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Hemmung von Phosphokinasen durch das 6-Aminonicotinamid-Analoge (6ANAD) des Nicotin-Adenin-Dinucleotids (NAD)

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Zusammenfassung

Die Einwirkung in vitro von 6 ANAD, dem 6-Aminonicotinsäureamid-Analogen des NAD, auf ATP:Pyruvatphosphotransferase (Pyruvatkinase) und ATP:Kreatinphosphoryltransferase (Kreatinphosphokinase) aus Kaninchenmuskel wird untersucht. In Konzentrationen von 10−3 M hemmt 6 ANAD diese Reaktionen (in Richtung der Phosphorylierung des ADP zum ATP) um ca. 40%.

Summary

The in vitro effects of 6 ANAD, the 6-aminonicotinic acid amide-analogue of NAD, on ATP : pyruvate phosphotransferase (pyruvate kinase) and ATP:creatine phosphoryltransferase (creatine phosphokinase) of rabbit muscle was investigated. 6 ANAD inhibits these reactions performed as phosphorylations of ADP to ATP in 10−3 molar concentrations about 40 per cent.

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Abbreviations

6 ANAD:

6-Aminonicotinamid-Adenin-Dinucleotid

3 APAD:

3-Acetylpyridin-Adenin-Dinucleotid

ADP:

Adenosin-5′-diphosphat

ATP:

Adenosin-5′-triphosphat

NAD(P):

Nicotin-Adenin-Dinucleotid(-Phosphat).

Literatur

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Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Freien Universität Berlin, Berlin-Dahlem

    Franz von Bruchhausen

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  1. Franz von Bruchhausen
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von Bruchhausen, F. Hemmung von Phosphokinasen durch das 6-Aminonicotinamid-Analoge (6ANAD) des Nicotin-Adenin-Dinucleotids (NAD). Naunyn - Schmiedebergs Arch 247, 87–92 (1964). https://doi.org/10.1007/BF00246344

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  • DOI: https://doi.org/10.1007/BF00246344

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