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Versuche zur Deutung des sogenannten „Vulpian-Effektes“ von Curarin

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Summary

With increasing degree of curarization the voluntary muscular action is impaired earlier than the action by indirect electrical stimulation (so called Vulpian-effect). An analysis of this phenomenon has shown, that the point of attack, responsible for the Vulpian-effect, has to be located in the region of the motor end-plate (or near the endplate region in the final terminations of the nerves). The favored paralysis of the muscle to impulses from the spinal cord does not depend on different frequencies of the nerve impulses. It depends probably on the different number of excited nerve fibres.

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Universität Göttingen, Germany

    W. D. Erdmann

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  1. W. D. Erdmann
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Durchgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Erdmann, W.D. Versuche zur Deutung des sogenannten „Vulpian-Effektes“ von Curarin. Naunyn - Schmiedebergs Arch 229, 272–280 (1956). https://doi.org/10.1007/BF00246441

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  • DOI: https://doi.org/10.1007/BF00246441

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