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Relation of callosal and striate-extrastriate cortical connections in the rat: Morphological definition of extrastriate visual areas

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Summary

The main purpose of this study was to correlate the tangential distributions of visual callosal and striate-extrastriate connections in the rat. Cells of origin and terminations of the visual callosal pathway of one hemisphere were labeled by the anterograde and retrograde transport of horseradish peroxidase (HRP) after multiple injections of this enzyme in the contralateral hemisphere, while ipsilateral striate-extrastriate projection fields were revealed by using the autoradiographic method following single injections of 3H-proline in striate cortex. A remarkable complementarity in the distribution of both cortico-cortical pathways was revealed by superimposing in a camera lucida the patterns of callosal and striate-extrastriate projections from consecutive tangential sections processed for HRP and autoradiography, respectively. Projections from striate cortex are distributed into multiple extrastriate fields which are partially or totally surrounded by cortical strips containing dense and overlapping accumulations of labeled callosal cells and terminations. In addition to projections to the following striate recipient areas described in previous reports: posterior (P), posterolateral (PL), lateromedial (LM), laterolateral (LL), anterolateral (AL) and anteromedial (AM); projections to laterointermediate (LI), laterolateral anterior (LLa), anterior (A), medial (M) and pararhinal (PR) areas were defined in the present study. Striate-extrastriate projection fields occupy only a portion of the acallosal islands that contain them, and the location of the fields within these islands correlates with the retinotopic location of the isotope injection in striate cortex. When compared to previous physiological and anatomical maps of extrastriate visual areas in the rat, the present results indicate that the distribution of callosal connections correlates with the borders of extrastriate visual areas, and that the projection from striate cortex into these areas is retinotopically organized. Surprisingly, a direct projection from striate cortex to the head representation region in somatosensory cortex was labeled, a finding that challenges the view that primary sensory areas do not connect directly.

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References

  • Berlucchi G, Gazzaniga MS, Rizzolatti G (1967) Microelectrode analysis of transfer of visual information by the corpus callosum. Arch Ital Biol 105: 583–596

    Google Scholar 

  • Cowan WM, Gottlieb DI, Hendrickson JL, Price JL, Woolsey TA (1972) The autoradiographic demonstration of axonal connections in the central nervous system. Brain Res 37: 21–51

    Google Scholar 

  • Cusick CG, Lund RD (1981) The distribution of the callosal projection to the occipital visual cortex in rats and mice. Brain Res 214: 239–259

    Google Scholar 

  • Espinoza SG, Thomas HC (1983) Retinotopic organization of striate and extrastriate visual cortex in the hooded rat. Brain Res 272: 137–144

    Google Scholar 

  • Gilbert CD, Wiesel TN (1980) Interleaving projections in corticocortical connections. Neurosci Abst 6: 315

    Google Scholar 

  • Gilbert CD, Wiesel TN (1981) Projection bands in visual cortex. Neurosci Abst 7: 356

    Google Scholar 

  • Hubel DH, Wiesel TN (1967) Cortical and callosal connections concerned with the vertical meridian of visual fields in the cat. J Neurophysiol 30: 1561–1573

    Google Scholar 

  • Mesulam MM (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26: 106–117

    CAS  PubMed  Google Scholar 

  • Montero VM (1973) Evoked responses in the rat's visual cortex to contralateral, ipsilateral, and restricted photic stimulation. Brain Res 53: 192–196

    Google Scholar 

  • Montero VM (1980) Patterns of connections from the striate cortex to cortical visual areas in superior temporal sulcus of macaque and middle temporal gyrus of owl monkey. J Comp Neurol 189: 45–59

    Google Scholar 

  • Montero VM (1981a) Comparative studies on the visual cortex. In: Woolsey CN (ed) Multiple visual areas. Humana press, Clifton NJ (Cortical Sensory Organization, Vol. 2, pp 33–81)

    Google Scholar 

  • Montero VM (1981b) Topography of the cortico-cortical connections from the striate cortex in the cat. Brain Behav Evol 18: 194–218

    Google Scholar 

  • Montero VM, Bravo H, Fernandez V (1973a) Striate-peristriate cortico-cortical connections in the albino and gray rat. Brain Res 53: 202–207

    Google Scholar 

  • Montero VM, Cliffer KD (1981) Cortical connections from the striate cortex in the gray squirrel: definition of extrastriate cortical visual areas. Neurosci Abst 7: 763

    Google Scholar 

  • Montero VM, Murphy EH (1976) Cortico-cortical connections from the striate cortex in the rabbit. Anat Rec 183: 483

    Google Scholar 

  • Montero VM, Rojas A, Torrealba F (1973b) Retinotopic organization of striate and peristriate visual cortex in the albino rat. Brain Res 53: 197–201

    Google Scholar 

  • Newsome WT, Allman JM (1980) Interhemispheric connections of visual cortex in the owl monkey, Aotus trivirgatus, and the bushbaby, Galago senegalensis. J Comp Neurol 194: 209–233

    Google Scholar 

  • Olavarria J, Mendez B (1979) The representations of the visual field on the posterior cortex of Octodon degus. Brain Res 161: 539–543

    Google Scholar 

  • Olavarria J, Mignano LR, Van Sluyters RC (1982) Pattern of extrastriate visual areas connecting reciprocally with the striate cortex in the mouse. Exp Neurol 78: 775–779

    Google Scholar 

  • Olavarria J, Montero VM (1981) Reciprocal connections between the striate cortex and extrastriate cortical visual areas in the rat. Brain Res 217: 358–363

    Google Scholar 

  • Olavarria J, Montero VM (1982) Morphological definition of extrastriate visual areas in the rat by the distribution of callosal and striate-extrastriate connections. Invest Ophthalmol Visual Sci, ARVO Abst Suppl. 22: 47

    Google Scholar 

  • Olavarria J, Torrealba F (1978) The effect of acute lesions of the striate cortex on the retinotopic organization of the lateral peristriate cortex in the rat. Brain Res 151: 386–391

    Google Scholar 

  • Olavarria J, Van Sluyters RC (1982) The projection from striate and extrastriate cortical areas to the superior colliculus in the rat. Brain Res 242: 332–336

    Google Scholar 

  • Olavarria J, Van Sluyters RC (1983a) Widespread callosal connections in infragranular visual cortex of the rat. Brain Res (in press)

  • Olavarria J, Van Sluyters RC (1983b) The pattern of visual callosal connections in the cat as revealed in tangential sections of the unfolded cortex. Neurosci Abst 9: 155

    Google Scholar 

  • Rojas JA, Montero VM, Rubles L (1964) Organizacion funcionalde la corteza visual de la rata. Proc VI Congr Asoc Latinam Ciencias Fisiol, Vina del Mar, Chile, pp 98

  • Sanides D (1978) The retinotopic distribution of visual callosal projections in the suprasylvian visual areas compared to the classical visual areas (17, 18, 19) in the cat. Exp Brain Res 33: 435–443

    Google Scholar 

  • Segraves MA, Rosenquist AC (1982) The distribution of the cells of origin of callosal projections in cat visual cortex. J Neuroscience 2: 1079–1089

    Google Scholar 

  • Shatz C (1977) Abnormal interhemispheric connections in the visual system of Boston Siamese cats: a physiological study. J Comp Neurol 171: 229–246

    Google Scholar 

  • Siminoff R, Schwassman HO, Kruger L (1966) An electrophysiological study of the visual projection to the superior colliculus of the rat. J Comp Neurol 127: 435–444

    Google Scholar 

  • Simmons PA, Lemmon V, Pearlman AL (1982) Afferent and efferent connections of the striate and extrastriate visual cortex of the normal and reeler mouse. J Comp Neurol 211: 295–308

    Google Scholar 

  • Tusa RJ, Palmer RA, Rosenquist AC (1981) Multiple cortical visual areas: visual field topography in the cat. In: Woolsey CN (ed) Multiple Visual areas. Humana Press, Clifton, NJ (Cortical Sensory Organization, Vol 2, pp 1–31)

    Google Scholar 

  • Van Essen DC (1979) Visual areas of the cerebral cortex. Ann Rev Neurosci 2: 227–263

    Google Scholar 

  • Van Essen DC, Zeki SM (1978) The topographic organization of rhesus monkey prestriate cortex. J Physiol (Lond) 277: 193–226

    Google Scholar 

  • Van Essen DC, Newsome WT, Bixby JL (1982) The pattern of interhemispheric connections and its relationship to extrastriate visual areas in the macaque monkey. J Neuroscience 2: 265–283

    Google Scholar 

  • Wagor E, Mangini NJ, Pearlman AL (1980) Retinotopic organization of striate and extrastriate visual cortex in the mouse. J Comp Neurol 193: 187–202

    Google Scholar 

  • Welker C (1971) Microelectrode delineation of fine somatotopic organization of SmI cerebral cortex in albino rat. Brain Res 26: 259–275

    Google Scholar 

  • Whitteridge D (1965) Area 18 and the vertical meridian of vision. In: Ettlinger EG (ed) CIBA studies group 20, Functions of the corpus callosum. Churchill, London

    Google Scholar 

  • Woolsey CN, Sitthi-Amorn C, Keesey UT, Holub RA (1973) Cortical visual areas of the rabbit. Soc Neurosci Mtg Abst, San Diego, p 180

  • Zaborsky L, Wolff JR (1982) Distribution patterns and individual variations of callosal connections in the albino rat. Anat Embryol 165: 213–232

    Google Scholar 

  • Zeki SM (1977) Simultaneous anatomical demonstration of the representation of the vertical and horizontal meridians in areas V2 and V3 of rhesus monkey visual cortex. Proc R Soc Lond B 195: 517–523

    Google Scholar 

  • Zeki SM (1978) The cortical projections of foveal striate cortex in the rhesus monkey. J Physiol (Lond) 277: 227–244

    Google Scholar 

  • Zeki SM, Sandeman DR (1976) Combined anatomical and electrophysiological studies on the boundary between the second and third visual areas of rhesus monkey cortex. Proc R Soc Lond B 194: 555–662

    Google Scholar 

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Author notes

  1. J. Olavarria

    Present address: Neurobiology Group, School of Optometry, University of California, 94720, Berkeley, CA, USA

Authors and Affiliations

  1. Department of Neurophysiology, Waisman Center, University of Wisconsin, 53705, Madison, WI, USA

    J. Olavarria & V. M. Montero

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  1. J. Olavarria
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  2. V. M. Montero
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Supported by NIH grants EY 02877 to V.M.M. and HD 3352 to the Waisman Center

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Olavarria, J., Montero, V.M. Relation of callosal and striate-extrastriate cortical connections in the rat: Morphological definition of extrastriate visual areas. Exp Brain Res 54, 240–252 (1984). https://doi.org/10.1007/BF00236223

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  • DOI: https://doi.org/10.1007/BF00236223

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