Summary
Microinjections of horseradish peroxidase (HRP) were made in different sublobules of the uvula (lobule IX, a, b, and c of Larsell, 1952) of the cerebellar cortex in the rat. These injections resulted in retrograde labeling of cells located in the pontine nuclei. Sublobule IXa receives a predominant input from a single column of cells situated in a dorsointermediate position in the caudal pontine nuclei. Sublobules IXb and IXc receive a pontine projection from two different columns of cells, one medial and one lateral. The location of the labeled cells in the lateral part of the caudal pons suggests a topographic projection to the subdivisions of the uvula. Sublobule IXa receives a projection from a distinct dorsointermediate region and sublobule IXb and IXc receive a projection from partially overlapping ventral regions. The cells of origin in the medial pons are organized such that more dorsally located cells project to sublobule IXc and ventrally located cells project to sublobule IXb with extensive overlap. These differential patterns of projections to the sublobules of the uvula along with other data in the literature suggest that sublobule IXa may be involved with different functional correlates than sublobules IXb and IXc.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brodal, A.: The olivocerebellar projection in the cat as studied with the method of retrograde axonal transport of horseradish peroxidase. II. The projection to the uvula. J. Comp. Neurol. 166, 417–426 (1977).
Brodal, A., Drabløs, P.A.: Two types of mossy fiber terminals in the cerebellum and their regional distribution. J. Comp. Neurol. 121, 173–187 (1963).
Brodal, A., Høivik, B.: Site and mode of termination of primary vestibulo-cerebellar fibres in the cat. Arch. Ital. Biol. 102, 1–21 (1964).
Brodal, P.: The cortico-pontine projection in the cat. I. Demonstration of a somatotopically organized projection from the primary sensorimotor cortex. Exp. Brain Res. 5, 210–234 (1968).
Brodal, P.: The cortico-pontine projection in the cat. I. The projection from the proreate gyrus. J. Comp. Neurol. 142, 127–140 (1971).
Burne, R.A., Eriksson, M.A., Saint-Cyr, J.A., Woodward, D.J.: The organization of the pontine projection to lateral cerebellar areas in the rat: dual zones in the pons. Brain Res. 139, 340–347 (1978).
Carpenter, M.B., Stein, B.M., Peter, P.: Primary vestibulo-cerebellar fibers in the monkey: distribution of fibers arising from distinctive cell groups of the vestibular ganglia. Am. J. Anat. 135, 221–250 (1972).
Dow, R.S.: The fiber connections of the posterior parts of the cerebellum in the cat and rat. J. Comp. Neurol. 63, 527–548 (1936).
Ebbesson, S.O.E., Rubinson, K.: Macrophotography of histological sections. Physiol. Behav. 7, 261–262 (1971).
Eisenman, L.M.: The ponto-cerebellar projection in the rat: Differential projection to subdivisions of the uvula. Soc. Neurosci. Abstr. 4, 65 (1978).
Graybiel, A.M.: Visuo-cerebellar and cerebello-visual connections involving the ventral lateral geniculate nucleus. Exp. Brain Res. 20, 303–306 (1974).
Hochstetter, F.: Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns. Wien, Leipzig: Denticke 1929.
Joseph, J.W., Shambes, G.M., Gibson, J.M., Welker, W.: Tactile projections to granule cells in caudal vermis of the rats' cerebellum. Brain Behav. Evol. 15, 141–149 (1978).
Korneliussen, H.K.: On the ontogenetic development of the cerebellum (nuclei, fissures, and cortex) of the rat, with special reference to regional variations in corticogenesis. J. Hirnforsch. 10, 379–413 (1968).
Korneliussen, H.K.: Histogenesis of the cerebellar cortex and cortical zones. In: The comparative anatomy and histology of the cerebellum. The human cerebellum, cerebellar connections and cerebellar cortex, Larsell, O., Jansen, J. (eds.), pp. 164–178. Minneapolis: University of Minnesota Press 1972.
Larsell, O.: The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J. Comp. Neurol. 97, 281–356 (1952).
Mesulam, M.M.: The blue reaction product in horseradish peroxidase neurohistochemistry: Incubation parameters and visibility. J. Histochem. Cytochem. 24, 1273–1280 (1976).
Mihailoff, G.A., Burne, R.A., Woodward, D.J.: Projections of the sensorimotor cortex to the basilar pontine nuclei in the rat: an autoradiographic study. Brain Res. 145, 347–354 (1978).
Shambes, G.M., Gibson, J.M., Welker, W.: Fractured somatotopy in granule cell tactile areas of the rat cerebellar hemispheres revealed by micromapping. Brain Behav. Evol. 15, 1273–1280 (1976).
Wise, S.P., Jones, E.G.: Cells of origin and terminal distribution of descending projections of the rat somatic serisory cortex. J. Comp. Neurol. 175, 129–158 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eisenman, L.M., Noback, C.R. The ponto-cerebellar projection in the rat: Differential projections to sublobules of the uvula. Exp Brain Res 38, 11–17 (1980). https://doi.org/10.1007/BF00237925
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00237925