The effects of L-carnitine administration on maximal exercise capacity were studied in a double-blind, cross-over trial on ten moderately trained young men. A quantity of 2 g of L-carnitine or a placebo were administered orally in random order to these subjects 1 h before they began exercise on a cycle ergometer. Exercise intensity was increased by 50-W increments every 3 min until they became exhausted. After 72-h recovery, the same exercise regime was repeated but this time the subjects, who had previously received L-carnitine, were now given the placebo and vice versa. The results showed that at the maximal exercise intensity, treatment with L-carnitine significantly increased both maximal oxygen uptake, and power output. Moreover, at similar exercise intensities in the L-carnitine trial oxygen uptake, carbon dioxide production, pulmonary ventilation and plasma lactate were reduced. It is concluded that under these experimental conditions pretreatment with L-carnitine favoured aerobic processes resulting in a more efficient performance. Possible mechanisms producing this effect are discussed.
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Angelini C, Vergani L, Costa L, Martinuzzi A, Dunner E, Marescotti C, Nosadini R (1986) Use of carnitine in exercise physiology. Adv Clin Enzyme 4:103–110
Bjorkman O (1986) Fuel utilization during exercise. In: Benzi G, Packer L, Siliprandi N (eds) Biochemical aspects of physical exercise. Elsevier, Amsterdam, pp 245–260
Brecher P (1983) The interaction of long-chain acyl-CoA with membranes. Mol Cell Biochem 57:3–15
Bremer J (1983) Carnitine metabolism and functions. Physiol Rev 63:1430–1480
Bünger R, Mallet RT, Hartman DA (1989) Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure. Eur J Biochem 180:221–233
Carlin JJ, Redoan WG, Sanjak M, Hodach R (1986) Carnitine metabolism during prolonged exercise and recovery in humans. J Appl Physiol 55:489–495
Ciman M, Caldesi-Valeri V, Siliprandi N (1978) Carnitine and acetylcarnitine in skeletal and cardiac muscle. Int J Vitam Nutr Res 48:177–181
Di Prampero PE (1986) Central and peripheral factors limiting 489–1O2max in humans. In: Benzi G, Packer L, Siliprandi N (eds) Biochemical aspects of physical exercise. Elsevier, Amsterdam, pp 63–71
Foster CVL, Harris RC (1987) Formation of acetylcarnitine in muscle of horse during high intensity exercise. Eur J Appl Physiol 56:639–642
Gollnick PD (1986) Adaptation in skeletal muscle to endurance training: implication for metabolic control and performance. In: Benzi G, Packer L, Siliprandi N (eds) Biochemical aspects of physical exercise. Elsevier, Amsterdam, pp 159–169
Greig C, Finch KM, Jones DA, Cooper M, Sargeant AJ, Forte CA (1987) The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. Eur J Appl Physiol 56:457–460
Gutmann I, Wahlefeld AW (1974) L-(+)-lactate. Determination with lactate dehydrogenase and NAD. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Verlag Chemie, Weinheim, pp 1464–1468
Harper P, Elwin CE, Cederblad G (1988) Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects. Eur J Clin Pharmacol 35:555–562
Harris RC, Foster CVL, Hultman E (1987) Acetylcarnitine formation during intense muscular contraction in humans. J Appl Physiol 63:440–442
Hiatt WR, Regenstein JG, Wolfel EE, Ruff L, Brass EP (1989) Carnitine and acetylcarnitine metabolism during exercise in humans. J Clin Invest 84:1167–1173
Holloszy JO, Coyle EF (1984) Adaptation of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56:831–838
Lennon DLF, Stratman FW, Shrago E, Nagle FJ, Madden M, Hanson P, Carter AL (1983) Effects of acute moderate intensity exercise on carnitine metabolism in man and woman. J Appl Physiol Respir Environ Exerc Physiol 55:489–495
Marconi C, Sassi G, Carpinelli A, Cerretelli P (1985) Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur J Appl Physiol 54:131–135
Paulson DJ, Shug AL (1984) Inhibition of the adenine nucleotide translocator by matrix-localized palmitoyl-CoA in heart mitochondria. Biochim Biophys Acta 766:70–76
Siliprandi N, Sartorelli L, Ciman M, Di Lisa F (1989) Carnitine: metabolism and clinical chemistry. Clin Chim Acta 183:3–12
Siliprandi N, Di Lisa F, Pieralisi G, Ripari P, Maccari F, Menabó R, Giamberardino MA, Vecchiet L (1990) Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. Biochim Biophys Acta 1034:17–21
Soop M, Björkman O, Cederblad G, Hagenfeldt L, Wahren J (1988) Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J Appl Physiol 64:2394–2399
Uziel G, Garavaglia B, Di Donato S (1988) Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in mitochondria isolated from human skeletal muscle. Muscle Nerve 11:722–724
Zweier JL, Jacobus WE (1987) Substrate-induced alterations of high-energy phosphate metabolism and contractile function in the perfused heart. J Biol Chem 263:8015–8021
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Vecchiet, L., Di Lisa, F., Pieralisi, G. et al. Influence of L-carnitine administration on maximal physical exercise. Europ. J. Appl. Physiol. 61, 486–490 (1990). https://doi.org/10.1007/BF00236072
- Maximal exercise