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Beeinflussung der Blutdruckwirkung von Angiotensin durch Aminopeptidasen und Carboxypeptidase

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Summary

1. The pressor effect of angiotensin II was reduced after intravenous injections or infusions in spinal cats of several aminopeptidases and carboxypeptidase A.

2. The short half life of the enzymes in cats was the reason of the relatively transient effect. The half life of leucine aminopeptidase (LAP) and aminopeptidase from pig kidneys (AP-M) was 4–6 min, of carboxy-peptidase A 50–80 min and of aminopeptidase from aspergillus (AP-Asp.) 10–20 min.

3. The increase of enzyme concentrations in the blood of cats was in correlation with the decrease of the angiotensin pressor effect.

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Literatur

  • Erdös, E. G., J. R. Wohler, and M. J. Levine: Blocking of the in vivo effects of bradykinin and kallidin with carboxypeptidase B. J. Pharmacol. exp. Ther. 142, 327 (1963).

    Google Scholar 

  • Folk, J. E., and J. A. Gladner: Carboxypeptidase. J. biol. Chem. 231, 379 (1958).

    Google Scholar 

  • Klaus, D.: Untersuchungen über die Angiotensinase im Serum Gesunder und Kranker. Klin. Wschr. 40, 701 (1962).

    Google Scholar 

  • —, and P. Biron: Electrophoretic behaviour of serum angiotensinase. Nature (Lond.) 204, 381 (1964).

    Google Scholar 

  • — H. Kaffarnik u. H. Pfeil: Untersuchungen über die Serum-Angiotensinase. Klin. Wschr. 41, 376 (1963).

    Google Scholar 

  • Loyke, H. F., and J. S. Mackrell: Effect of liver damage on experimental desoxycorticosterone hypertension in the rat. J. Lab. clin. Med. 58, 871 (1961).

    Google Scholar 

  • Meakins, J. C.: Jaundice and blood pressure. Med. Clin. N. Amer. 16, 715 (1932).

    Google Scholar 

  • Pfleiderer, G., u. P. Celliers: Isolierung einer Aminopeptidase aus Nierenpartikeln. Biochem. Z. 339, 186 (1963).

    Google Scholar 

  • Raaschou, Fl.: Liver function and hypertension. Circulation 10, 511 (1954).

    Google Scholar 

  • —, and K. Trautner: Obstruction of the common bile duct in experimental renal hypertension in dogs. Scand. J. clin. Lab. Invest. 5, 223 (1953).

    Google Scholar 

  • Riedel, A., u. E. Wünsch: N-α-Benzoyl-arginin-β-naphthylamid als Substrat zur quantitativen colorimetrischen Bestimmung von Trypsin. Hoppe-Seylers Z. physiol. Chem. 316, 61 (1959).

    Google Scholar 

  • Smith, E. L.: In: S. P. Colowick and N. O. Kaplan: Methods in Enzymology, Vol. II, p. 83, New York: Academic Press 1955.

    Google Scholar 

  • Tuppy, H., u. H. Nesvadba: Über die Aminopeptidaseaktivität des Schwangerenserums und ihre Beziehung zu dessen Vermögen Oxytocin zu inaktivieren. Mh. Chem. (Wien) 88, 977 (1957).

    Google Scholar 

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Authors and Affiliations

  1. Aus der Medizinischen Universitätspoliklinik Tübingen und dem Pharmakologischen Institut der Universität Tübingen, Germany

    D. Klaus, A. Heizmann & H. Uehleke

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  1. D. Klaus
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  2. A. Heizmann
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  3. H. Uehleke
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Referat der 28. Tagung der Deutschen Pharmakologischen Gesellschaft vom 5. bis 8. Oktober 1964 in Bad Nauheim: Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 250, 264 (1965).

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Klaus, D., Heizmann, A. & Uehleke, H. Beeinflussung der Blutdruckwirkung von Angiotensin durch Aminopeptidasen und Carboxypeptidase. Naunyn - Schmiedebergs Arch 251, 28–38 (1965). https://doi.org/10.1007/BF00245727

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  • DOI: https://doi.org/10.1007/BF00245727

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