Summary
It has previously been reported that the primitive primate Tupaia belangeri develops a renal failure when exposed to psychosocial stress. In order to learn if this high susceptibility to stress of the Tupaia kidney can be correlated with morphological and functional parameters of the Juxtaglomerular apparatus (JGA) and the renin-angiotensin system, comparative experiments were performed on Tupaia and rat.
Our results reveal an outstandingly high potency of the JGA and the renin-angiotensin system in Tupaia as evident from the following findings: The Tupaia JGA contains a great number of epithelioid cells abounding in renin granules (electron microscopy). The renin content of the Tupaia kidney is considerably higher than in the rat (radio-immunoassay). The sympathetic innervation of the kidney and especially of the JGA is abundant in Tupaia (fluorescence and electron microscopy). Catecholamine contents of the kidney and other organs are significantly higher in Tupaia than in rats (spectrophotofluorometry).
Our results support the previously developed concept of a potent intrarenal neuroendocrine interaction at the JGA level favouring, under certain conditions of social stress, the development of acute renal failure in Tupaia belangeri.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anton AH, Sayre DF (1962) A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. J Pharmacol Exper Therap Baltimore 138:360–375
Atlas D, Melamed E, Lahav M (1978) Beta-adrenergic receptors in rat kidney. Direct localisation by a fluorescent beta-blocker. Lab Invest 36:No5, 465–468
Axelsson S, Björklund A, Falck B, Lindvall O, Svensson LA (1973) Glyoxylic acid condensation: A new fluorescence method for the histochemical demonstration of biogenic monoamines. Acta Physiol Scand 89:57–62
Barnett SA (1958) Physiological effects of “social stress” in wild rats. 1. The adrenal cortex. J Psychosom Res 3:1–11
Barnett SA, Eaton JC, McCallum HM (1960) Physiological effects of “social stress” in wild rats. 2. Liver glycogen and blood glucose. J Psychosom Res 4:251–260
Battenberg ELF, Bloom FE (1975) A rapid, simple and more sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid induced fluorescence. I. Specificity. Psychopharmacol Commun 1:3–13
Brock J (1964) Die Nieren. VEV Verlag, Berlin
Coote JH, Johns EJ, MacLeod HV, Singer B (1972) Effect of renal nerve stimulation, renal blood flow, and adrenergic blockade on plasma renin activity in the cat. J Physiol (Lond) 226:15–36
Doerr W (1970) Spezielle pathologische Anatomie I. Springer-Verlag, Berlin Heidelberg New York
Eggena P, Chu CL, Barret JD, Sambhi MP (1976) Purification and partial characterisation of human angiotensinogen. Biochim Biophys Acta 427:208–217
Forssmann WG, Taugner T (1977) Studies on the juxtaglomerular apparatus. V. The juxtaglomerular apparatus in Tupaia with special reference to intercellular contacts. Cell Tissue Res 177:291–305
Forssmann WG, Ito S, Weihe E, Aoki A, Dym M, Fawcett DW (1977) An improved perfusion fixation method for the testis. Anat Rec 188:307–314
Ganong WF (1972) Effects of sympathetic activity and ACTH on renin and aldosterone secretion. In: Genest J, Koiw E (eds) Hypertension. Springer-Verlag, New York Heidelberg, pp 2–14
Ganten D, Schelling P, Hoffmann WE, Phillips MJ, Ganten U (1978) The measurement of extrarenal iso-renins. In: Hummerich W, Poulsen K (eds) Radioimmunoassay-Renin-Angiotensin. Thieme Verlag, Stuttgart, pp 144–155
Gorgas K (1978) Struktur und Innervation des juxtaglomerulären Apparates der Ratte. Adv Anat 54:1–84
Green RG, Larson CL, Bell JF (1939) Shock disease as the cause of the periodical decimation of the snowshoe hare. Am J Hyg 30B:83–102
Henry P, Stephens P (1969) The use of psychosocial stimuli to induce renal and cardiovascular pathology in mice. Psychosom Med 31:454–455
Henry P, Meehan JP, Stephens PM (1967) The use of psychosocial stimuli to induce prolonged systolic hypertension in mice. Psychosom Med 29:408–432
Henry P, Ely DL, Stephens PM, Ratcliffe HL, Santisteban GA, Shapiro AP (1971) The role of psychosocial factors in the development of arteriosclerosis in CBA mice: observations on the heart, kidney and aorta. Atherosclerosis 14:203–218
Hoff F (1962) Klinische Physiologie und Pathologie. Thieme Verlag, Stuttgart
Holst D von (1972) Renal failure as the cause of death in Tupaia belangeri exposed to persistent social stress. J Comp Physiol 78:236–273
Johnson JA, Davis JO, Witty RT (1971) Effects of catecholamine and renal nerve stimulation on renin release in the nonfiltering kidney. Circ Res 29:646–653
Karnovsky MJ (1971) Use of ferrocyanide-reduced osmium tetroxide in electron microscopy. J Cell Biol 51:ASCB abstracts, 146
La Grange RG, Sloop CH (1973) Selective stimulation of renal nerves in the anesthetized dog. Effect on renin release during controlled changes in renal hemodynamics. Circ Res 33:704–712
Lindvall O, Björklund A (1974) The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons. Histochemistry 39:97–127
Lindvall O, Björklund A, Hökfelt T, Ljungdhal A (1973) Application of the glyoxylic acid method to Vibratome sections for improved visualization of central catecholamine neurons. Histochemie 35:31–38
Luft JH (1973) Embedding media — old and new. In: Koehler JH (ed) Advanced techniques in biological electron microscopy. Springer-Verlag, New York, pp 1–34
Schnermann J, Ploth DW, Hermle M (1976) Activation of tubulo-glomerular feedback by chloride transport. Pflügers Arch 362:299–240
Studnitz W v (1975) Fluorimetrische Bestimmung von Adrenalin und Noradrenalin im Urin. In: Breuer H, Hamel D, Krüskemper HL (Hrsg) Methoden der Hormonbestimmung. Thieme Verlag, Stuttgart, S 50–54
Taugner R, Schiller A, Kaissling B, Kriz W (1978) Gap junctional coupling between the JGA and the glomerular tuft. Cell Tissue Res 186:279–285
Thurau K, Mason J (1974) The intrarenal function of the juxtaglomerular apparatus. In: Thurau K (ed) MTP-Int. Review of Science, Physiology, Series one, Vol 6. Butterworths, London, pp 357–390
Vander AJ (1965) Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs. Am J Physiol 209:659–662
Zollinger HU (1966) Niere und ableitende Harnwege. Springer-Verlag, Berlin Heidelberg New York
Author information
Authors and Affiliations
Additional information
The studies were supported by the German Research Foundation within the SFB90 “Cardiovasculäres System”
Rights and permissions
About this article
Cite this article
Taugner, R., Forssmann, W.G., Ganten, D. et al. Studies on the juxtaglomerular apparatus VI. Sympathetic innervation, catecholamines and the renin-angiotensin-system in rats and tree-shrews (Tupaia belangeri). Cell Tissue Res. 212, 375–382 (1980). https://doi.org/10.1007/BF00236504
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00236504