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Der Einfluß des Lebensalters auf Umsetzungen von Phenacetin, p-Phenetidin, N-Acetyl-p-aminophenol, p-Aminophenol und Anilin im Hunde

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Literatur

  • Bartalini, E., e L. Ghiringhelli: Metaemoglobinemia e coproporfirinuria nell' intossicazione sperimentale da anilina. Med. d. Lavoro 44, 88 (1953).

    Google Scholar 

  • Bartalini, E., and L. Ghiringhelli: Methemoglobinemia and coproporphyrinuria in aniline poisoning. Arch. za higijenu rada 4, 121 (1953).

    Google Scholar 

  • Bernheim, F., M. L. C. Bernheim and H. O. Michel: The action of p-aminophenol on certain tissue oxidations. J. Pharmacol. exp. Ther. 61, 311 (1937).

    Google Scholar 

  • Brändle, W., u. M. Kiese: Noch nicht abgeschlossene Untersuchungen. Tübingen 1960.

  • Brodie, B. B., and J. Axelrod: The fate of acetanilide in man. J. Pharmacol. exp. Ther. 94, 29 (1948b).

    Google Scholar 

  • Brodie, B. B., and J. Axelrod: The estimation of acetanilide and its metabolic products, aniline, N-acetyl-p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues. J. Pharmacol. exp. Ther. 94, 22 (1948a).

    Google Scholar 

  • Brodie, B. B., and J. Axelrod: The fate of acetophenetidin (phenacetin) in man and methods for the estimation of acetophenetidin and its metabolites in biological material. J. Pharmacol. exp. Ther. 97, 58 (1949).

    Google Scholar 

  • Clark, B. B.: N-Acetyl-p-aminophenol, pharmacological studies and cardiovascular and metabolic studies in laboratory animals and man. Symposium on N-acetyl-p-aminophenol, The Institute for the Study of Analgesic and Sedative Drugs, Elkhart, Ind., 1952, S. 23.

  • Clark, B. B., J. van Loon and W. Morissey: Acute experimental aniline intoxication. J. industr. Hyg. 25, 1 (1943).

    Google Scholar 

  • Free, A. H., H. M. Free, M. H. Pindell and V. K. Pittard: Biochemical and pharmacological studies with acetyl-para-aminophenol and related compounds. Miles-Ames Research Lab., Report No. 5212, 27 (June 1952), zit. bei P. K. Smith.

  • Greenberg, L. A., and D. Lester: The metabolic fate of acetanilide and other aniline derivatives. I. Major metabolites of acetanilide appearing in the urine. J. Pharmacol. exp. Ther. 88, 87 (1947).

    Google Scholar 

  • Greenberg, L. A., and D. Lester: The metabolic fate of acetanilide and other aniline derivatives. III. The role of p-aminophenol in the production of methemoglobinemia after acetanilide. J. Pharmacol. exp. Ther. 90, 150 (1947).

    Google Scholar 

  • Ghiringhelli, L.: Rapporti tra metaemoglobinemia e catalasi nell' intossicazione sperimentale da anilina. Med. d. Lavoro 43, 272 (1952).

    Google Scholar 

  • Ghiringhelli, L., e C. Molina: La metaemoglobinemia nell' intossicazione acuta da anilina nell' animale da esperimento e nell' uomo. Suoi rapporti colla cianosi, l'anemia e i corpi di Heinz. Med. d. Lavoro 42, 125 (1951).

    Google Scholar 

  • Haan, J., M. Kiese u. A. Werner: Reduktion von Nitrosobenzol zu Anilin in roten Blutzellen. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 235, 365 (1959).

    Google Scholar 

  • Hauschild, F.: Die Wirkung des Katalytins (Thionin) bei der Methämoglobinvergiftung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 184, 458 (1937).

    Google Scholar 

  • Herr, F., u. M. Kiese: Bestimmung von Nitrosobenzol im Blute. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 235, 351 (1959).

    Google Scholar 

  • Heubner, W.: Studien über Methämoglobinbildung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 72, 239 (1913).

    Google Scholar 

  • Heubner, W., M. Kiese, M. Stuhlmann u. W. Schwartzkopff-Jung: Der Hämiglobingehalt normalen Blutes. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 204, 313 (1947).

    Google Scholar 

  • Issekutz, B. von: Studien über Methämoglobinbildung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 193, 551 (1939).

    Google Scholar 

  • Jondorf, W. R., R. P. Maickel and B. B. Brodie: Inability of newborn mice and guinea pigs to metabolize drugs. Biochem. Pharmacol. 1, 352 (1959).

    Google Scholar 

  • Kiese, M.: Empfindliche photometrische Verfahren zur Bestimmung von Hämiglobin und Hämoglobin. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 204, 190 (1947).

    Google Scholar 

  • Kiese, M.: Oxydation von Anilin zu Nitrosobenzol im Hunde. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 235, 354 (1959a).

    Google Scholar 

  • Kiese, M.: Die Bedeutung der Oxydation von Anilin zu Nitrosobenzol für die Hämiglobinbildung nach Aufnahme von Anilin in den Organismus. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 235, 360 (1959b).

    Google Scholar 

  • Kiese, M., D. Reinwein u. H. D. Waller: Die Hämiglobinbildung durch Phenylhydroxylamin und Nitrosobenzol in roten Zellen in vitro. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 210, 393 (1950).

    Google Scholar 

  • Lester, D.: Formation of Methemoglobin. 1. Species differences with acetanilide and acetophenetidin. J. Pharmacol. exp. Ther. 77, 154 (1943).

    Google Scholar 

  • Lester, D., and L. A. Greenberg: The metabolic fate of acetanilide and other aniline derivatives. II. Major metabolites of acetanilide appearing in the blood. J. Pharmacol. exp. Ther. 90, 68 (1947).

    Google Scholar 

  • Loon, E. J. van, and B. B. Clark: Observations on the hematologic actions of acetanilide and acetophenetidin in the dog. J. Lab. clin. Med. 29, 942 (1944).

    Google Scholar 

  • Navrockij, V. K., u. J. M. Orlick: Verteilung des Anilins in tierischen Geweben. Farmakol. i Toksikol. 10, No. 3, S. 40 (1947).

    Google Scholar 

  • Oettingen, W. F. von, R. F. Sievers and B. L. Horecker: Comparison of the acute effects of orally administered xylidine and aniline on the physiological functions of dogs. Nat. Inst. Hlth Bull. No. 188, 7 (1947).

    Google Scholar 

  • Renault, H., P. Rohrbach et J. Dugniolle: Propriétés pharmacodynamiques du N-acétyl-para-aminophenol, métabolite de la phénacétine et de l'acétanilide. Thérapie 11, 300 (1956).

    Google Scholar 

  • Roche, J.: Sur l'action physiologique de la méthémoglobinisation du sang. Arch. int. Pharmacodyn. 37, 358 (1930).

    Google Scholar 

  • Smith, J. N., and R. T. Williams: The metabolism of acetanilide in the rabbit. Biochem. J. 42, 538 (1948).

    Google Scholar 

  • Smith, J. N., and R. T. Williams: The metabolism of phenacetin (p-ethoxy-acetanilide) in the rabbit and a further observation on acetanilide metabolism. Biochem. J. 44, 239 (1949).

    Google Scholar 

  • Smith, P. K.: Acetophenetidin, a critical bibliographic review. New York 1958.

  • Spicer, S. S.: Species differences in susceptibility to methemoglobin formation. J. Pharmacol. exp. Ther. 99, 185 (1950).

    Google Scholar 

  • Spicer, S. S., and P. A. Neal: The effect of hypoxia on the in vivo formation of methemoglobin by aniline and nitrite. J. Pharmacol. exp. Ther. 95, 438 (1949).

    Google Scholar 

  • Vandenbelt, J. M., C. Pfeiffer, M. Kaiser and M. Sibert: Methemoglobinemia after administration of p-aminoacetophenone and p-aminopropiophenone. J. Pharmacol. exp. Ther. 80, 31 (1944).

    Google Scholar 

  • Wertheimer, E., et E. Meyer: Influence de l'aniline et des toluidines sur la capacité respiratoire du sang et sur la temperature. C. R. Soc. Biol. (Paris) 1889, 10.

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Baader, H., Girgis, S., Kiese, M. et al. Der Einfluß des Lebensalters auf Umsetzungen von Phenacetin, p-Phenetidin, N-Acetyl-p-aminophenol, p-Aminophenol und Anilin im Hunde. Naunyn - Schmiedebergs Arch 241, 317–334 (1961). https://doi.org/10.1007/BF00245066

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  • DOI: https://doi.org/10.1007/BF00245066

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