Summary
Transient stop of respiration in exspiratory position can be produced in cats by intravenous injection of chlorpromazine, promethazine, and diethazine. The effect is dependend on the velocity of injection and on the concentration of the injected solution. Furthermore, it is most powerfull after administration into the arteria pulmonalis, but cannot be recognised after injection into the vena pulmonalis or into the bulbus aortae. It is abolished by vagotomia, but not by cooling both vagi to 6°C. Records of afferent vagal impulses at this temperature don't provide evidence for activation of lung stretch receptors. The alterations of blood pressure in the arteria et vena pulmonalis develop slowly and are only small. Therefore the chemosensible pulmonary vascular receptors are supposed to be chiefly involved in the reflectory stop of respiration after chlorpromazine, promethazine, and diethazine.
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Wellhöner, HH., Hartmann, H. & Hauschild, F. Zum Mechanismus des reflektorischen Atemstillstandes nach intravenöser Injektion von Chlorpromazin. Naunyn - Schmiedebergs Arch 240, 224–233 (1960). https://doi.org/10.1007/BF00244840
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DOI: https://doi.org/10.1007/BF00244840