Skip to main content
SpringerLink
Log in

Der beschleunigte Abbau von Pharmaka in den Lebermikrosomen unter dem Einfluß von Luminal

  • Published:
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie Aims and scope Submit manuscript

Summary

The microsomes of rats treated with Phenobarbital (Luminal) oxidize Hexobarbital (Evipan) and demethylate Methylaminoantipyrin (M. A. A.) with a much higher rate than microsomes of untreated rats. Correspondingly the duration of anaesthesia with Hexobarbital is significantly shortened in treated rats. One injection of 100 mg./kg. Phenobarbital s.c. is sufficient to accelerate the in vivo and in vitro oxidation of Hexobarbital and the in vitro demethylation of M. A. A. After a delay of about 12 hours the speed of oxidation rises, reaches its maximum after 2 days, and decreases in 5–7 days to normal values.

Comparing the microsomes of male and female rats those of the males have an oxidative activity 3–4 times higher.

The duration of Hexobarbital anaesthesia of rabbits and mice after just 1 injection of Phenobarbital is shortened in a similar manner. Comparably the concentration of Hexobarbital decreases in the blood of rabbits with a much higher rate, if these animals were treated with Phenobarbital.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Axelrod, J.: J. Biol. Chem. 214, 753 (1955).

    Google Scholar 

  • Brodie, B. B., and J. Axelrod: J. Pharmacol. exp. Ther. 99, 171 (1950).

    Google Scholar 

  • Cook, L., E. Macko and E. J. Fellows: J. Pharmacol. exp. Ther. 112, 382 (1954).

    Google Scholar 

  • Cooper, J. R., and B. B. Brodie: J. Pharmacol. exp. Ther. 114, 409 (1955).

    Google Scholar 

  • Herken, H., D. Maibauer u. D. Neubert: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 233, 139 (1958).

    Google Scholar 

  • Hoffmann, W.: unveröffentlichte Untersuchungen.

  • Holck, H. G. O., M. A. Kañan, L. M. Mills and E. L. Smith: J. Pharmacol. exp. Ther. 60, 323 (1957).

    Google Scholar 

  • LaDu, B. N., L. Gaudette, N. Trousof and B. B. Brodie: J. Biol. Chem. 214, 741 (1955).

    Google Scholar 

  • Mitoma, Ch., H. S. Posner, H. C. Reitz and S. Udenfriend: Arch. Biochem. 61, 431 (1956).

    Google Scholar 

  • Neubert, D., u. H. Herken: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 225, 453 (1955).

    Google Scholar 

  • Quinn, G. P., J. Axelrod and B. B. Brodie: Fed. Proc. 13, 396 (1954).

    Google Scholar 

  • Remmer, H.: Naturwissenschaften 45, 189 (1958a).

    Google Scholar 

  • Remmer, H.: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 233, 173 (1958b).

    Google Scholar 

  • Remmer, H.: Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 233, 184 (1958c).

    Google Scholar 

  • Remmer, H.: Naturwissenschaften 45, 522 (1958d).

    Google Scholar 

  • Remmer, H.: e) unveröffentlichte Untersuchungen.

  • Remmer, H., u. B. Alsleben: Klin. Wschr. 36, 332 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aus dem Pharmakologischen Institut der Freien Universität Berlin, Germany

    H. Remmer

Authors
  1. H. Remmer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Mit 9 Textabbildungen

Die Untersuchungen wurden durch eine Sachbeihilfe der Deutschen Forschungsgemeinschaft ermöglicht.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Remmer, H. Der beschleunigte Abbau von Pharmaka in den Lebermikrosomen unter dem Einfluß von Luminal. Naunyn - Schmiedebergs Arch 235, 279–290 (1959). https://doi.org/10.1007/BF00246010

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00246010

Search

Navigation