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Transglutaminases

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Summary

This paper is intended as a background to the topic of transglutaminases, while focusing on current ideas regarding the biological roles of these enzymes. Specifically, the following topics are discussed: geometry of forming γ-glutamyl-ε-lysine cross-linked structures; energetic considerations; the γ-glutamyl-ε-lysine cross-link; amine incorporation assays; artefactual incorporation of amines in cells and tissue homogenates; synthetic substrate systems; regulation of transglutaminase activities; strategies for probing transglutaminase-mediated events in biological systems; the blood clotting paradigm; transglutaminase and cell aging: the Ca2+-enriched human erythrocyte; transglutaminase and cell activation: the thrombin-stimulated human platelet and the fertilized sea urchin egg.

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  1. Department of Biochemistry, Molecular and Cell Biology, Northwestern University, 60201, Evanston, IL, USA

    Laszlo Lorand & Sylvia M. Conrad

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Lorand, L., Conrad, S.M. Transglutaminases. Mol Cell Biochem 58, 9–35 (1984). https://doi.org/10.1007/BF00240602

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