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Second-order vestibular neuron morphology of the extra-MLF anterior canal pathway in the cat

Experimental Brain Research volume 97, pages 387–396 (1994)Cite this article

Abstract

Second-order vestibular neurons form the central links of the vestibulo-oculomotor three-neuron arcs that mediate compensatory eye movements. Most of the axons that provide for vertical vestibulo-ocular reflexes ascend in the medial longitudinal fasciculus (MLF) toward target neurons in the oculomotor and trochlear nuclei. We have now determined the morphology of individual excitatory second-order neurons of the anterior semicircular canal system that course outside the MLF to the oculomotor nucleus. The data were obtained by the intracellular horseradish peroxidase method. Cell somata of the extra-MLF anterior canal neurons were located in the superior vestibular nucleus. The main axon ascended through the deep reticular formation beneath the brachium conjunctivum to the rostral extent of the nucleus reticularis tegmenti pontis, where it crossed the midline. The main axon continued its trajectory to the caudal edge of the red nucleus from where it coursed back toward the oculomotor nucleus. Within the oculomotor nucleus, collaterals reached superior rectus and inferior oblique motoneurons. Some axon branches recrossed the midline within the oculomotor nucleus and reached the superior rectus motoneuron subdivision on that side. Since these neurons did not give off a collateral toward the spinal cord, they were classified as being of the vestibulo-oculomotor type and are thought to be involved exclusively in eye movement control. The signal content and spatial tuning characteristics of this anterior canal vestibulo-oculomotor neuron class remain to be determined.

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Affiliations

  1. Department of Physiology, Tokyo Medical College, 6-1-1 Shinjuku, Shinjuku-ku, 160, Tokyo, Japan

    Y. Uchino, M. Sasaki & M. Imagawa

  2. Department of Information and Knowledge Engineering, Faculty of Engineering, Tottori University, 4-10 Koyama-minami, Tottori-shi, 680, Tottori, Japan

    N. Isu

  3. Department of Physiology, Kyorin University, School of Medicine, Shinkawa 6-20-2, Mitaka-shi, 181, Tokyo, Japan

    N. Hirai

  4. Department of Orthopedic Surgery, Tokyo Medical College, 6-1-1 Shinjuku, Shinjuku-ku, 160, Tokyo, Japan

    K. Endo

  5. The Rockefeller University, 10021, New York, NY, USA

    W. Graf

Authors
  1. Y. Uchino
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  2. M. Sasaki
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  3. N. Isu
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  4. N. Hirai
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  5. M. Imagawa
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  6. K. Endo
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  7. W. Graf
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Uchino, Y., Sasaki, M., Isu, N. et al. Second-order vestibular neuron morphology of the extra-MLF anterior canal pathway in the cat. Exp Brain Res 97, 387–396 (1994). https://doi.org/10.1007/BF00241532

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  • DOI: https://doi.org/10.1007/BF00241532

Key words

  • Eye movement
  • Horseradish peroxidase
  • Semicircular canals
  • Three-neuron arc
  • Vestibulo-ocular reflex
  • Cat