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A comparison of the reduction in the K+ activity of the scala media produced by furosemide and ouabain

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Summary

The endocochlear potential (EP) and the K+ activity in the scala media of the guinea pig were recorded by means of K+-sensitive, double-barrelled microelectrodes in the second turn of the cochlea. EP and K+ change were recorded during the perilymphatic perfusion of furosemide and ouabain. Furosemide produced less of a decrease than ouabain in the K− activity relative to the EP decrease. These results suggest that furosemide reduces the EP via different mechanisms from the inhibition of the K+ secretion potential.

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Authors and Affiliations

  1. Department of Otolaryngology, Kagawa Medical School, Kagawa, Japan

    A. Shugyo & N. Mori

  2. Department of Otolaryngology, Osaka University Medical School, Osaka, Japan

    T. Matsunaga

Authors
  1. A. Shugyo
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  2. N. Mori
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  3. T. Matsunaga
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Additional information

Offprint requests to: A. Shugyo, Department of Otolaryngology, Kagawa Medical School, 1750-1 Miki-cho Kita-gun (761-07), Kagawa, Japan

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Shugyo, A., Mori, N. & Matsunaga, T. A comparison of the reduction in the K+ activity of the scala media produced by furosemide and ouabain. Eur Arch Otorhinolaryngol 248, 79–81 (1990). https://doi.org/10.1007/BF00240224

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  • DOI: https://doi.org/10.1007/BF00240224

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