Summary
Five cats were trained to perform a forelimb ballistic flexion on a reaction time paradigm including an upper limit of about 400 ms for reinforcement (food pellets). They were implanted with a cyrogenic probe thermically insulated, except at the tip, by a vacuum jacket (outer diameter, 1.1 mm).
Four cats had the probe inserted into the ventrolateral thalamic nucleus (VL), contralateral to the moving limb. During cooling they showed increased reaction times, which remained constant throughout daily sessions performed during many weeks, independent of the foreperiod but varying from 25 to 100 ms according to the subject. The temperatures used to upset the reaction times varied from +10 ° C to −8 ° C, depending on the localisation of the probe and on the insulation of the silver tip used to prevent nervous tissue reaction, but for each subject the reaction times always increased when the temperature was lowered. The fifth cat, with a probe inserted between VL and the Centre Median, showed a decrease of reaction times on cooling to 0 ° C and an increase of the reaction times for a cooling at −10 ° C.
For one of the four cats with a probe properly inserted into the VL, strain-gauges were stuck on the lever to measure the latency of the decrease of the pressure exerted by the subject when the subject initiated the forelimb flexion in response to the CS. Reaction times and latencies of pressure changes were closely correlated with the movement onset, and they were equally delayed during cooling. This result demonstrates that it is not by slowing down movement velocity that reaction times are upset during VL cooling but by delaying the movement onset.
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References
Allen, G.I., Tsukahara, N.: Cerebro-cerebellar communication systems. Physiol Rev 54, 957–1006 (1974)
Anderson, M., Yoshida, M.: Electrophysiological evidence for branching nigra projections to the thalamus and the superior colliculus. Brain Res 137. 361–365 (1977)
Asanuma, H., Fernández, J., Scheibel, M.E., Scheibel, A.B.: Characteristics of projections from the nucleus ventralis lateralis to the motor cortex in the cats: an anatomical and physiological study. Exp Brain Res 20, 315–330 (1974)
Bantli, H., Bloedel, J.R.: The action of the dentate nucleus on the excitability of spinal motoneurons via pathways which do not involve the primary sensorimotor cortex. Exp Brain Res 25, 199–220 (1976)
Beaubaton, D., Trouche, E., Amato, G., Grangetto, A.: Dentate cooling in Monkeys performing a visuo-motor pointing task. Neurosci Lett (in press)
Bénita, M.: Nouveau despositif pour le refroidissement localisé des structures nerveuses. Electroenceph Clin Neurophysiol 32, 90–94 (1971)
Bénita, M., Condé, H.: Effects of local cooling upon conduction and synaptic transmission. Brain Res 36, 133–151 (1972a)
Bénita, M., Condé, H.: Reversible blockage of specific synaptic transmission by localized and moderate cooling with a vacuum insulated probe connected to a closed circuit apparatus. Confin Neurol 34, 218–223 (1972b)
Bénita, M., Condé, H., Dormont, J.F., Schmied, A.: Effets du refroidissement du noyau ventral-latéral du thalamus du Chat sur les temps de réaction d'un mouvement de flexion conditionné. J Physiol (Paris) 72, 20A (1976)
Brooks, V.B., Kozlovskaya, I.B., Atkin, A., Horvath, F.E., Uno, M.: Effects of cooling the dentate nucleus on tracking-task performance in Monkeys. J Neurophysiol 36, 974–995 (1973)
Carpenter, M.B., Nakano, K., Kim, R.: Nigrothalamic projections in the monkey demonstrated by autoradiographic technics. J Comp Neurol 165, 401–416 (1976)
Condé, H.; Dormont, J.F., Bénita, M., Schmied, A.: Schedule training of cats to a simple reaction time performance. J Physiol (Paris) (in press)
Davis, F.A.: Axonal conduction studies based on some considerations of temperature effects in multiple sclérosis. Electroenceph Clin Neurophysiol 28, 281–286 (1970)
Ehringer, H., Hornykiewicz, O.: Verteilung von Noradrenalin und Dopamin (3-hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. Klin Wochenschr 38, 1236–1239 (1960)
Evarts, E.V.: Activity of thalamic and cortical neurons in relation to learned movement in the monkey. Int J Neurol 8, 321–326 (1971a)
Evarts, E.V.: Feedback and corollary discharge: a merging of the concepts. In: Central control of movement. Neurosci Res Prog Bull 9, 86–112 (1971b)
Evarts, E.V., Thach, W.T.: Motor mechanisms of the CNS: cerebro-cerebellar interrelations. Ann Rev Physiol 31, 451–498 (1969)
Geddes, L.A.: Electrodes and the measurements of bioelectric events, pp. 129–130. New York: Wiley 1972
Grimm, R.J., Rushmer, D.S.: The activity of dentate neurons during an arm movement sequence. Brain Res 71, 309–326 (1974)
Heilman, K.M., Bowers, D., Watson, R.T., Greer, M.: Reaction times in Parkinson's disease. Arch Neurol 33, 139–140 (1976)
Illert, M., Lundberg, A., Tanaka, R.: Integration in descending motor pathways controlling the forelimb in the cat. 2. Convergence on neurones mediating di-synaptic cortico-motoneuronal excitation. Exp Brain Res 26, 521–540 (1976)
Klee, M.R., Piérau, F.-K., Faber, D.S.: Temperature effects on resting potentials and spike parameters of cat motoneurons. Exp Brain Res 19, 478–492 (1974)
Kornhuber, H.H.: Motor functions of cerebellum and basal ganglia: the cerebellocortical saccadic (ballistic) clock, the cerebellonuclear hold regulator, and the basal ganglia ramp (voluntary speed smooth movement) generator. Kybernetic 8, 157–172 (1971)
Laursen, A.M., Wiesendanger, M.: The effect of pyramidal lesions on response latency in cats. Brain Res 5, 207–220 (1967)
Massion, J., Angaut, P., Albe-Fessard, D.: Activity evoked in the cat in the region of the nucleus ventralis lateralis by various sensory stimuli: I. Macro-physiological study. Electroenceph Clin Neurophysiol 19, 433–451 (1965)
Meyer-Lohman, J., Hore, J., Brooks, V.B.: Cerebellar participation in generation of prompt arm movement. J Neurophysiol 40, 1938–1050 (1977)
Mountcastle, V.B., Lynch, J.C., Georgopoulos, A., Sakata, H., Acuna, C.: Posterior parietal association cortex of the monkey: command function for operations within extrapersonal space. J Neurophysiol 38, 871–908 (1975)
Nysenbaum-Requin, S., Tardy, M.F., Vitton, N.: Incertitude temporelle, probabilité conditionnelle du signal de résponse et apprentissage d'une tache de temps de réaction simple chez le chat. Can J Psychol 26, 348–360 (1972)
Paintal, A.S.: Block of conduction in mammalian nerve fibres by low temperatures. J Physiol (Lond) 180, 1–19 (1965)
Poirier, L.J., Sourkes, T.L.: Influence of the substantia nigra on the catecholamine content of the striatum. Brain 88, 181–192 (1965)
Rinvik, E.: Demonstration of nigrothalamic connections in the cat by retrograde axonal transport of horseradish peroxidase. Brain Res 90, 313–319 (1975)
Rispal-Padel, L., Massion, J., Grangetto, A.: Relations between the ventrolateral thalamic nucleus and motor cortex and their possible role in the central organization of motor control. Brain Res 60, 1–20 (1973)
Rispal-Padel, L., Grangetto, A.: The cerebello-thalamo-cortical pathway. Topographical investigation at the unitary level in the cat. Exp Brain Res 28, 101–123 (1977)
Schmied, A., Bénita, M., Condé, H., Dormont, J.F.: Corrélations entre l'activité des cellules du noyau ventrolateral et les temps de réaction chez le chat conditionné. J. Physiol (Paris) 69, 296A-297A (1974)
Strick, P.L.: Activity of ventrolateral thalamic neurons during arm movement. J Neurophysiol 39, 1032–1044 (1976)
Teuber, H.L.: Key problems in the programming of movements. (Panel discussion) Brain Res 71, 533–568 (1974)
Thach, W.T.: Discharge of cerebellar neurones related to two maintained postures and two prompt movements. I. Nuclear cell output. J Neurophysiol 33, 527–536 (1970)
Thach, W.T.: Cerebellar output: properties, synthesis and uses. Brain Res 40, 89–97 (1972)
Thach, W.T.: Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movement. Brain Res 88, 233–241 (1975)
Ueki, A., Uno, M.,Yoshida, M.: Monosynaptic inhibition of thalamic neurons by stimulation of the substantia nigra. Proceed. Int. Union Physiol. Sci. 13, Paris, Abstr. 2291 (1977)
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Bénita, M., Condé, H., Dormont, J.F. et al. Effects of ventrolateral thalamic nucleus cooling on initiation of forelimb ballistic flexion movements by conditioned cats. Exp Brain Res 34, 435–452 (1979). https://doi.org/10.1007/BF00239141
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DOI: https://doi.org/10.1007/BF00239141