Summary
In alert Rhesus monkeys (Macaca mulatta) neuronal activity of vestibular nuclei was recorded during pure vestibular and conflicting visual-vestibular stimulation. Pure vestibular stimulation consisted of rotating the monkey about the vertical axis in complete darkness. During conflicting visual-vestibular stimulation the monkeys were rotated in the light within a vertically striped cylinder mechanically coupled to the turntable. The conflict is that although the monkey is accelerated, there is no relative movement between visual surrounding and the animal. In the conflict situation thresholds of neuronal modulation and of nystagmus were raised compared with those during pure vestibular stimulation. Nystagmus slow-phase velocity could always be dissociated from the neuronal activity, the nystagmus often being totally suppressed whereas the neuronal activity was only attenuated. This suggests a further information processing between vestibular and oculomotor nuclei in the generation of nystagmus.
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References
Allum, J.H.J., Graf, W., Dichgans, J., Schmidt, C.L.: Visual-vestibular interactions in the vestibular nuclei of the goldfish. Exp Brain Res 26, 463–485 (1976)
Angaut, P., Brodal, A.: The projection of the “vestibulo-cerebellum” onto the vestibular nuclei in the cat. Arch Ital Biol 105, 441–479 (1967)
Azzena, G.B., Azzena, M.T., Marini, R.: Optokinetic nystagmus and the vestibular nuclei. Exp Neurol 42, 158–168 (1974)
Azzena, G.B., Mameli, O., Tolu, E.: Relationships of the optic pathways to the vestibular nuclei. Proc Int Un Physiol Sci 13, 40 (1977)
Baarsma, E.A., Collewijn, H.: Vestibular-ocular and optokinetic reactions to rotation and their interaction in the rabbit. J Physiol (Lond) 238, 603–625 (1974)
Cohen, B., Matsuo, V., Raphan, Th.: Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after-nystagmus. J Physiol (Lond) 270, 321–344 (1977)
Dichgans, J., Brandt, Th.: Visual-vestibular interaction and motion perception. In: Cerebral control of eye movements and motion perception (eds. J. Dichgans and E. Bizzi). Bibl Ophthal 82, 327–338 (1972)
Dichgans, J., Schmidt, C.L., Graf, W.: Visual input improves the speedometer function of the vestibular nuclei in the goldfish. Exp Brain Res 18, 319–322 (1973)
Duensing, F., Schaefer, K.P.: Die Aktivität einzelner Neurone im Bereich der Vestibulariskerne bei Horizontalbeschleunigungen unter besonderer Berücksichtigung des vestibulären Nystagmus. Arch Psychiat Nervenkr 198, 224–252 (1958)
Fuchs, A.F., Kimm, J.: Unit activity in vestibular nucleus of the alert monkey during horizontal angular accelerations and eye movements. J Neurophysiol 38, 1140–1161 (1975)
Fukuda, J., Highstein, S.M., Ito, M.: Cerebellar inhibitory control of the vestibulo-ocular reflex investigated in rabbit IIIrd nucleus. Exp Brain Res 14, 511–526 (1972)
Goldberg, J.M., Fernández, C.: Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. I. Resting discharge and response to constant angular accelerations. J Neurophysiol 34, 635–660 (1971)
Henn, V., Young, L.R., Finley, C.: Vestibular nucleus units in alert monkeys are also influenced by moving visual fields. Brain Res 71, 144–149 (1974)
Ito, M., Nisimaru, N., Yamamoto, M.: Specific neural connections for the cerebellar control of vestibulo-ocular reflexes. Brain Res 60, 238–243 (1973)
Keller, E.L., Daniels, P.D.: Oculomotor related interaction of vestibular and visual stimulation in vestibular nucleus cells in alert monkey. Exp Neurol 46, 187–198 (1975)
Keller, E.L., Kamath, B.Y.: Characteristics of head rotation and eye movement-related neurons in alert monkey vestibular nucleus. Brain Res 100, 182–187 (1975)
Kubo, T., Matsunaga, T., Yamamoto, K.: Response of brainstem units to visual and vestibular stimuli in the rabbit. Proc. Bárány Soc. 6th Meet., London: Academic Press (in press) (1978)
Lisberger, S.G., Fuchs, A.F.: Response of flocculus Purkinje cells to adequate vestibular stimulation in the alert monkey: fixation vs. compensatory eye movements. Brain Res 69, 347–353 (1974)
Lorente de Nó, R.: Vestibulo-ocular reflex arc. Arch Neurol Psychol 30, 245–291 (1933)
Maekawa, K., Simpson, J.I.: Climbing fiber responses evoked in vestibulocerebellum of rabbit from visual system. J Neurophysiol 36, 649–666 (1973)
Maekawa, K., Natsui, T.: Climbing fiber activation of Purkinje cells in rabbits' flocculus during light stimulation of the retina. Brain Res 59, 417–420 (1973)
Markham, Ch.H., Precht, W., Shimazu, H.: Effect of stimulation of interstitial nucleus of Cajal on vestibular unit activity in the cat. J Neurophysiol 29, 493–507 (1966)
Miles, F.A.: Single unit firing patterns in the vestibular nuclei related to voluntary eye movements and passive body rotation in conscious monkeys. Brain Res 71, 215–224 (1974)
Miles, T.S., Henn, V.S.: Time constants of secondary vestibular neurons recorded from alert monkeys. Pfluegers Arch Suppl 362, R 49 (1976)
Pompeiano, O., Walberg, F.: Descending connections to the vestibular nuclei. An experimental study in the cat. J Comp Neurol 108, 465–503 (1957)
Raphan, T., Cohen, B., Matsuo, V.: A velocity storage mechanism responsible for optokinetic nystagmus (OKN), optokinetic after-nystagmus (OKAN) and vestibular nystagmus. In: Control of gaze by brain stem neurons (eds. R. Baker and A. Berthoz), p. 37–47. Amsterdam: Elsevier 1977
Robinson, D.A.: Linear addition of optokinetic and vestibular signals in the vestibular nucleus. Exp Brain Res 30, 447–450 (1977a)
Robinson, D.A.: Vestibular and optokinetic symbiosis: an example of explaining by modelling. In: Control of gaze by brain stem neurons (eds. R. Baker and A. Berthoz), p. 49–58. Amsterdam: Elsevier 1977b
Shimazu, H., Precht, W.J.: Tonic and kinetic responses of cats vestibular neurons to horizontal angular acceleration. J Neurophysiol 28, 991–1013 (1965)
Takemori, S., Cohen, B.: Loss of visual suppression of vestibular nystagmus after flocculus lesions. Brain Res 72, 213–224 (1974)
Waespe, W., Henn, V.: Thresholds for optokinetic and vestibular stimulation in neurons of the vestibular nuclei of alert monkeys. Pflügers Arch Suppl 386, R 45 (1977a)
Waespe, W., Henn, V.: Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation. Exp Brain Res 27, 523–538 (1977b)
Waespe, W., Henn, V.: Vestibular nuclei activity during optokinetic after-nystagmus (OKAN) in the alert monkey. Exp Brain Res 30, 323–330 (1977c)
Waespe, W., Henn, V., Miles, T.S.: Activity in the vestibular nuclei of the alert monkey during spontaneous eye movements and vestibular or optokinetic stimulation. In: Control of gaze by brain stem neurons (eds. R. Baker and A. Berthoz), p. 269–278. Amsterdam: Elsevier 1977
Young, L.R.: On visual vestibular interaction. NASA 5th Symp. on the role of the vestibular organs in space exploration. NASA-SP-314, 205–210 (1970)
Zacharias, G.L., Young, L. R.: Manual control of yaw motion with combined visual and vestibular cues. IEEE Trans. Systems, Man and Cybernetics (in press)
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Supported in part by Swiss National Foundation for Scientific Research 3.672-0.77, and Emil Barell-Foundation of Hoffmann-La Roche, Basel, Switzerland
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Waespe, W., Henn, V. Conflicting visual-vestibular stimulation and vestibular nucleus activity in alert monkeys. Exp Brain Res 33, 203–211 (1978). https://doi.org/10.1007/BF00238060
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DOI: https://doi.org/10.1007/BF00238060