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Biologische Wirkungen des Liquor cerebrospinalis und ihre Veränderungen bei erhöhter Hirnaktivität

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Zusammenfassung

Die biologische Wirkung des Liquor cerebrospinalis des Kaninchens wurde am M. rectus abdominis sowie am isolierten Herzen des Frosches untersucht. In Übereinstimmung mit Feldberg u. Mitarb. (1956/57) findet sich im Liquor ein Faktor, welcher zwar am M. rectus abdominis keine Kontraktionen auslöst, aber den Muskel gegenüber Acetylcholin sensibilisiert. Entsprechend konnten wir nachweisen, daß der Liquor cerebrospinalis auch das isolierte Herz gegenüber der inotropen und chronotropen Wirkung von Acetylcholin sensibilisiert. Schließlich übt der Liquor eine positiv-inotrope Wirkung auf das isolierte Herz aus; diese ist nicht durch die biogenen Amine Adrenalin, Noradrenalin, Serotonin und Histamin bedingt. Während einer erhöhten Hirnaktivität infolge Reizung des aufsteigenden Retikularsystemes nimmt diese positivinotrope Wirkung signifikant zu. Diese Wirkung könnte auf einem Stoffwechselmetaboliten des Gehirns beruhen.

Summary

The biological activity of rabbit's cerebrospinal fluid was tested on both, the M. rectus abdominis and the isolated frog heart. According to Feldberg and cowoker (1956/57) the cerebrospinal fluid contains a biological factor, which sensitises the rectus muscle to acetylcholine, but does not elicit itself contractions. Similarly we demonstrated that the cerebrospinal fluid sensitises the isolated heart to the inotropic and chronotropic effect of acetylcholine. Furthermore it has a positive inotropic action on this isolated organ; this effect is not related to biogenic amines such as adrenaline, noradrenaline, serotonine or histamine. The described positive inotropic effect on the heart is significantly increased by cerebrospinal fluid from aroused rabbits, following stimulation of the reticular activating system. This effect is presumably related to some brain metabolite.

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Literatur

  • Bhattacharya, B. K., W. Feldberg, and W. Vogt: Some properties of the substance in human cerebrospinal fluid sensitizing the frog rectus muscle to acetylcholine. J. Physiol. (Lond.) 137, 460–472 (1957).

    Google Scholar 

  • Bowers, M. R.: Stimulation and sensitization of the isolated venous heart by cerebrospinal fluid. Brit. J. Pharmacol. 19, 295–298 (1962).

    Google Scholar 

  • Carmichael, E. A., W. Feldberg, and K. Fleischauer: The site of origin of the tremor produced by tubocurarine acting from the cerebral ventricles. J. Physiol. (Lond.) 162, 539–554 (1962).

    Google Scholar 

  • Cobbin, L. B., and R. H. Thorp: The cardio—active principle in spleen. Brit. J. Pharmacol. 14, 392–400 (1954).

    Google Scholar 

  • Czubalski, F., R. Kordecki, and J. Panasewicz: Influence of small doses of histamine on the activity of isolated heart. Acta physiol. pol. 5, 565–570 (1954).

    Google Scholar 

  • Feldberg, W., J. W. Malcolm, and S. L. Sherwood: Some effects of tubocurarine on the electrical activity of the cat's brain. J. Physiol. (Lond.) 132, 130–142 (1956).

    Google Scholar 

  • Green, J. P., and L. H. Nahum: Effects of liver fractions on myocardial contractility. Circulat. Res. 5, 634–640 (1957).

    Google Scholar 

  • Loubatières, A., A. Sassine et J. Mauche: Contribution à l'étude sur le coeur de la 5-hydroxytryptamine. C. R. Soc. Biol. (Paris) 149, 1634–1636 (1955).

    Google Scholar 

  • Magoun, H. W.: The Waking Brain. Springfield: Thomas 1958.

    Google Scholar 

  • Manger, W., B. Schwarz, C. Baars, K. Wakim, J. Bollman, M. Petersen, and J. Berkson: Epinephrine and arterenol (norepinephrine) in mental disease. Arch. Neurol. Psychiat. (Chic.) 78, 396–412 (1957).

    Google Scholar 

  • Marley, E.: Release of an adrenaline-like substance by electrical stimulation of the brain stem. In: Adrenergic mechanisms. Ciba Found. Symp. 424–427, Publ. Churchill, Lond. 1960.

    Google Scholar 

  • Mitchel, J. P.: The spontaneous and evoked release of acetylcholine from the cerebral cortex. J. Physiol. (Lond.) 165, 98–116 (1963).

    Google Scholar 

  • Monnier, M., and H. Gangloff: Rabbit Brain Research. Vol. I: Atlas for stereotaxic brain research on the conscious rabbit. Amsterdam: Elsevier Publ. Comp. 1961.

    Google Scholar 

  • —, and S. Graber: Humoral influences of induced sleep and arousal upon electrical brain activity of animals with crossed circulation. Exp. Neurol. 8, 264–277 (1963).

    Google Scholar 

  • Purpura, D. P.: A neurohumoral mechanism of reticulo-cortical activation. Amer. J. Physiol. 186, 250–254 (1956).

    Google Scholar 

  • Scavo, J.: Le sostanze antidiuretiche dei liquidi organici (Sintesi critici). Rass. Fisiopath. Clin. ter. 26, 773–798 (1954).

    Google Scholar 

  • Schain, R. J.: Neurohumors and other pharmacologically active substances in cerebrospinal fluid: A review of the literature. Yale J. Biol. Med. 33, 15–36 (1960).

    Google Scholar 

  • —: Action of pharmacologically active substances in cerebrospinal fluid upon the central nervous system. Wld Neurol. 3, 706–716 (1962).

    Google Scholar 

  • Vogt, M.: The concentration of sympathin in different parts of the central nervous system under normal conditions and after administration of drugs. J. Physiol. (Lond.) 123, 451–481 (1954).

    Google Scholar 

  • West, G. B.: A comparative biological essay of activity in single solutions of adrenaline. J. Physiol. (Lond.) 102, 367–371 (1943).

    Google Scholar 

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Basel, Germany

    W. Romanowski, P. Krupp & M. Monnier

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  1. W. Romanowski
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  2. P. Krupp
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  3. M. Monnier
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Mit 8 Textabbildungen

Dozent an der Medizinischen Akademie Warschau.

Wir möchten der Direktion der wissenschaftlichen Abteilung der Hoffmann-La Roche A. G., Basel, sowie dem Ciba Fonds, Basel, unseren herzlichsten Dank für die Unterstützung dieser Arbeit aussprechen.

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Romanowski, W., Krupp, P. & Monnier, M. Biologische Wirkungen des Liquor cerebrospinalis und ihre Veränderungen bei erhöhter Hirnaktivität. Naunyn - Schmiedebergs Arch 247, 214–228 (1964). https://doi.org/10.1007/BF00245965

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