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Renal vascular changes produced by the mercurial diuretic salyrgan

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Summary

The mercurial diuretic salyrgan produced 3 distinct types of reduction in renal blood flow and glomerular filtration. The reduction in glomerular filtration and renal plasma flow produced by hemorrhage or clamping of the aorta above the renal arteries resulted in a marked decrease in the effectiveness of the mercurial as a diuretic. The reduction in glomerular filtration is probably the more important factor in this refractoriness to the mercurial.

In the light of these findings and others brought out in the discussion, the refractory state of the kidney to mercurial diuretics has been discussed.

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Authors and Affiliations

  1. Dept. of Pharmacology, State University of New York at Syracuse, College of Medicine, USA

    Alfred Farah

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  1. Alfred Farah
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Additional information

In honor of Professor Wolfgang Heubner on his 75th birthday.

With 3 Figures in the Text.

Supported by a grant from the Hendricks Research Fund, Syracuse N. Y. and Ciba Pharmaceutical Company, Summit, New Jersey.

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Farah, A. Renal vascular changes produced by the mercurial diuretic salyrgan. Naunyn - Schmiedebergs Arch 215, 29–38 (1952). https://doi.org/10.1007/BF00245583

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  • DOI: https://doi.org/10.1007/BF00245583

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