Summary
1. The influence of experimental liver injury has been compared on distinct enzymatic oxidations in microsomes and mitochondria. Oxidative reactions in these two cellfractions can be damaged independently on each other. There is no rule that the energy supplying oxidative system in mitochondria is inhibited earliest.
2. Inhibition of O2-consumption or oxidative phosphorylation can not be observed in all cases of experimental induced fatty degeneration of liver.
Uncoupling of respiration and phosphorylation is neither the general cause nor the unavoidable consequence of fatty degeneration.
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Neubert, D., Maibauer, D. Vergleichende Untersuchungen der oxydativen Leistungen von Mitochondrien und Mikrosomen bei experimenteller Leberschädigung. Naunyn - Schmiedebergs Arch 235, 291–300 (1959). https://doi.org/10.1007/BF00246011
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DOI: https://doi.org/10.1007/BF00246011