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Tyrosine hydroxylation in the rat striatum after fentanyl and droperidol in vivo

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Summary

The effects of fentanyl, droperidol, and morphine on tyrosine hydroxylation in the rat striatum was measured after inhibition of aromatic amino acid decarboxylase with R04-4602.

Any direct change in the product of hydroxylation (i.e.dopa) was supposed to reflect a change in enzyme activity.

Fentanyl (0.1 mg/kg intraperitoneally) first (10 min) appears to slightly depress, and later (30 min) significantly activate tyrosine hydroxylation.

Morphine (10 mg/kg i.p.) activates tyrosine hydroxylation to a much lesser degree than fentanyl.

Droperidol (3 mg/kg i.p.) only slightly activates the in vivo activity of the enzyme.

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  1. E. Freye

    Present address: Medizinische Einrichtungen der Universität, Abteilung Experimentelle Anästhesiologie, Moorenstraße 5, 4000, Düsseldorf l, Federal Republic of Germany

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  1. Dept. of Biochemical Pharmacology, Max-Planck-Institute for Experimental Medicine, D-3400, Göttingen, Federal Republic of Germany

    E. Freye

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Freye, E. Tyrosine hydroxylation in the rat striatum after fentanyl and droperidol in vivo. Exp Brain Res 26, 541–545 (1976). https://doi.org/10.1007/BF00238826

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  • DOI: https://doi.org/10.1007/BF00238826

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