Summary
In suspensions of red cells of dogs p-chloronitrosobenzene is more stable than nitrosobenzene. It produces hemiglobin at a slower rate than nitrosobenzene does. The relevance of these findings for explaining the accumulation of p-chloronitrosobenzene in the blood of dogs injected with p-chloroaniline has been discussed.
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Literature
Haan, J., M. Kiese u. A. Werner: Reduktion von Nitrosobenzol zu Anilin in roten Blutzellen. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 235, 365 (1959).
Kiese, M.: Effect of Certain Substituents upon the N-Oxidation of Aniline in vivo. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 244, 387 (1963).
— D. Reinwein u. H. D. Waller: Die Hämiglobinbildung durch Phenylhydroxylamin und Nitrosobenzol in roten Zellen in vitro. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 210, 393 (1950).
— C. Schneider u. H. D. Waller: Hämiglobinreductase. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 231, 158 (1957).
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Kiese, M. The reduction of p-chloronitrosobenzene in the red cells of dogs. Naunyn - Schmiedebergs Arch 245, 484–486 (1963). https://doi.org/10.1007/BF00245791
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DOI: https://doi.org/10.1007/BF00245791