Influence of L-carnitine administration on maximal physical exercise

Summary

The effects of L-carnitine administration on maximal exercise capacity were studied in a double-blind, cross-over trial on ten moderately trained young men. A quantity of 2 g of L-carnitine or a placebo were administered orally in random order to these subjects 1 h before they began exercise on a cycle ergometer. Exercise intensity was increased by 50-W increments every 3 min until they became exhausted. After 72-h recovery, the same exercise regime was repeated but this time the subjects, who had previously received L-carnitine, were now given the placebo and vice versa. The results showed that at the maximal exercise intensity, treatment with L-carnitine significantly increased both maximal oxygen uptake, and power output. Moreover, at similar exercise intensities in the L-carnitine trial oxygen uptake, carbon dioxide production, pulmonary ventilation and plasma lactate were reduced. It is concluded that under these experimental conditions pretreatment with L-carnitine favoured aerobic processes resulting in a more efficient performance. Possible mechanisms producing this effect are discussed.

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Correspondence to N. Siliprandi.

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Vecchiet, L., Di Lisa, F., Pieralisi, G. et al. Influence of L-carnitine administration on maximal physical exercise. Europ. J. Appl. Physiol. 61, 486–490 (1990). https://doi.org/10.1007/BF00236072

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Key words

  • Maximal exercise
  • L-carnitine
  • Lactate