Summary
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1.
The spatial organization of the cerebello-thalamo-cortical relations has been studied in semi-chronic cats. VL neurons were recorded during stimulation of two cerebellar nuclei, the nucleus interpositus posterior (NIP) and the dentate nucleus (ND).
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2.
Latency histograms of thalamic responses induced from the stimulation of each of two cerebellar nuclei are comparable and suggest that the cerebello-thalamic fibres have similar calibers whether they originate in the NIP or ND.
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3.
The anatomical localisation of recording sites indicates that the short latency (less than 1.5 msec) thalamic responses (transmitted by a monosynaptic pathway) are confined to a restricted VL region while the long latency responses are dispersed throughout the nucleus. The monosynaptic responses induced by NIP stimulation are localized in the ventrolateral part of the VL. This VL region is connected to the motor cortical area controlling the forelimb. The ND sends projections into a more medial and dorsal region which is principally connected to the motor area controlling the axial musculature and the shoulder.
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4.
In some cases it has been observed that the same thalamic cell can be excited from both cerebellar nuclei. The fact that thalamic neurones are not tied specifically to a given afferent pathway is discussed.
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The cerebellothalamic well as the thalamocortical relations have a divergent pattern. The efferents from each cerebellar site can excite a large number of VL neurons which can be sometimes several millimeters apart.
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6.
Cerebellar projections on small cortical foci have also been found. The functional interpretation of these two characteristics of the pathway is discussed.
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References
Andersen, P., Hagan, P.J., Phillips, C.G., Powell, T.P.S.: Mapping by microstimulation of overlapping projections from area 4 to motor units of the baboon's hand. Proc. roy. Soc. B 188, 31–60 (1974)
Angaut, P.: Etude anatomique expérimentale des efférences cérébelleuses ascendantes. Thèse de Doctorat ès Sciences, Faculté des Sciences de Paris, 186 p. (1969)
Angaut, P.: The ascending projections of the nucleus interpositus posterior of the cat cerebellum: an experimental anatomical study using silver impregnation methods. Brain Res. 24, 377–394 (1970)
Angaut, P.: Bases anatomo-fonctionelles des interrelations cérébello-cérébrales. J. Physiol. (Paris) 67, 53A-116A (1973)
Angaut, P., Bowsher, D.: Ascending projections of the medial cerebellar (Fastigial) nucleus: an experimental study in the cat. Brain Res. 24, 49–68 (1970)
Angaut, P., Guilbaud, G., Reymond, M.C.: An electrophysiological study of the cerebellar projections to the nucleus ventralis lateralis of thalamus in the cat. I. Nuclei fastigii and interpositus. J. comp. Neurol. 134, 9–20 (1968)
Appelberg, B.: Localization of focal potentials evoked in the red nucleus and the ventrolateral nucleus of the thalamus by electrical stimulation of the cerebellar nuclei. Acta physiol. scand. 51, 356–370 (1961)
Asanuma, H., Fernandez, J., Scheibel, M.E., Scheibel, A.B.: Characteristics of projections from the nucleus ventralis lateralis to the motor cortex in the cats: an anatomical and physiological study. Exp. Brain Res. 20, 315–331 (1974)
Asanuma, H., Hunsperger, R.W.: Functional significance of projection from the cerebellar nuclei to the motor cortex in the cat. Brain Res. 98, 57–73 (1975)
Asanuma, H., Sakata, H.: Functional organization of a cortical efferent system examined with focal depth stimulation in cats. J. Neurophysiol. 30, 35–54 (1967)
Bernent, S.L., Ranck, J.B.: A quantitative study of electrical stimulation of central myelinated fibers. Exp. Neurol. 24, 147–170 (1969)
Brock, L.G., Coombs, J.S., Eccles, J.C.: The recording of potentials from motoneurones with an intracellular electrode. J. Physiol. (Lond.) 117, 431–460 (1952)
Chambers, W.W., Sprague, J.M.: Functional localization in the cerebellum. II. Somatotopic organization in cortex and nuclei. Arch. Neurol. Psychiat. (Chic.) 74, 653–680 (1955)
Condé, H., Angaut, P.: An electrophysiological study of the cerebellar projections to the ventralis lateralis thalami in the cat. II. Nucleus lateralis. Brain Res. 20, 107–119 (1970)
Coombs, J.S., Curtis, D.R., Eccles, J.C.: The interpretation of spike potentials of motoneurones. J. Physiol. (Lond.) 139, 198–231 (1957)
Desiraju, T., Purpura, D.P.: Synaptic convergence of cerebellar and lenticular projections to thalamus. Brain Res. 15, 544–547 (1969)
Dormont, J.F., Ohye, C.: Entopedoncular projection to the thalamic ventrolateral nucleus of the cat. Exp. Brain Res. 12, 254–264 (1971)
Dormont, J.F., Ohye, C., Albe-Fessard, D.: Comparison of the relationships of the nucleus entopedoncularis and brachium conjunctivum with the thalamic nucleus ventralis lateralis of the cat. Parkinson's Dis. 38, 108–111 (1969)
Filion, M., Lamarre, Y., Cordeau, J.P.: Neuronal discharges of the ventrolateral nucleus of the thalamus during sleep and wakefulness in the cat. II. Evoked activity. Exp. Brain Res. 12, 499–508 (1971)
Flood, S., Jansen, J.: On the cerebellar nuclei of the cat. Acta anat. (Basel) 46, 52–72 (1961)
Frigyesi, T.L., Schwartz, R.: Cortical control of thalamic sensorimotor relay activities in the cat and squirrel monkey. In: Corticothalamic projections and sensorimotor activities (eds. T.L. Frigyesi, E. Rinvik, M.D. Yahr), pp. 161–190. New York: Raven Press 1972
Grofová, I., Rinvik, E.: Light and electron microscopical studies of the normal structure and main afferent connections to the nuclei ventralis lateralis and ventralis anterior thalami of the cat. Confin. neurol. (Basel) 36, 256–272 (1974a)
Grofová, I., Rinvik, E.: Cortical and pallidal projections to the nucleus ventralis lateralis thalami; electron microscopical studies in the cat. Anat. Embryol. 146, 113–132 (1974b)
Jankowska, E., Padel, Y., Tanaka, R.: The mode of activation of pyramidal cells by intracortical stimuli. J. Physiol. (Lond.) 249, 617–636 (1975a)
Jankowska, E., Padel, Y., Tanaka, R.: Projections of pyramidal tract cells to alpha motoneurones innervating hindlimb muscles in the monkey. J. Physiol. (Lond.) 249, 637–667 (1975b)
Jankowska, E., Smith, P.O.: Antidromic activation of Renshaw cells and their axonal projections. Acta physiol. scand. 88, 198–214 (1973)
Jasper, H.H., Ajmone-Marsan, G.: A stereotaxic atlas of the diencephalon of the cat. The National Research Council of Canada, Ottawa, Canada (1954)
Kiss, A., Tömböl, T.: Golgi analysis and degeneration studies of the nucleus ventralis lateralis and ventralis medialis in the cat thalamus. Brain Res. 47, 303–315 (1972)
Lamarre, Y., Filion, M., Cordeau, J.P.: Neuronal discharges of the ventrolateral nucleus of the thalamus during sleep and wakefulness in the cat. I. Spontaneous activity. Exp. Brain Res. 3, 480–498 (1971)
Marshall, K.C., MacLennan, H.: The synaptic activation of neurones of the feline ventrolateral thalamic nucleus: possible cholinergic mechanisms. Exp. Brain Res. 15, 472–483 (1972)
Massion, J.: Etude d'une structure motrice thalamique, le noyau ventrolateral, et de sa régulation par les afférences sensorielles. Thèse de Doctorat ès Sciences. Université de Paris 134 p. (1968)
Massion, J.: Intervention des voies cérébello-corticales et cortico-cérébelleuses dans l'organisation et la régulation du mouvement. J. Physiol. (Paris) 67, 117A-170A (1973)
Massion, J., Rispal-Padel, L.: Differential control of motor cortex and sensory areas on ventrolateral nucleus of the thalamus. In: Corticothalamic projections and sensorimotor activities (eds. T.L. Frigyesi, E. Rinvik, M.D. Yahr), pp. 357–374. New York: Raven Press 1972
Nakamura, Y., Schlag, J.: Cortically induced rhythmic activities in the thalamic ventrolateral nucleus of the cat. Exp. Neurol. 22, 210–220 (1968)
Nieoullon, A.: La commande motrice et les relations cérébro-cérébelleuses chez le Chat. Thèse de Doctorat de 3è Cycle. Université d'Aix-Marseille III. 72 p. (1974)
Nieoullon, A., Rispal-Padel, L.: Somatotopic localizations in cat motor cortex. Brain Res. 105, 405–422 (1976)
Ohye, C., Dormont, J.F.: Etude électrophysiologique des projections du noyau entopédonculaire vers le noyau ventrolatéral du thalamus. J. Physiol. (Paris) 60, 281–282 (1968)
Rinvik, E.: A re-evaluation of the cytoarchitecture of the ventral nuclear complex of the cat's thalamus on the basis of corticothalamic connections. Brain Res. 8, 237–254 (1968)
Rinvik, E., Grofová, I.: Light and electron microscopical studies of the normal nuclei ventralis lateralis and ventralis anterior thalami in the cat. Anat. Embryol. 146, 57–93 (1974a)
Rinvik, E., Grofová, I.: Cerebellar projections to the nuclei ventralis lateralis and ventralis anterior thalami. Experimental electron microscopical and light microscopical studies in the cat. Anat. Embryol. 146, 95–111 (1974b)
Rispal-Padel, L., Grangetto, A.: Relations entre les aires corticales (motrices 4 et 6; associatives 5 et 7) et le noyau ventrolatéral du thalamus. Etude au niveau unitaire. En préparation
Rispal-Padel, L., Latreille, J.: The organization of projections from the cerebellar nuclei to the contralateral motor cortex in the cat. Exp. Brain Res. 19, 36–60 (1974)
Rispal-Padel, L., Massion, J.: Relations between the ventrolateral nucleus and the motor cortex in the cat. Exp. Brain Res. 10, 331–339 (1970)
Rispal-Padel, L., Massion, J., Grangetto, A.: Relations between ventrolateral nucleus and motor cortex and their possible role in central organization of motor control. Brain Res. 60, 1–20 (1973)
Sakata, H., Ishijima, T., Toyoda, Y.: Single unit studies on ventrolateral nucleus of the thalamus in cat: its relation to the cerebellum, motor cortex and basal ganglia. Jap. J. Physiol. 16, 42–60 (1966)
Sasaki, K., Kawaguchi, S., Matsuda, Y., Mizuno, N.: Electrophysiological studies on cerebellocerebral projections in the cat. Exp. Brain Res. 16, 75–89 (1972a)
Sasaki, K., Matsuda, Y., Kawaguchi, S., Mizuno, N.: On the cerebello-thalamo-cerebral pathway for the parietal cortex. Exp. Brain Res. 16, 89–103 (1972b)
Strick, P.L.: Cortical projections of the feline thalamic nucleus ventralis lateralis. Brain Res. 20, 130–134 (1970a)
Strick, P.L.: Experimental study of thalamo-cortical projections from the nuclei ventralis lateralis (VL) and ventralis anterior (VA). Anat. Rec. 166, 384 (1970b)
Strick, P.L.: Light microscopic analysis of the cortical projection of the thalamic ventrolateral nucleus in the cat. Brain Res. 55, 1–24 (1973)
Tömböl, T.: Short neurons and their synaptic relations in the specific thalamic nuclei. Brain Res. 3, 307–326 (1967)
Uno, M., Yoshida, M.: Monosynaptic inhibition of thalamic neurones produced by stimulation of the pallidal nucleus in cats. Brain Res. 99, 377–380 (1975)
Uno, M., Yoshida, M., Hirota, I.: The mode of cerebello-thalamic relay transmission investigated with intracellular recording from cells of the ventrolateral nucleus of cat's thalamus. Exp. Brain Res. 10, 121–139 (1970)
Voogd, J.: The cerebellum of the cat. Structure and fibre connexions. Thesis. Assen: Van Gorcum and Comp. 1964
Woolsey, C.N.: Organization of somatic sensory and motor areas of the cerebral cortex. In: Biological and biochemical bases of behavior (eds. H.F. Harlow, C.N. Woolsey), pp. 63–81. Madison: University of Wisconsin Press 1958
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Rispal-Padel, L., Grangetto, A. The cerebello-thalamo-cortical pathway. Topographical investigation at the unitary level in the cat. Exp Brain Res 28, 101–123 (1977). https://doi.org/10.1007/BF00237089
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DOI: https://doi.org/10.1007/BF00237089