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Association of Thy-1 cell surface differentiation antigen with certain connective tissues in vivo

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Summary

The cell surface differentiation antigen, Thy-1, has been demonstrated by immunofluorescence to be associated with some collagen-based connective tissue. In the rat, the basement membrane of kidney collecting tubules and of certain blood vessels, reticulin of the lamina propria, loose connective tissue in the dermis, and collagen fibres within certain nerve cell tumours, bear the antigen. Other, apparently similar, connective tissue (especially that of muscle and liver) lacked Thy-1. In the mouse, only the connective tissue of the skin was found to bear the antigen. The possible origin of this extracellular Thy-1, and its implications for the function of the molecule, are discussed.

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Authors and Affiliations

  1. Laboratory of Neurobiology, National Institute for Medical Research, The Ridgeway, NW7 1AA, Mill Hill, London, England

    Roger J. Morris & Mary A. Ritter

  2. Microbiology Department, University of Connecticut Health Center, Farmington, Ct., USA

    Roger J. Morris & Mary A. Ritter

  3. Membrane Immunology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England

    Roger J. Morris & Mary A. Ritter

Authors
  1. Roger J. Morris
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  2. Mary A. Ritter
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Additional information

Part of this work was supported by grant no. NS10861 from the National Institute of Health and no. BNS 77-15818 from the National Science Foundation, awarded to Dr. S.E. Pfeiffer

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Morris, R.J., Ritter, M.A. Association of Thy-1 cell surface differentiation antigen with certain connective tissues in vivo. Cell Tissue Res. 206, 459–475 (1980). https://doi.org/10.1007/BF00237975

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