Abstract
Cardiac transplant patients manifest several haemodynamic changes as well as altered peripheral responses to exercise which may disrupt body fluid regulation. This study examined the effect on an endurance training programme on the exercise-induced hydromineral endocrine responses of heart transplant patients. Seven patients underwent a square-wave exercise test before and after a 6-week training programme. The tests were performed at the same absolute intensity but, during training, the workload was increased to maintain the same relative exercise intensity. Pretraining results were compared to those obtained from agematched controls. Training improved physical capacity, producing a significant increase in maximal tolerated power and workload between the first and last training session (P < 0.05, P < 0.001, respectively). Haematocrit and osmolality were increased in both groups at the end of exercise (P < 0.01) but changes observed post-training did not differ from pretraining values. Apart from atrial natriuretic peptide (ANP), which showed significantly higher concentrations at rest and during exercise (P < 0.01), the changes in hydromineral hormones of the patients resembled those of the controls. Basal plasma renin activity (PRA) was slightly raised prior to training (P < 0.07) compared to the controls and post-training. For both PRA and aldosterone, a significant training effect was revealed when both the exercise-stimulated increase and postexercise decline were considered (P < 0.05), possibly reflecting lower noradrenaline concentrations. Training had no effect on either basal or exercise stimulated ANP levels, which is compatible with the theory that ANP regulation is largely under mechanical rather than sympathetic nervous system control. Mean arginine vasopressin concentrations in the patients were not increased, possibly due to inhibitory effects of immunosuppressive glucocorticoids combined with the large variation in response observed, particularly for the untrained patients. In summary, these results showed that despite cardiac denervation, the heart transplant patients demonstrated effective body fluid regulatory endocrine responses during exercise and that although training produced substantial improvement in their physical capacity, it was accompanied by only subtle changes in hydromineral hormones.
Similar content being viewed by others
References
Braith RW, Wood CE, Limacher MC, Pollock ML, Lowenthal DT, Phillips MI, Staples ED (1992) Abnormal neuroendocrine responses during exercise in heart transplant recipients. Circulation 86:1453–1463
Convertino VA, Thompson CA, Benjamin BA, Keil LC, Savin WM, Gordon EP, Haskell WL, Schroeder JS, Sandler H (1990) Haemodynamic and ADH responses to central blood volume shifts in cardiac-denervated humans. Clin Physiol 10:55–67
Drieu L, Rainfray M, Cabrol C, Ardaillou R (1986) Vasopressin, aldosterone and renin responses to volume depletion in hearttransplant recipients. Clin Sci 70:233–241
Fagard R, Grauwels R, Groeseneken D, Lijner P, Staesser J, Vanhess L, Amery A (1985) Plasma levels of renin, angiotensin-II and 6-keto-prostaglandin F12 in endurance athletes. J Appl Physiol 59:947–952
Follenius M, Brandenberger G (1988) Increase in atrial natriuretic peptide in response to physical exercise. Eur J Appl Physiol 57:159–162
Geyssant A, Geelen G, Denis C, Allevard AM, Vincent M, Jarsaillon E, Bizollon CA, Lacour JR, Gharib C (1981) Plasma vasopressin, renin activity and aldosterone: effect of exercise and training. Eur J Appl Physiol 46:21–30
Gimenez M, Servera E, Salinas W (1982) Square-Wave-EnduranceTest (SWEET) for training and assessment in trained and untrained subjects. Eur J Appl Physiol 49:359–387
Hespel P, Lijnen P, VanHoff R, Fagard R, Goossens W, Lissens W, Moerman E, Amery A (1988) Effects of physical endurance training on the plasma renin-angiotensin-aldosterone system in normal man. J Endocrinol 116:443–449
Howlett TA (1987) Hormonal responses to exercise and training: a short review. Clin Endocrinol 26:723–742
Lonsdorfer J, Lampert E, Mettauer B, Hoppeler H, Frey M, Schnedecker B, Dah C, Epailly E (1992) Physical fitness after cardiac transplantation: a proposal for an endurance training program and its assessment. Sci Sports 7:39–44
Mettauer B, Lampert E, Schnedecker B, Frey M, Geny B, Eisenman B, Hoppeler H, Lonsdorfer J (1993) A short endurance training program increases the physical fitness of heart transplant recipients. Sci Sports 8:25–26
Meyer M, Cerretelli P, Marconi C, Rieu M, Cabrol CH (1989) Cardiorespiratory adjustment to exercise after cardiac transplantation. In: Reinhartk, Eyrichk (eds) Clinical aspects of O2 transport and tissue oxygenation Springer, Berlin Heidelberg New York, p 477–499
Niset G, Hermans L, Depelchin P (1991) Exercise and heart transplantation. A review. Sports Med 12:359–379
Péronnet F, Cléroux J, Perrault H, Cousineau D, De Champlain J, Nadeau R (1981) Plasma norephinephrine response to exercise before and after training in humans. J Appl Physiol 51:812–815
Perrault H, Melin B, Jimenez C, Dureau G, Dureau P, Allevard AM, Cottet-Emard JM, Gauquelin G, Gharib C (1994) Fluid-regulating and sympathoadrenal hormone responses to peak exercise following cardiac transplantation. J Appl Physiol 76:230–235
Peterson TV, Jones CE (1983) Renal responses of the cardiac-denervated nonhuman primate to blood volume expansion. Circ Res 53:24–32
Pope SE, Stinson EB, Daughters GT, Schroeder JS, Ingels NB, Alderman EL (1980) Exercise response of the denervated heart in long-term cardiac transplant recipients. Am J Cardiol 46:213–218
Raff H (1987) Glucocorticoid inhibition of neurohypophysial vasopressin secretion. Am J Physiol 252:R635-R644
Richards AM, Tonolo G, Cleland JGF, McIntyre GD, Leckie BJ, Dargie HJ, Ball SG, Robertson JIS (1987) Plasma atrial natriuretic peptide concentrations during exercise in sodium replete and deplete normal men. Clin Sci 72:159–164
Savin WM, Haskell WL, Schroeder JS, Stinson EB (1980) Cardiorespiratory responses of cardiac transplant patients to graded, symptom-limited exercise. Circulation 62:55–60
Schüler S, Thomas D, Thebken M, Frei U, Wagner T, Warnecke H, Hetzer R (1987) Endocrine response to exercise in cardiac transplant patients. Transplant Proc 19:2506–2509
Singer DRJ, Banner NR, Cox A, Patel N, Burdon M, Buckley MG, MacGregor GA, Yacoub MH (1990) Response to dynamic exercise in cardiac transplant recipients: implications for control of the sodium regulatory hormone, atrial natriuretic peptide. Clin Sci 78:159–163
Sinoway LI, Minotti JR, Davis D, Pennock JL, Burg JE, Musch TI, Zelis R (1988) Delayed reversal of impaired vasodilation in congestive heart failure after heart transplantation. Am J Cardiol 61:1076–1079
Skipka W, Boning D, Deck KA, Külpmann WR, Meurer KA (1979) Reduced aldosterone and sodium excretion in endurance-trained athletes before and during immersion. Eur J Appl Physiol 42:255–261
Squires RW (1991) Exercise training after cardiac transplantation. Med Sports Exerc 23:686–694
Tanaka H, Shindo M, Gutowska J, Kinoshita A, Urata H, Ikeda M, Arakawa K (1986) Effects of acute exercise on plasma immunoreactive atrial natriuretic factor. Life Sci 39:1685–1693
Walsh KP, Williams TDM, Spiteri C, Pitts E, Lightman SL, Sutton R (1988) Role of atrial pressure and rate in release of atrial natriuretic peptide. Am J Physiol 254:R607-R610.
Wong NLM, Wong EFC, Au GH, Hu DCK (1988) Effect of alpha and beta adrenergic stimulation on atrial natriuretic peptide release in vitro. Am J Physiol 255:E260-E264
Yusuf S, Theodoropoulos S, Mathias CJ, Dhalla N, Wittes J, Mitchell A, Yacoub M (1987) Increased sensitivity of the denervated transplanted human heart to isoprenaline both before and after beta-adrenergic blockage. Circulation 75:696–704
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saini, J., Brandenberger, G., Wittersheim, G. et al. Training effects on the hydromineral endocrine responses of cardiac transplant patients. Eur J Appl Physiol 70, 226–233 (1995). https://doi.org/10.1007/BF00238568
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00238568