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The human plasma fibrinolytic system: Regulation and control

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Summary

The factors involved in the regulation and control of the human plasma fibrinolytic system at the cellular level are unknown at this time. The physiological regulation of plasmin formation in plasma depends primarily on the nature of the circulating zymogen, plasminogen, the physiological activators formed both in the blood and in the vascular endothelium, and the specific plasmin inhibitors found both in plasma and in certain of the cellular elements of the blood. The biosynthesis of the zymogen must be under genetic control, and the activators are probably released, after thrombus and clot formation, from components involved in the surface-mediated initiation of the coagulation system, and from the vascular endothelium. Activation of plasminogen can occur both in the fluid phase surrounding the thrombus and probably at thrombus surfaces, involving both the fibrin clot and the platelet membrane. The plasmin inhibitors act to control the system in order to prevent proteolytic degradation of important physiological trace proteins of the coagulation, complement and kallikrein-kinin systems by the enzyme.

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Authors and Affiliations

  1. Michael Reese Research Foundation, 530 East 31st Street, 60616, Chicago, Illinois

    Kenneth C. Robbins Ph.D. (Scientific Director)

  2. Departments of Medicine and Pathology, Pritzker School of Medicine, The University of Chicago, 60637, Chicago, Illinois

    Kenneth C. Robbins Ph.D. (Scientific Director)

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  1. Kenneth C. Robbins Ph.D.
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Robbins, K.C. The human plasma fibrinolytic system: Regulation and control. Mol Cell Biochem 20, 149–157 (1978). https://doi.org/10.1007/BF00243761

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