Abstract
In cerebral ischemia of different degrees, the amplitudes of somatosensory evoked potentials (SEPs) are facilitated or depressed. Different mechanisms might be responsible for the explanation of the contradictory phenomena. SEPs obtained using the paired stimulation method were employed in trying to find out the role of the functional changes of the inhibitory system in the brain during ischemia. Eight rabbits were used for recording the amplitude recovery curve of paired SEPs in the normal state, and the other ten were used for recording the recovery curve in different cerebral ischemic degrees. Cerebral ischemia was induced by the iron particle injection method. The attenuation of the depressed recovery function of the paired SEP amplitudes was detected during cerebral ischemia when SEP amplitudes were either facilitated or depressed. The results indicate that the function of the inhibitory system in the brain is selectively vulnerable during cerebral ischemia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allison T (1962) Recovery functions of somatosensory evoked responses in man. Electroencephalogr Clin Neurophysiol 14: 331–343
Berg-Johnsen J, Paulsen RE, Fonnum F, Langmoen IA (1993) Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex. Exp Brain Res 96: 241–246
Branston NM, Symon L, Crockard HA, Pasztor E (1974) Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 45: 195–208
Branston NM, Ladds A, Symon L, Wang AD (1984) Comparison of the effects of ischemia on early components of the somatosensory evoked potential in brainstem, thalamus, and cerebral cortex. J Cereb Blood Flow Metab 4: 68–81
Clark DL, Rosner BS (1973) Neurophysiologic effects of general anesthetics. I. The electroencephalogram and sensory evoked responses in man. Anesthesiology 38: 564–582
García-Ugalde G, Galarraga E, Bargas J, Brailowsky S (1992) Hyperexcitability of hippocampal CA1 region in brain slices after GABA withdrawal. Neurosci Lett 147: 229–232
Greenwood PM, Goff WR (1987) Modification of median nerve somatic evoked potentials by prior median nerve, peroneal nerve, and auditory stimulation. Electroencephalogr Clin Neurophysiol 68: 295–302
Helfaer MA, Kirsch JR, Traystman RJ (1990) Anesthetic modulation of cerebral hemodynamic and evoked responses to transient middle cerebral artery occlusion in cats. Stroke 21: 795–800
Iragui-Madoz VJ, Wiederholt WC (1977) Far-field somatosensory evoked potentials in the cat: correlation with depth recording. Ann Neurol 1: 569–574
Isozumi K, Fukuuchi Y, Takeda H, Itoh Y (1994) Cerebral ischemia-induced amplification phenomenon of somatosensory evoked potentials in cats. Neurosci Lett 169: 203–206
Joy RM, Albertson TE (1993) NMDA receptors have a dominant role in population spike-paired pulse facilitation in the dentate gyrus of urethane-anesthetized rats. Brain Res 604: 273–282
Lee CJ, Whitsel BL, Tommerdahl M (1992) Mechanisms underlying somatosensory cortical dynamics. II. In vitro studies. Cereb Cortex 2: 107–133
Li C-L, Cullen C, Jasper HH (1956) Laminar microelectrode studies of specific somatosensory cortical potentials. J Neurophysiol 19: 111–130
McLaughlin DF, Kelly EF (1993) Evoked potentials as indices of adaptation in the somatosensory system in humans: a review and prospectus. Brain Res Brain Res Rev 18: 151–206
McPherson RW, Zeger S, Traystman RJ (1986) Relationship of somatosensory evoked potentials and cerebral oxygen consumption during hypoxic hypoxia in dogs. Stroke 17: 30–36
Meldrum BS, Brierley JB (1969) Brain damage in the rhesus monkey resulting from profound arterial hypotension. II. Changes in the spontaneous and evoked electrical activity of the neocortex. Brain Res 13: 101–118
Murray GM, Zhang HQ, Kaye AN, Sinnadurai T, Campbell DH, Rowe MJ (1992) Parallel processing in rabbit first (SI) and second (SII) somatosensory cortical areas: effects of reversible inactivation by cooling of SI on responses in SII. J Neurophysiol 68: 703–710
Nakashima K, Nitta T, Takahashi K (1992) Recovery functions of somatosensory evoked potentials in parkinsonian patients. J Neurol Sci 108: 24–31
Nelson SB (1991) Temporal interactions in the cat visual system. III. Pharmacological studies of cortical suppression suggest a presynaptic mechanism. J Neurosci 11: 369–380
Nilsson L, Siesjö BK (1975) The effect of phenobarbitone anesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand [Suppl] 57: 18–24
Nishijima MK, Koehler RC, Hum PD, Eleff SM, Norris S, Jacobus WE, Traystman RJ (1989) Postischemic recovery rate of cerebral ATP, phosphocreatine, PH, and evoked potentials. Am J Physiol 257: H1860–1870
Peet MJ, McLennan H (1986) Pre and postsynaptic actions of baclofen: blockage of the late synaptically-evoked hyperpolarization of CA1 hippocampal neurones. Exp Brain Res 61: 567–574
Reisin RC, Goodin DS, Aminoff MJ, Mantle MM (1988) Recovery of peripheral and central responses to median nerve stimulation. Electroencephalogr Clin Neurophysiol 69: 585–588
Sakatani K, Iizuka H, Young W (1990) Somatosensory evoked potentials in rat cerebral cortex before and after middle cerebral artery occlusion. Stroke 21: 124–132
Sasaki K, Staunton HP, Dieckmann G (1970) Characteristic features of augmenting and recruiting responses in the cerebral cortex. Exp Neurol 26: 369–392
Sasaki K, Prelević S (1972) Excitatory and inhibitory influences of thalamic stimulation on pyramidal tract neurons. Exp Neurol 36: 319–335
Shagass C, Schwartz M (1964) Recovery functions of somatosensory peripheral nerve and cerebral evoked responses in man. Electroencephalogr Clin Neurophysiol 17: 126–135
Shimada N, Graf R, Rosner G, Heiss W-D (1990) Differences in ischemia-induced accumulation of amino acids in the cat cortex. Stroke 21: 1445–1451
Skarphedinsson JO, Sandberg M, Hagberg H, Carlsson S, Thorén P (1989) Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites. J Cereb Blood Flow Metab 9: 364–372
Torp R, Arvin B, Peillet ELe, Chapman AG, Ottersen OP, Meldrum BS (1993) Effect of ischaemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87. Exp Brain Res 96: 365–376
Wang Y, Nakashima K, Shiraishi Y, Ohama E, Takahashi K (1995) Somatosensory evoked potentials in cerebral ischemia of rabbits. Acta Neurol Scand 91: 49–53
Wiederholt WC, Iragui-Madoz VJ (1977) Farfield Somatosensory potentials in the rat. Electroencephalogr Clin Neurophysiol 42: 456–465
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wang, Y., Nakashima, K., Shiraishi, Y. et al. The recovery function of paired somatosensory evoked potentials in cerebral ischemic rabbits. Exp Brain Res 106, 233–238 (1995). https://doi.org/10.1007/BF00241118
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00241118