auf das Zentralnervensystem von Ratten. Naunyn - Schmiedebergs Arch 244, 504–509 (1963). https://doi.org/10.1007/BF00246572

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  • DOI: https://doi.org/10.1007/BF00246572

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