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Cardiovascular actions of the hypotensive agent, N, N-diallylmelamine (U-7720)

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Summary

Diallylmelamine is an effective hypotensive agent in hypertensive dogs and rats, having a duration of action exceeding twenty-four hours from a single oral dose. It has limited efficacy in normotensive rats. Hypotensive activity of gradual onset is preceded by a latent period of up to two hours and becomes maximal six hours or more after dosing. This agent does not depress cardiac output or sympathetic vasoconstrictor activity. It is suggested that its hypotensive activity results from a direct effect upon vascular smooth muscle.

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References

  • Freyburger, W. A., J. R. Weeks, and E. Smits: Hypotensive action of N,N-diallylmelamine (U-7720) in trained unanesthetized dogs. Pharmacologist 4, 165 (1962).

    Google Scholar 

  • Goldblatt, H., J. Lynch, R. F. Hanzal, and W. W. Summerville: Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J. exp. Med. 59, 347 (1934).

    Google Scholar 

  • Grollman, A.: A simplified procedure for inducing chronic renal hypertension in the mammal. Proc. Soc. exp. Biol. (N. Y.) 57, 102 (1944).

    Google Scholar 

  • Heatley, N. G., and J. R. Weeks: Fashioning polyethylene tubing for use in physiological experiments. J. appl. Physiol. 19, 542 (1964).

    Google Scholar 

  • Leersum, E. C. van: Eine Methode zur Erleichterung der Blutdruckmessung bei Tieren. Pflügers Arch. ges. Physiol. 142, 377 (1911).

    Google Scholar 

  • Maxwell, R. A., A. J. Plummer, and M. W. Osborne: Studies with the ganglionic blocking agent, chlorisondamine chloride in unanesthetized and anesthetized dogs. Circulat. Res. 4, 276 (1956).

    Google Scholar 

  • Weeks, J. R., and J. A. Jones: Routine direct measurement of arterial pressure in unanesthetized rats. Proc. Soc. exp. Biol. (N. Y.) 104, 646 (1960).

    Google Scholar 

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Author notes

  1. Donald W. Ducharme

    Present address: Department of Pharmacology, Medical School, University of Michigan, Ann Arbor, Michigan

Authors and Affiliations

  1. From the Pharmacology Research Laboratories, The Upjohn Company Kalamazoo, Michigan

    Walter A. Freyburger, James R. Weeks & Donald W. Ducharme

Authors
  1. Walter A. Freyburger
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  2. James R. Weeks
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  3. Donald W. Ducharme
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With 3 Figures in the Text

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Freyburger, W.A., Weeks, J.R. & Ducharme, D.W. Cardiovascular actions of the hypotensive agent, N, N-diallylmelamine (U-7720). Naunyn - Schmiedebergs Arch 251, 39–47 (1965). https://doi.org/10.1007/BF00245728

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  • DOI: https://doi.org/10.1007/BF00245728

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