Summary
Progesterone pretreatment of ovariectomised rats resulted in a moderate (44%) lowering of the level of nuclear estradiol receptors found in the uterine epithelium 2 h after a single injection of this estrogen.
References
Anderson, J., Clark, J.H., Peck, E.J.: Oestrogen and nuclear binding sites. Determination of specific sites by [3H] oestradiol exchange. Biochem. J. 126, 561–567 (1972)
Anderson, J.N., Peck, E.J., Clark, J.H.: Estrogen induced uterine responses and growth: relationship to receptor estrogen binding by uterine nuclei. Endocrinology 96, 160–167 (1975)
Bhakoo, H.S., Katzenellenbogen, B.S.: Progesterone antagonism of estradiol-stimulated uterine “induced protein” synthesis. Mol. Cell. Endocrinol. 8, 105–120 (1977a)
Bhakoo, H.S., Katzenellenbogen, B.S.: Progesterone modulation of estrogen-stimulated uterine biosynthetic events and estrogen receptor levels. Mol. Cell. Endocrinol. 8, 121–134 (1977b)
Clark, B.F.: The effects of oestrogen and progesterone on uterine cell division and epithelial morphology in spayed, adrenalectomized rats. J. Endocrinol. 50, 527–528 (1971)
Clark, B.F.: The effect of oestrogen and progesterone on uterine cell division and epithelial morphology in spayed, hypophysectomised rats. J. Endocrinol. 56, 341–342 (1973)
Clark, J.H., Peck, E.J.: Nuclear retention of receptor-oestrogen complex and nuclear acceptor sites. Nature 260, 635–637 (1976)
Gardner, R.M., Kirkland, J.L., Stancel, G.M.: Selective blockade of estrogen-induced uterine responses by the antiestrogen, nafoxidine. Endocrinology 103, 1583–1589 (1978)
Garola, R.E., McGuire, W.L.: Estrogen receptor and proteolytic activity in human breast tumor nuclei. Cancer Res. 37, 3329–3332 (1977)
Hamidi, H., Ph. D. Thesis, University of Strathclyde (1976)
Heald, P.J., Govan, A.D.T., O'Grady, J.E.: A simple method for the preparation of luminal epithelial and stromal cells from rat uterus. J. Reprod. Fertil. 42, 593–595 (1975)
Hsueh, A.J.W., Peck, E.J., Clark, J.H.: Control of uterine estrogen receptor levels by progesterone. Endocrinology 98, 438–444 (1976)
Kelly, P.A.T., Morrison, C., Green, B.: Effect of progesterone treatment on the uptake ofestradiol-17β by uterine tissues of ovariectomised rats. Mol. Cell. Endocrinol. 10, 319–325 (1978)
Lan, N.C., Katzenellenbogen, B.S.: Temporal relationships between hormone receptor binding and biological responses in the uterus: Studies with short-and long-acting derivatives of estriol. Endocrinology 98, 220–227 (1976)
Martin, L., Finn, C.A.: Duration of progesterone treatment required for a stromal response to oestradiol-17β in the uterus of the mouse. J. Endocrinol. 44, 279–280 (1969)
Müller, R.E., Traish, A.M., Wotiz, H.H.: Interaction of receptor-estrogen complex (R.E.) with uterine nuclei. J. Biol. Chem. 252, 8206–8211 (1977)
Scatchard, G.: The attraction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660–672 (1949)
Smith, J.A., Martin, L., King, R.J.B., Vertes, M.: Effects of oestradiol-17β and progesterone on total and nuclear-protein synthesis in epithelial and stromal tissues of the mouse uterus and of progesterone on the ability of these tissues to bind oestradiol-17β. Biochem. J. 119, 773–784 (1970)
Stumpf, W.E.: Localization of hormone binding sites by autoradiography. Acta Histochem. Cytochem. 5, 209–211 (1972)
Stumpf, W.E., Sar, M. (1974) Cited in Prasad, M.R.N., Sar, M., Stumpf, W.E.: Autoradiographic studies on [3H] oestradiol localization in the blastocysts and uterus of rats during delayed implantation. J. Reprod. Fertil. 36, 75–81 (1974)
Tachi, C., Tachi, S., Lindner, H.R.: Modification by progesterone of oestradiol-induced cell proliferation, RNA synthesis and oestradiol distribution in the rat uterus. J. Reprod. Fertil. 31, 59–76 (1972)
Thompson, E.B., Norman, M.R., Lippman, M.E.: Steroid hormone actions in tissue culture cells and cell hybrids-their relation to human malignancies. Recent Prog. Horm. Res. 33, 571–615 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vass, M.A., Green, B. Effect of progesterone pretreatment on the uptake of estradiol-17β by the uterine epithelium of the rat. Cell Tissue Res. 202, 171–175 (1979). https://doi.org/10.1007/BF00239230
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00239230